Radiation Oncology

Immunotherapy   

Questions discussed in this category


I am considering every 6 week pembrolizumab dosing in patients >70 years old in whom I want to reduce clinic visits for, especially in the context ...

How do you prescribe a steroid taper? If it is grade 2, would you keep them on low dose prednisone while continuing? When do you feel comfortable re-c...

Do the results of the unplanned subset analysis of the PACIFIC trial showing no OS benefit in this population lean you away from consolidation?

In patients who have a mixed response or progression and are poor candidates for other systemic agents, would you consider consolidating the chest? Wo...

One example of this scenario would be a patient receiving consolidative durvalumab after chemoRT for stage III NSCLC who develops a new peripheral lun...

Rate of pneumonitis was low in the PACIFIC trial but does it mirror the real world setting? We are seeing increased pneumonitis in our practice.

I recently saw a patient who had been treated with concurrent pembrolizumab-RT elsewhere. Is this an acceptable practice outside the setting of a clin...

These patients have been largely excluded from these trials.  What if the infection is well controlled?

If not what radiation fractionation regimen is preferred for otherwise good KPS patient? 

Is there any consensus regarding the optimal RT dose, fractionation, and timing to the best abscopal response? What is the optimal metastatic site to ...


Papers discussed in this category


Radiat Oncol, 2015 Apr 26

N Engl J Med, 2017 Nov 16

The Lancet. Oncology, 2017-07

International journal of radiation oncology, biology, physics, 2017-06-01

JAMA oncology, 2018-01-11

The New England journal of medicine, 2018-12-13

Future Oncol, 2019 Apr 25

Radiation oncology (London, England), 2014-09-19

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-01

International journal of radiation oncology, biology, physics, 2018-08-01

Int. J. Radiat. Oncol. Biol. Phys., 2016 Jul 15

Eur. Respir. J., 2018 Jan 04

Practical radiation oncology, 2018

The Lancet. Oncology, 2016-07

J Thorac Oncol, 2019 Feb 16

Int. J. Radiat. Oncol. Biol. Phys., 2019 Aug 31

Lung Cancer, 2019 Jan 15

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01

The New England journal of medicine, 2018-08-23

JAMA oncology, 2017-06-01

Neuro-oncology, 2019-02-23