Duke   

Will you use it rather than a carboplatin-containing regimen?

If ADT +/- ARPI + RT, what duration of systemic therapy do you recommend?

What imaging modality do you use (conventional, PSMA PET, etc.)? When do you image (ex: a PSA threshold or PSADT)?

When do you order PSMA PET? Do you preferably order Locametz (gallium Ga 68 gozetotide) PET? 

Would you use it for initial staging or at time of biochemical recurrence?

Do you observe, offer adjuvant pembrolizumab, or give a first-line metastatic regimen (IO/IO or IO/TKI)? Does your recommendation vary based on risk c...

GS 4+4. PSA low (1-2). CT and bone scan negative for lymphadenopathy or metastatic disease.  Prostate MRI pending. 

Does patient age effect your approach? Would you consider RPLND for any patients in light of the phase II SEMS trial presented at the 2021 ASCO GU Ca...

What line would you give pembrolizumab?

What neoadjuvant or adjuvant therapy would you give?

Ex: TKI alone, TKI + checkpoint inhibitor, checkpoint inhibitor alone, TKI + mTOR inhibitor. Please specify drug regimen, if applicable.