Topics:
Breast Cancer • Radiation Oncology • Medical Oncology • Her2+ • Stage IV • Cardiotoxicity • Cardiology
What is the rate of a cardiac events that you quote to a patient with preexisting heart disease going on trastuzumab for metastatic Her2+ breast cancer?
How does it vary for patients with a history of hypertension, diabetes, CHF, and coronary artery disease?
Answer from: Medical Oncologist at Community Practice
I tell patients that it depends on their baseline risk factors and that some have reported rates as high as 25-28%. I discuss that if they have had prior anthracycline therapy, borderline baseline LVEF (50-54%), age > 65, and other cardiac risk factors like hypertension, that they could fall into...
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