Rheumatology

Neuro-immunology   

Questions discussed in this category



Do you generally recommend anti-diarrheals, dietary modifications, or consider this an unacceptable side effect and move to other therapies? 

If not, are there any serum or CSF tests you consider to be helpful?

Is a biopsy or EMG helpful in confirming the etiology? What is the best treatment for sarcoid neuropathy?

Is there utility when classic inflammatory markers (ESR,CRP) or disease specific markers (C3, C4, dsDNA) do not correlate with patients disease activi...

Specifically, do you check for any of these: ACE, Vitamin D 1,25, serum lysozyme, soluble IL2 or Adenosine deaminase levels?

For example, the patient may have other findings such as an elevated CRP. Would you diagnose SLE, or would you want to see other serologies or finding...

Do you treat with only an IV steroid pulse or do you use an oral steroid taper as well? How long of a taper do you typically use?

In addition, what formula do you use to calculate the IgG index?

Are there any instances where you would prefer a biosimilar rather than the reference product? 

When it seems fairly certain that this is a drug effect is it something that can just be monitored or requires a change in approach?

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

Small study in pediatric PACNS have evaluated this as a potential marker (Cellucci et al., PMID 22740622)


Papers discussed in this category


Front Neurol, 2019 Jun 06

N Engl J Med,

Lancet, 2016 Mar 04

Arthritis Rheum,

Journal of neurovirology, 2018-06

Muscle & nerve, 2007-01

Annals of neurology, 1990-03

Rheum Dis Clin North Am, 2017 Aug 23

Neurology,

Medicine (Baltimore),

Muscle Nerve, 2014 Dec 23

Clin Microbiol Infect, 2018 Feb 07

Arthritis & rheumatology (Hoboken, N.J.), 2018-03

Clinical pharmacokinetics, 2018-12

Frontiers in immunology, 2018

Clinical immunology (Orlando, Fla.), 2020 Jul 15

The Pediatric infectious disease journal, 2018 Oct

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017 Nov 03

Neurology, 2017-11-14

Neurol Neuroimmunol Neuroinflamm, 2020 Jul 27

Arthritis and rheumatism, 2009-11

Rheumatology (Oxford), 2014 Oct 21

Cureus, 2019 Aug 19

J Rheumatol, 2007 Sep 15

Rheumatol Int, 2007 Jul 20

Lupus, 2017 Feb 26

JAMA neurology, 2018-12-01

Journal of neuroimmunology, 2022 Apr 09

Neurology(R) neuroimmunology & neuroinflammation, 2021 Oct 04

Lung, 2015 Nov 13

Biomolecules, 2022 Sep 30

The New England journal of medicine, 2003-10-16

Immunol Invest, 1985 Jun

Lupus, 2024 Jan 16

Rheumatology (Oxford, England), 2021 Nov 03

Expert review of respiratory medicine, 2023 Jun 23

Therapeutic drug monitoring, 2022 Jun 01

Medicine, 2021 Jan 08

Curr Rheumatol Rep, 2023 Aug

NeoReviews, 2021 Jan

Journal of clinical pharmacology, 2023 Jun