Would you consider hormone replacement therapy in young women with germline BRCA1 mutation and history of triple negative breast cancer who underwent bilateral mastectomy and prophylactic bilateral salpingo-oophorectomy?

Topics: Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Triple negative • Ohio State University • NCI-CCC Breast Tumor Board Question • BRCA+ • Breast Cancer, Non-metastatic

This situation can feel uncomfortable. Would this feel safer if patient is s/p mastectomy and had TNBC?

Answer from: Medical Oncologist at Academic Institution

There is inadequate data to clearly answer the question of safety of HRT after a diagnosis of breast cancer. A recent review by Ugras and Rahman summarized the published literature and concluded that the evidence does not suggest an increase in recurrence or death with the use of HRT in this setting...

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Medical Oncologist
Finkelstein et al., PMID: 18160467. “The mo...

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