How would you approach systemic therapy for a young post-menopausal woman with locoregional TNBC chest wall recurrence treated with definitive radiation?

Topics: Breast Cancer • Medical Oncology • MD Anderson • NCI-CCC Tumor Board Question • Triple negative • NCI-CCC Breast Tumor Board Question • Breast Cancer, Non-metastatic • tnbc

Patient previously received neoadjuvant ddAC-T with residual disease at surgery, followed by adjuvant capecitabine which was completed 2 months prior to chest wall recurrence.

Answer from: Medical Oncologist at Academic Institution

This is a tough situation with biologically resistant disease with poor prognosis. I would discuss the following steps: 1) Rule out distant disease with staging scans. 2) Confirm receptor status with LRR to r/o disease heterogeneity.3) If LRR TNBC, I would consider adjuvant chemotherapy fo...

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