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Would you consider surgical management of a TNBC primary after a patient has had radiographic resolution of oligometastatic disease?

Patient with T2N1 disease and isolated liver metastases. Axilla and liver completely responded to chemo + IO, but limited residual breast enhancement on PET/CT.
2 Answers
Mednet Member
Mednet Member
Medical Oncology · Northwestern Medicine Cancer Center at KishHealth
Answered on

Randomized studies have revealed no advantage with removal of primary; however, there is a growing body of evidence in other cancers for treating oligo-metastatic disease with curative intent. Breast cancer is not colon cancer, etc but I feel the concept is novel and in the era of highly effective s...

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Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Hawai'i Cancer Center
Answered on

A challenging case. The two major randomized clinical trials have shown no benefit of surgery in de novo metastatic disease. However, I still think that a fraction of patients may benefit from prolonged control of disease (disease-free). It is also true that there are patients with oligo liver met ...

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