Moffitt Cancer Center   

Do you have a specific age cutoff?

Would a pCR to neoadjuvant chemotherapy change your management? (ER <5%, PR <5%)

Would you send an Oncotype RS to determine the role of adjuvant chemotherapy and/or endocrine therapy?

Does lymph node positivity change your management?

Would your answer change if the new lesion is ALH/ADH?

Patient completed adjuvant AC-T 8 months prior to recurrence. BRCA negative, foundation medicine NGS pending. 

PD-L1 is low and she has residual neuropathy from neoadjuvant paclitaxel.

If yes, would you offer tamoxifen or ovarian suppression plus AI?

This patient is interested in conceiving and therefore would like to wait to start the tamoxifen.

If finished adjuvantly, what would you do -- continue TC or change chemotherapy? 

For early stage disease in a single breast, would you consider neoadjuvant chemotherapy or upfront surgical staging followed by adjuvant therapy? What...

RP node with treatment related changes and surgical specimen from TAH/BSO no other foci of malignancy found. 

Does hormone receptor status impact your decision?

greatest measuring 1.0cm.

Patient did not receive neoadjuvant therapy.

(For instance, TCx4 instead of ddAC->T for smaller tumors?)Does this affect your decision about treating with neoadjuvant versus adjuvant chemother...