Pediatric Oncology

Infectious Disease

Questions discussed in this category

What approaches can we take to initiate therapy and improve survival rates in patients with HLH?

1 Answer available

What antibiotic, antifungal and antiviral prophylaxis you give post CAR-T therapy, and what is the duration?

1 Answer available

What is your approach to working up diarrhea in an immunocompromised patient?

1 Answer available

For AML patients, when do you stop antiinfective agents?

At the time of count recovery or do you continue it throughout induction and consolidation?

1 Answer available

Would you anticoagulate a patient with splenic infarctions in the setting of CMV viremia?

If so, for how long?

1 Answer available

What is the risk of serious bacterial infection in a febrile solid tumor patient who has not yet started cancer-directed therapy and has normal cell counts with no central line?

1 Answer available

What is your approach to BK hemorrhagic cystitis not responding to cidofovir?

1 Answer available

Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

3 Answers available

Do you hold IV iron in the setting of active infection?

1 Answer available

Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

1 Answer available

In which patients with oncologic or hematologic disorders are you recommending a 3rd dose of mRNA COVID vaccine?

2 Answers available

How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?

Is there a role for empiric antibiotics if there is history of opportunistic infection?

1 Answer available

During induction therapy for acute leukemia, when do you decide to discontinue the antimicrobial prophylaxis?

Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2007-01-25

Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.

Seminars in hematology, 2013-07

Evaluation and management of patients with isolated neutropenia.

Ann Oncol, 2021 Mar 18

Association of Clinical Factors and Recent Anti-Cancer Therapy with COVID-19 Severity among Patients with Cancer: A Report from the COVID-19 and Cancer Consortium.

Clin Microbiol Infect, 2018 Feb 07

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).

Urology, 1982-09

Prevention of cyclophosphamide-induced hemorrhagic cystitis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009-03

Intravesicular cidofovir for the management of BK virus-associated cystitis.

Clin Infect Dis, 2005 Jan 21

Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation.

Pediatr Transplant, 2014 Sep 08

Successful treatment of hemorrhagic cystitis after hematopoietic stem cell transplantation with intravesical hyaluronic acid.

J Clin Oncol, 2021 Apr 30

Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation.

Pediatr Infect Dis J, 2014 Nov

Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study.

Bone Marrow Transplant, 2006 Mar

Estrogen as treatment of hemorrhagic cystitis in children and adolescents undergoing bone marrow transplantation.

Journal of medical case reports, 2014 Mar 04

Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature.

Journal of oncology practice, 2018-09-04

Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update Summary.

Leukemia & lymphoma, 2022 Mar 15

Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax.

Hematology. American Society of Hematology. Education Program, 2020 Dec 04

Updates in infection risk and management in acute leukemia.

Pediatric Oncology

Infectious Disease

Questions discussed in this category

Papers discussed in this category

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