Medical Oncology   

Is there a target IgG level to aim for? What should hematologists be aware of in monitoring these patients?

What is your most and least preferred? In case of cancer in remission and in case of non-remission?

Cervical cancer FIGO stage IIIC2. Bloodwork shows elevated ESR and CRP. 

As immune checkpoint inhibitors have expanded into the neoadjuvant breast cancer setting, severe and unexpected autoimmune toxicities may cause delays...

If so, what dose-fractionation do you utilize? What other factors do you take into consideration?

There was a recall on viscous lidocaine and many of our patients cannot find it. What would you recommend as alternatives?

Does the type of autoimmune disease (ex IBD, rheumatoid arthritis, interstitial lung disease) matter?

Assuming no symptoms of TB, should patients be treated for latent TB prior to starting TNF inhibitors or other immunosuppressive agents?

Patient already on methotrexate and plaquenil.   

How is this entity distinct from other secondary HLH entities? 

Are there any instances where you would prefer a biosimilar rather than the reference product? 

Would you favor the use of any particular biologics over others?

Would the checkpoint inhibitor still work if blocking only that portion of the inflammatory cascade as opposed to more global blockade with steroids?

What is the risk of pregnancy loss in absence of anticoagulation? What would you suggest if the patient had anticoagulation in prior pregnancies and r...

Is there role for IVIG? Would you alter the dose or time course of steroid therapy?

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

e.g. DITP from eptifibatide after a cardiac intervention

For medical oncologists, would you offer a PD-1/L1 inhibitor? For other subspecialties, how would you counsel the oncologist regarding the risk of usi...

How do you decide if it may be safe to continue immunotherapy?

Would you use immunosuppression in patients several years after curative treatment for melanoma?

Would active vasculitis present a contraindication to therapy?

Do you follow the 2019 EULAR Guidelines that SLE patients with asymptomatic, positive aPL should be on low-dose ASA?

What non-pharmacological interventions do you recommend? Do you routinely prescribe prophylactic laxatives to patients initiating opioids? How do you ...

What if this was "triple-negative" antiphospholipid syndrome?

Acknowledging that there is no time for good trials yet in this setting

Do you re-challenge with nivolumab alone, change from nivo 1/ipi 3 to nivo 3/ipi 1 upon re-challenge, or stop immunotherapy altogether if grade 3?&nbs...

How about those with metastatic disease eager to maintain quality of life? Do you risk progression of disease if the TNF blocker is re-started?

Is IO related pneumonitis in the radiation field or more diffuse?