NCI-CCC Tumor Board Question   

I am not sure there is much efficacy for a regimen that does not include asparaginase. The patient received 2 cycles of P-GemOx, then was admitted for...

At the time of initial diagnosis, there was no clear CNS involvement. When it became clinically apparent disease was refractory to EPOCH, there was CS...

Would you continue R-CHOP or would you switch therapy? 

Would you consider this de novo DLBCL (unable to assess for clonality)? How would you handle prior anthracycline exposure? 

Is the therapeutic purpose of the proteasome inhibitor to maximize total dosage per week or number of infusions per week?

Which PI and at what dosing intervals? Dexamethasone or not? Emory has now published data with VRd consolidation as well as KPd consolidation, while ...

240-300 mg/m2 prior exposure. How would your management change in young fit/older individuals with comorbidities? Would you obtain interval TTE during...

Do you incorporate PEG-asparaginase or brentuximab vedotin (for CD30-expressing malignant cells) into anthracycline-based induction regimens? Do you c...

How do you choose between CAR-T and autoSCT, for example? 

Would you still go to auto or consider allo? 

Would you intercalate HD-MTX with her CHOEP?

For pts w/ eGFR between 30-60

CAR-T (any specific preference of product?) vs bispecific antibodies vs any other specific agents not previously utilized?

Is a repeatedly abnormal serum immunofixation all it takes for MGUS?

Would you continue with daratumumab maintenance per ANDROMEDA or switch regimen?

Ki67  = 90% with multiple small nodes on PET scan and normal CBC

Patient in mid-30s with no major medical history presented with isolated left neck swelling. Incisional biopsy w/ HTLV1/2 associated ATLL, Ki67 of >...