Medical Oncology

Thrombosis   

Questions discussed in this category


Or do you generally prefer warfarin/non-DOAC agents? Do you consider trialing DOACs and testing anti-Xa DOAC levels to assess for absorption?

If they have been on IV heparin for 3 days, for example, would you subtract those days from the recommended loading dose time?

Do you do additional workup for venous obstruction or any other different testing/evaluation?

Estimating blood loss from hemoptysis is not always reliable. The bleeding may be due to the PE itself. Is anticoagulation with any degree of hemoptys...

While follow up ultrasound is not usually recommended in provoked DVT, it often is done either for other reasons or by other physicians. Would this in...

What is the work up and what is the duration of anticoagulation if used?

Specifically, asymptomatic subsegmental PE diagnosed within a month from planned bilateral mastectomy for breast cancer. 

Would you consider low dose indefinite anticoagulation in any scenario? Any difference in approach between hematological malignancy and solid tum...

- Dialysis catheter used for hemodialysis- RIJ thrombus in dialysis catheter was incidentally found- Patient asymptomatic with no prior history of VTE...

How does cirrhosis and/or underlying thrombophilia affect your decision?

For example, for outpatients or resource-limited settings with a moderate probability 4-T score (but low clinical suspicion), would you ever consider ...

Would you offer indefinite anticoagulation if the event is unprovoked and the patient has low bleeding risk? 

Provoked or unprovoked VTE: Do you use D-Dimer (or even repeat imaging to reassess residual clot) in any capacity to guide anticoagulation duration? E...

While there are many factors involving:- type (DVT vs PE, unprovoked vs provoked) and severity of venous thromboembolism (VTE) size- duration of antic...

Is there any difference between anticoagulants in this clinical context (e.g. anti-Xa inhibitors vs warfarin vs LMWH)?

Does having a concurrent consumptive process e.g. DIC change your management? 

While thrombophilia testing is not routinely recommended prior to starting OCPs, how about after the development of a VTE?

Ref: EINSTEIN-CHOICE and AMPLIFY-EXT Would you approach this differently in patients with inherited thrombophilias?

Is there a preferred strategy of transfusional support versus reduced-dose anticoagulation during the duration of thrombocytopenia?

Would it make a difference if the VTE diagnosis occurs during bevacizumab therapy or whether it preceded the cancer diagnosis?


Papers discussed in this category


Blood Transfus, 2018 Oct 24

J Thromb Haemost, 2018 May 08

J Vasc Interv Radiol, 2020 Sep 09

Blood, 2013-12-05

Blood Adv,

Blood,

Thrombosis, 2013

Thrombosis journal, 2023 Oct 26

PLoS One, 2021 Apr 08

N Engl J Med, 2021 Apr 14

J Natl Cancer Inst, 2011 Jul 09

Br J Clin Pharmacol, 2020 Jun 02

J Thromb Thrombolysis,

Blood advances, 2018-11-27

Blood advances, 2018-11-27

Blood Adv, 2017 Jun 22

Haematologica, 2019 Jan 03

Respirology (Carlton, Vic.), 2018 Jul 16

Platelets, 2023 Oct 11

Blood, 2011 Aug 11