Questions discussed in this category
Are you concerned about cases where radiation has to be started urgently before leukapheresis?
In a patient who relapsed following 2nd line transplant, how do you select CAR-T vs bispecifics vs non-T-cell-mediated therapies as outlined in NCCN? ...
Do you speak to different expectations re: ability to achieve PR/CR and/or how this will impact ability to get to later therapies for a patient with p...
Would you prefer CAR-T or bi-specific or neither? If CAR-T, how do you approach lymphodepletion?
How is this entity distinct from other secondary HLH entities?
How do you choose between CAR-T and autoSCT, for example?
Does this differ for a patient who had a longer remission before relapse?
Given the results of ZUMA-7, TRANSFORM, and BELINDA - how does this inform your current practice? What are the currently approved indications for CAR-...
CAR-T (any specific preference of product?) vs bispecific antibodies vs any other specific agents not previously utilized?
Do you limit it to post-pubertal patients? Do you offer it only if they will proceed with bone marrow transplantation after CAR-T?
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Papers discussed in this category
N Engl J Med, 2021 Dec 11
Lancet,
Blood, 2020 Sep 23
International journal of radiation oncology, biology, physics, 2019-12-01
The Lancet. Oncology, 2019-01
Molecular therapy : the journal of the American Society of Gene Therapy, 2018-11-07
Cancer immunology research, 2019-07
Br J Haematol, 2020 Mar 5
Lancet, 2020 Sep 01
Blood Adv,
Int J Radiat Oncol Biol Phys, 2020 May 22
The New England journal of medicine, 2017-12-28
Radiother Oncol, 2021 Dec 7
Int J Radiat Oncol Biol Phys, 2021 Dec 1
Int J Radiat Oncol Biol Phys, 2022 Dec 20
Transplant Cell Ther, 2022 Dec 30
Blood advances, 2020 Jul 28
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2022 Oct 26
Blood advances, 2020 Nov 24
Haematologica, 2023 Jun 15
N Engl J Med, 2022 Dec 11
J Clin Oncol, 2022 Dec 22
Blood Adv, 2022 May 10
Blood, 2022 Dec 15
Proc Natl Acad Sci U S A, 2019 Apr 15
N Engl J Med,
Blood, 2022 Mar 03
Lancet, 2021 Jun 24
N Engl J Med, 2023 Jun 05
N Engl J Med, 2023 Feb 10
Lancet Oncol, 2021 Dec 03
Lancet, 2021 Jun 04
Experimental hematology & oncology, 2022 Feb 28
J Hematol Oncol, 2022 Mar 26
Blood advances, 2022 May 10