Nephrology

Glomerulonephritis

Questions discussed in this category

Are there patients with granulomatosis with polyangiitis on maintenance rituximab therapy for whom you do not co-administer glucocorticoid therapy?

2 Answers available

Do you extend the duration of maintenance therapy past 24 months for patients with ANCA glomerulonephritis who have multiple organ involvement?

2 Answers available

For patients with suspected complement-mediated TMA, are there specific clinical or laboratory parameters that can help guide the decision for starting empirical treatment (e.g., eculizumab) while awaiting the results of complement testing?

1 Answer available

Do you prefer a mycophenolate or tacrolimus based glucocorticoid-sparing regimen for patients with minimal change disease?

2 Answers available

Do you pursue a skin biopsy or kidney biopsy in patients whom you suspect have X-linked Alport syndrome?

2 Answers available

In which patients with MGUS do you recommend a kidney biopsy to evaluate for MGRS?

2 Answers available

In which patients with suspected IgA nephropathy and microalbuminuria would you recommend a kidney biopsy?

1 Answer available

What else do you consider in the differential diagnosis for pulmonary-renal syndromes if there is low clinical and serologic evidence of AAV, Goodpasture's or other rheumatologic disease (SLE, RA, APS, Scleroderma)?

2 Answers available

Would you treat a patient aggressively for lupus nephritis if they have persistent proteinuria over 1 gram but cannot get a timely kidney biopsy?

3 Answers available

What is your approach for steroid dosing for patients with ANCA vasculitis on induction treatment with rituximab, avacopan, and glucocorticoid therapy?

1 Answer available

What would be the clinical role of SGLT-2 inhibitors for lupus nephritis given it has an indication for proteinuria related to CKD?

5 Answers available

What are some measures to prevent flares of loin pain-hematuria syndrome?

1 Answer available

When would you consider a kidney biopsy in a patient with longstanding diabetes and hypertension (baseline creatinine 4-5, 4+ proteinuria) who was recently found to have dsDNA positivity?

1 Answer available

Would you check ANCA titers in a patient with a history of PR-3-ANCA glomerulonephritis in remission and a stable creatinine but with recurrent microscopic hematuria?

6 Answers available

Are there instances when you would pursue a kidney biopsy in a pregnant patient instead of waiting to perform the procedure post-delivery?

2 Answers available

Is there a role for eculizumab in the management of refractory lupus nephritis?

3 Answers available

Do you think there would be benefit in using sparsentan over irbesartan for FSGS given a higher percentage of patients with partial remission of proteinuria on sparsentan despite no significant difference in eGFR slope in the DUPLEX Trial?

PMID 37921461

2 Answers available

Do you consider starting hydroxyurea in a patient with hemoglobin S-beta thalassemia with chronic kidney disease secondary to FSGS?

No transfusion dependence but has hemoglobin in the 8-9 g/dl range.

1 Answer available

What are your top takeaways from ASN 2023?

2 Answers available

Are there instances when you would recommend obtaining a 24 hour urine protein measurement in place of spot urine protein studies in patients with acute kidney injury and proteinuria?

1 Answer available

Are there instances when you recommend obtaining more than 2 kidney cores when performing a native kidney biopsy?

2 Answers available

Is there a role for a kidney biopsy in patients diagnosed with Fabry disease through genetic testing?

2 Answers available

Would you recommend mycophenolate mofetil for patients with progressive IgA nephropathy who do not tolerate corticosteroids?

Based on the results of the MAIN trial; Hou et al., PMID: 36745456

2 Answers available

Is there a kidney length for which you would no longer recommend attempting a kidney biopsy due to safety concerns and lack of diagnostic yield?

1 Answer available

Would you recommend proceeding with a kidney biopsy for patients' with Waldenström's macroglobulinemia who have hematuria and normal kidney function?

2 Answers available

Do you recommend a kidney biopsy in a patient with myelodysplastic syndrome diagnosed two years prior who develops new onset proteinuria?

1 Answer available

How would you manage a patient with CKD4 due to lupus nephritis of unknown class who develops AKI requiring hemodialysis and nephrotic range proteinuria and is found to have atrophic kidneys on imaging?

2 Answers available

What is your approach to patients with membranous glomerulonephritis who have persistently elevated PLA2R titers but largely improved proteinuria and creatinine?

1 Answer available

Do you recommend obtaining a vasculitis work up for all patients seen for chronic kidney disease who are without a kidney biopsy?

1 Answer available

How do you approach COVID-19 vaccination in those with a prior history of glomerular disease?

2 Answers available

Would you add an SGLT2 inhibitor to augment diuresis during a hospitalization in a patient with nephrotic syndrome, an eGFR above 30 mL/min/1.73m2, and refractory hypervolemia on an intravenous loop diuretic?

