Pediatric Hematology/Oncology

Infectious Disease

Questions discussed in this category

Which biomarkers or diagnostic tools do you prioritize to support the decision to start antifungal treatment in septic patients with no clear source of infection but at high risk for fungal infections?

2 Answers available

Would you use the pneumococcal conjugate-21 vaccine (Capvaxive) instead of the conjugate-20 (Prevnar-20) for routine vaccinations in immunosuppressed patients?

2 Answers available

What is the utility of granulocyte infusions in patients with neutropenia and severe infection?

1 Answer available

When would you initiate exchange transfusion in babesiosis and significant hemolysis?

Is parasitemia >10% and severe hemolysis with Hb less than 7 enough to initiate this?

1 Answer available

What infections should we rule out in patients who develop diarrhea on immunotherapy?

Chemotherapy is associated with acquiring C diff colitis. Does immunotherapy share that same risk and necessitate ruling out infection prior to anti-d...

1 Answer available

Under what circumstances do you consider valacyclovir for the management of VZV disease of the CNS?

2 Answers available

Is there a role for nitazoxanide for treatment of norovirus gastroenteritis in immunocompromised patients?

1 Answer available

Do you recommend lifelong antibiotic prophylaxis, or do you prefer a more selective approach based on risk factors in asplenic patients without a history of severe infections?

2 Answers available

Have you used oral vancomycin as prophylaxis for C difficile infection in patients admitted for allogeneic hematopoietic cell transplant?

2 Answers available

What antibiotic, antifungal and antiviral prophylaxis you give post CAR-T therapy, and what is the duration?

1 Answer available

What is your approach to working up diarrhea in an immunocompromised patient?

1 Answer available

For AML patients, when do you stop antiinfective agents?

At the time of count recovery or do you continue it throughout induction and consolidation?

1 Answer available

Would you anticoagulate a patient with splenic infarctions in the setting of CMV viremia?

If so, for how long?

1 Answer available

What is the risk of serious bacterial infection in a febrile solid tumor patient who has not yet started cancer-directed therapy and has normal cell counts with no central line?

1 Answer available

What is your approach to BK hemorrhagic cystitis not responding to cidofovir?

1 Answer available

Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

3 Answers available

Do you hold IV iron in the setting of active infection?

1 Answer available

Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

1 Answer available

In which patients with oncologic or hematologic disorders are you recommending a 3rd dose of mRNA COVID vaccine?

2 Answers available

How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?

Is there a role for empiric antibiotics if there is history of opportunistic infection?

1 Answer available

During induction therapy for acute leukemia, when do you decide to discontinue the antimicrobial prophylaxis?

Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2007-01-25

Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.

Blood, 2015-10-29

Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection.

Seminars in hematology, 2013-07

Evaluation and management of patients with isolated neutropenia.

Ann Oncol, 2021 Mar 18

Association of Clinical Factors and Recent Anti-Cancer Therapy with COVID-19 Severity among Patients with Cancer: A Report from the COVID-19 and Cancer Consortium.

Clin Microbiol Infect, 2018 Feb 07

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).

Urology, 1982-09

Prevention of cyclophosphamide-induced hemorrhagic cystitis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009-03

Intravesicular cidofovir for the management of BK virus-associated cystitis.

Clin Infect Dis, 2005 Jan 21

Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation.

Pediatr Transplant, 2014 Sep 08

Successful treatment of hemorrhagic cystitis after hematopoietic stem cell transplantation with intravesical hyaluronic acid.

J Clin Oncol, 2021 Apr 30

Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation.

Pediatr Infect Dis J, 2014 Nov

Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study.

Bone Marrow Transplant, 2006 Mar

Estrogen as treatment of hemorrhagic cystitis in children and adolescents undergoing bone marrow transplantation.

Journal of medical case reports, 2014 Mar 04

Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature.

Journal of oncology practice, 2018-09-04

Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update Summary.

Leukemia & lymphoma, 2022 Mar 15

Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax.

Hematology. American Society of Hematology. Education Program, 2020 Dec 04

Updates in infection risk and management in acute leukemia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019-05-30

Oral Vancomycin Prophylaxis Is Highly Effective in Preventing Clostridium difficile Infection in Allogeneic Hematopoietic Cell Transplant Recipients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Aug 22

Effectiveness of Oral Vancomycin for Prevention of Healthcare Facility-Onset Clostridioides difficile Infection in Targeted Patients During Systemic Antibiotic Exposure.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Oct 23

Oral Vancomycin Prophylaxis for Clostridioides difficile in High-Risk Patients Receiving Systemic Antibiotics: What Exactly Are We Preventing?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Aug 22

Perils, Pitfalls, and Promise of Primary Prophylaxis for Clostridioides difficile Infection.

BMJ open, 2023 Sep 13

Evaluation of the effectiveness and safety of oral vancomycin versus placebo in the prevention of recurrence of infection in patients under systemic antibiotic therapy: a phase III, randomised, double-blind clinical trial.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019 Jun 27

Oral Vancomycin Prophylaxis as Secondary Prevention Against Clostridioides difficile Infection in the Hematopoietic Stem Cell Transplantation and Hematologic Malignancy Population.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018-05-17

Detecting Infections Rapidly and Easily for Candidemia Trial, Part 2 (DIRECT2): A Prospective, Multicenter Study of the T2Candida Panel.

The Journal of infection, 2011-11

Norovirus gastroenteritis successfully treated with nitazoxanide.

Alimentary pharmacology & therapeutics, 2006 Nov 15

Nitazoxanide in the treatment of viral gastroenteritis: a randomized double-blind placebo-controlled clinical trial.

Journal of tropical medicine, 2017 Feb 26

Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country.

Lupus, 2014 Jul 30

Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections.

MMWR. Morbidity and mortality weekly report, 2024 Sep 12

Use of 21-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024.

American journal of clinical oncology, 2021 Aug 01

Outcomes of Immune Checkpoint Inhibitor-related Diarrhea or Colitis in Cancer Patients With Superimposed Gastrointestinal Infections.

Annals of gastroenterology, 2022 Jun 02

infection in cancer patients receiving immune checkpoint inhibitors.

Melanoma research, 2023 Mar 27

Clostridium difficile infection and immune checkpoint inhibitor-induced colitis in melanoma: 18 cases and a review of the literature.

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