Benign Hematology   

Is a BM biopsy a must when there is skin involvement? If tryptase level is mildly elevated but less than 20 would you recommend a BM biopsy?

Significant history of autoimmune diseases and DVT in family, recent PE/DVT for a month

Nonreliable INR, given hepatic coagulopathy

Also how would you manage this perioperatively?

The patient has no known history of autoimmune disease.

For example, a patient with a bone marrow biopsy that shows normocellular bone marrow. Prior management with leflunomide and HCQ with neutropenia attr...

Is SLE-related APLS managed differently in terms of anticoagulation?

Although testing was not indicated, what do u do with these results? Other hypercoagulability work up negative

Would the answer differ if the index event was arterial vs venous? 

If work-up is sent and the patient is found to have a persistently positive antiphospholipid antibody, particularly lupus anticoagulant, would you con...

If so, is there one type of antibody that is more likely to cause this false positive test? 

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

Is it time limited since it may have been triggered by the pregnancy or is it indefinite since it is APLS associated?

I.e., what constitutes well-controlled cancer, IBD, nephrotic syndrome, etc. What other diseases do you put in this category (obesity, autoimmune dise...

(e.g. beta 2 glycoprotein IgM > 20 but <40)

How would the approach differ if the patient had a significant bleeding phenotype vs only minor bruising and mucosal bleeding?

If so, how long after diagnosis do you do so? 

Do you routinely check IgA anticardiolipin and beta-2 glycoprotein antibody IgA in your practice? And how would a positive result change your manageme...

e.g. DITP from eptifibatide after a cardiac intervention

What if the patient is triple-positive or has continued seropositivity on repeat lab testing? What is the appropriate interval of monitoring and does ...

While low-dose aspirin for primary thrombosis prevention in aPL without APS is not typically recommended outside cardiovascular prevention guidelines ...

What if this was "triple-negative" antiphospholipid syndrome?