Do you offer consolidative thoracic radiation for oligometastatic NSCLC following upfront immunotherapy?
In patients who have a mixed response or progression and are poor candidates for other systemic agents, would you consider consolidating the chest? Would you be concerned about a higher pneumonitis risk?
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Do you irradiate tumors in the lung during concurrent immunotherapy?
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2 Answers
Mednet Member
Radiation Oncology · Karmanos Cancer Institute - McLaren Proton Therapy Center
Answered on
Yes, I do offer consolidation in patients with oligometastatic lung cancer after immunotherapy. Like @Dr. First Last, often these patients are referred to me at "oligoprogression," when one lesion progresses (often the primary or largest site), but most minor lesions appear to be under control. The ...
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Mednet Member
Radiation Oncology · Yale School of Medicine
Answered on · Updated on
Its important to point out that these patients can be enrolled on the NRG LU-002, which has recently been amended to include metastatic NSCLC patients who get immunotherapy as first-line therapy and have limited sites of disease afterwards. The trial randomizes to consolidative RT or not, and I thin...
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