1 Answer available

Are there cases of glomerulonephritis where you do not perform a kidney biopsy in a patient deemed safe to undergo the procedure?

1 Answer available

When is a kidney biopsy warranted in a patient with possible scleroderma renal crisis?

1 Answer available

Do you use both rituximab and plasmapheresis in patients with recurrent primary FSGS within three months of kidney transplantation?

1 Answer available

Papers discussed in this category

Kidney Int Rep, 2021 Oct 06

COVID-19 Vaccination and Glomerulonephritis.

Kidney360, 2023 Mar 01

COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry.

Kidney Int, 2022 Sep 10

Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased.

Kidney360, 2021 Dec 03

COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry.

Nephrol Dial Transplant, 2022 Jul 26

Perspective on COVID-19 vaccination in patients with immune-mediated kidney diseases: consensus statements from the ERA-IWG and EUVAS.

Clin Kidney J, 2021 Dec 21

Clinical spectrum of gross haematuria following SARS-CoV-2 vaccination with mRNA vaccines.

Clin Exp Nephrol, 2021 Nov 13

Gross hematuria after SARS-CoV-2 vaccination: questionnaire survey in Japan.

Kidney Int, 2021 Sep 14

COVID-19 vaccination followed by activation of glomerular diseases: does association equal causation?

J Am Soc Nephrol, 2022 Nov 04

A Population-Based Analysis of the Risk of Glomerular Disease Relapse after COVID-19 Vaccination.

J Am Soc Nephrol, 2020 Jul 17

Kidney Biopsy Findings in Patients with COVID-19.

Am J Transplant, 2021 Feb 23

Rituximab for recurrence of primary focal segmental glomerulosclerosis after kidney transplantation: Results of a nationwide study.

Transplantation, 2009 Aug 15

Use of rituximab in focal glomerulosclerosis relapses after renal transplantation.

Rheumatology international, 2017 Mar 03

Expanding the therapeutic options for renal involvement in lupus: eculizumab, available evidence.

Rheumatology (Oxford, England), 2015 Aug 27

Eculizumab as rescue therapy in severe resistant lupus nephritis.

Journal of the American Society of Nephrology : JASN, 2017-02

A Proposal for a Serology-Based Approach to Membranous Nephropathy.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2017 Mar-Apr

Biopsy of small kidneys: A safe and a useful guide to potentially treatable kidney disease.

Clinical journal of the American Society of Nephrology : CJASN, 2017 May 04

Clinical and Histopathologic Characteristics Associated with Renal Outcomes in Lupus Nephritis.

Kidney international reports, 2021 Jan 06

Spectrum of Kidney Involvement in Patients with Myelodysplastic Syndromes.

Clin J Am Soc Nephrol, 2018 Jul 6

Kidney Involvement of Patients with Waldenström Macroglobulinemia and Other IgM-Producing B Cell Lymphoproliferative Disorders.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019 Jul 19

Dysproteinemia and the Kidney: Core Curriculum 2019.

Kidney research and clinical practice, 2021 Nov 29

Fabry nephropathy before and after enzyme replacement therapy: important role of renal biopsy in patients with Fabry disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013 Jun 19

Severe lupus nephritis: the predictive value of a ≥ 50% reduction in proteinuria at 6 months.

Clinical journal of the American Society of Nephrology : CJASN, 2020 Mar 09

The Evolving Role of Calcineurin Inhibitors in Treating Lupus Nephritis.

Kidney international, 2021 Apr 18

A pre-specified analysis of the DAPA-CKD trial demonstrates the effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy.

The New England journal of medicine, 2022 Nov 04

Empagliflozin in Patients with Chronic Kidney Disease.

Lupus science & medicine, 2020 Feb 18

Prediction of prognosis and renal outcome in lupus nephritis.

N Engl J Med, 2021 Feb 18

Avacopan for the Treatment of ANCA-Associated Vasculitis.

Lupus Sci Med, 2018

Serum albumin at 1 year predicts long-term renal outcome in lupus nephritis.

Pediatric nephrology (Berlin, Germany), 2020 Nov 06

Clinical practice recommendations for the diagnosis and management of Alport syndrome in children, adolescents, and young adults-an update for 2020.

The Journal of molecular diagnostics : JMD, 2012 Aug 21

Skin biopsy is a practical approach for the clinical diagnosis and molecular genetic analysis of X-linked Alport's syndrome.

Annals of the rheumatic diseases, 2024 Jan 11

Rituximab as maintenance therapy for ANCA-associated vasculitides: pooled analysis and long-term outcome of 277 patients included in the MAINRITSAN trials.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2012-08

Cyclophosphamide without corticosteroids for treatment of severe systemic necrotizing vasculitis.

Current medical research and opinion, 2016-12

Corticosteroids: the knee jerk response.

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