Infectious Disease

Transplant Infectious Disease

Questions discussed in this category

How do you approach using fecal microbiota therapy for recurrent Clostridioides difficile infection in immunocompromised patients?

Berry et al., PMID 40759389

1 Answer available

For how long would you treat a patient with latent TB before allowing them to proceed with a liver transplant?

1 Answer available

Is the combination of a negative BAL PJP PCR and normal fungitell enough to rule out PJP pneumonia in an at-risk non-HIV patient?

1 Answer available

What factors influence your decision to initiate antifungal treatment in asymptomatic lung transplant recipients colonized with Aspergillus?

1 Answer available

Would you recommend treating asymptomatic bacteriuria in a kidney transplant patient who has a ureteral stent in place?

1 Answer available

How long do you treat uncomplicated gram-negative rod bacteremia in solid organ transplant recipients?

1 Answer available

Would you consider antifungal prophylaxis for immunocompromised patients with COVID-19 requiring mechanical ventilation, considering the high risk of invasive pulmonary aspergillosis in patients with severe COVID-19?

Feys et al., PMID 37691392

1 Answer available

What is your preferred agent for fungal prophylaxis in a patient post lung transplant with abnormal LFTs?

Do you consider isavuconazole to be less hepatotoxic than other azoles?

2 Answers available

Are there instances when you use letermovir without the addition of acyclovir when managing a kidney transplant recipient for CMV prophylaxis?

3 Answers available

Do you manage antibacterials for enterococcal bacteremia differently in patients with severe immunosuppression?

2 Answers available

Would you recommend imaging of the brain and lungs to investigate potential disseminated disease in a recent heart transplant patient with a skin nodule that grew Rhizopus?

1 Answer available

How would you manage persistent Norovirus diarrheal infections in a kidney transplant patient that are not responding to a decrease in the patient’s maintenance immunosuppressive regimen?

3 Answers available

Do you treat non-albicans strains of Candida on sputum culture or BAL in patients who are immunosuppressed?

2 Answers available

What is your preferred dosing of IV ganciclovir for CMV disease in immunocompromised patients?

1 Answer available

What are your top takeaways from ID Week 2024?

1 Answer available

Would you transition from IV to oral antibiotics in a solid organ transplant recipient with uncomplicated gram-negative bacteremia?

Nussbaum et al., PMID 38195100

1 Answer available

Is there a role for nitazoxanide for treatment of norovirus gastroenteritis in immunocompromised patients?

1 Answer available

Under which circumstances is there a role for reduction in immunosuppression post-SOT in a patient with recurrent CMV viremia and/or disease?

1 Answer available

What is your approach to antimicrobial prophylaxis in adult patients undergoing treatment for HLH?

1 Answer available

Is there a role for secondary CMV prophylaxis in solid organ transplant patients?

1 Answer available

What is current best practice with regards to antibacterial prophylaxis in patients with hematologic malignancy and resolved neutropenic fever (>72 hours)?

1 Answer available

What is your approach to vaccinations and titers for patients with myeloma, who are immunosuppressed and do not have appropriate antibody responses to vaccines?

E.g., for a patient with myeloma, s/p induction therapy, and high-dose chemotherapy, followed by autologous rescue with inappropriate antibody respons...

3 Answers available

Is there ever a role for the use of CMV immune globulin for treatment of CMV viremia and/or disease?

1 Answer available

Do you use letermovir as CMV prophylaxis in solid organ transplant patients?

1 Answer available

Papers discussed in this category

Curr Opin Infect Dis, 2023 Aug 1

Neutropenia and antibiotics: when, what, how and why?

JAMA, 2023 Jul 03

Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017-11-29

Role of Secondary Prophylaxis With Valganciclovir in the Prevention of Recurrent Cytomegalovirus Disease in Solid Organ Transplant Recipients.

Annual review of medicine, 2022 Nov 04

Cytomegalovirus Therapy: Role of Letermovir in Prophylaxis and Treatment in Transplant Recipients.

The Journal of infection, 2011-11

Norovirus gastroenteritis successfully treated with nitazoxanide.

Alimentary pharmacology & therapeutics, 2006 Nov 15

Nitazoxanide in the treatment of viral gastroenteritis: a randomized double-blind placebo-controlled clinical trial.

Journal of tropical medicine, 2017 Feb 26

Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024 Jul 19

Oral Antibiotics for Treatment of Gram-Negative Bacteremia in Solid Organ Transplant Recipients: A Propensity Score Weighted Retrospective Observational Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Nov 05

Orally Administered Human Immunoglobulin Therapy for Norovirus Enteritis in Solid Organ Transplant Recipients: A Case Series at a Single Academic Transplant Center.

Clinical transplantation, 2022 Jan 20

Nitazoxanide treatment for norovirus infection in solid organ transplant recipients.

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