Topics:
Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Triple negative • University of Iowa • NCI-CCC Breast Tumor Board Question • Breast Cancer, Metastatic
Would you consider surgical management of a TNBC primary after a patient has had radiographic resolution of oligometastatic disease?
Patient with T2N1 disease and isolated liver metastases. Axilla and liver completely responded to chemo + IO, but limited residual breast enhancement on PET/CT.
Answer from: Medical Oncologist at Community Practice
Randomized studies have revealed no advantage with removal of primary; however, there is a growing body of evidence in other cancers for treating oligo-metastatic disease with curative intent. Breast cancer is not colon cancer, etc but I feel the concept is novel and in the era of highly effective s...
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Answer from: Medical Oncologist at Community Practice
A challenging case. The two major randomized clinical trials have shown no benefit of surgery in de novo metastatic disease. However, I still think that a fraction of patients may benefit from prolonged control of disease (disease-free). It is also true that there are patients with oligo liver...