Topics:
Radiation Oncology • Genitourinary Cancers • Medical Oncology • Urethral Cancer • NCI-CCC Tumor Board Question • UCSF • NCI-CCC GU Tumor Board Question
When would you recommend adjuvant therapy for a patient with urethral adenocarcinoma after partial urethrectomy?
What clinicopathological features would need to be present for you to recommend adjuvant chemotherapy? Would you treat pT3 disease? Any specific histological features?
What adjuvant therapy would you recommend - chemotherapy, radiation or a combination?
Answer from: Medical Oncologist at Community Practice
My first approach in this setting is to have the pathology reviewed by an expert tumor pathologist, and to be sure of the T stage, margins, N/M stage, and whether any tumor markers are heavily expressed. If there is a strongly expressed tumor marker, such as CEA, I will obtain baseline, and interval...
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Answer from: Medical Oncologist at Academic Institution
Treatment of urethral carcinoma varies depending on the gender of the patient, location, and histologic type. Because of rarity, there is a scarcity of data to guide treatment for patients with adenocarcinoma of urethra. Surgery alone is not adequate in most patients with locally advanced urethral c...