Antiphospholipid Syndrome   

Questions discussed in this category

Patient with negative blood cultures, completed 6 weeks of IV antibiotics and vegetation persists. CT imaging without evidence of malignancy. No evide...

If so, would you start immediately or wait for the second set of labs to confirm before initiating blood thinners?

Significant history of autoimmune diseases and DVT in family, recent PE/DVT for a month

Do you wait 12 weeks for confirmation to begin treatment if patient is declining?

If work-up is sent and the patient is found to have a persistently positive antiphospholipid antibody, particularly lupus anticoagulant, would you con...

If so, is there one type of antibody that is more likely to cause this false positive test? 

What is the risk of pregnancy loss in absence of anticoagulation? What would you suggest if the patient had anticoagulation in prior pregnancies and r...

Do you routinely check IgA anticardiolipin and beta-2 glycoprotein antibody IgA in your practice? And how would a positive result change your manageme...

What if the patient is triple-positive or has continued seropositivity on repeat lab testing? What is the appropriate interval of monitoring and does ...

While low-dose aspirin for primary thrombosis prevention in aPL without APS is not typically recommended outside cardiovascular prevention guidelines ...

Especially in a triple-positive patient with an acute ischemic stroke who may have urgency for anticoagulation with high bleeding risk and severe thro...

Papers discussed in this category

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2016-04

Blood, 2018 Jul 12

Ann. Intern. Med., 2019 Oct 15

Annals of the rheumatic diseases, 2019-10


Clinical immunology (Orlando, Fla.), 2019-09

Seminars in arthritis and rheumatism, 2019-08

Journal of thrombosis and haemostasis : JTH, 2018-06-07

Ann Rheum Dis,

Journal of the American Society of Nephrology : JASN, 1993-07

Arthritis and rheumatism, 2013-02

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2014-02

Lupus, 2018-03


Arthritis Rheum,

Rheumatology (Oxford), 2021 May 18

Am J Transplant, 2013 Jun 13

Thromb Res, 2021 Jun 25

Lancet Haematol,

Current rheumatology reports, 2018-09-10

Nat Rev Cardiol, 2019 Jun 26

Arthritis Rheum,

Thromb Haemost, 2020 Jul 21

Autoimmun Rev, 2017 Sep 09

Lupus, 2021 May 27

Arthritis and rheumatism, 2007-07

Stroke, 2014-07

Cochrane Database Syst Rev, 2020 Oct 12

Archives of internal medicine, 1997-10-13

Lupus, 2011-02

Stroke, 2021 May 24

J Autoimmun, 2018 Feb 13

Int J Med Sci, 2009 Dec 05

J Rheumatol, 2017 May 15

J Thromb Haemost, 2020 Nov 29

Front Cardiovasc Med, 2021 Aug 03

Melanoma research, 2017-04

Lung Cancer, 2021 Aug 03

SAGE Open Med Case Rep, 2020 Nov 06

Lupus Sci Med, 2018 Sep 25

J Thromb Haemost, 2009 Mar 05

Blood, 2013-08-01

Circulation, 2003 Jun 17

Haematologica, 2007 Feb

PLoS One, 2015 Dec 30

Rheumatology (Oxford, England), 2002-08

J Thromb Haemost, 2022 Jul 14

Gastroenterology, 2019 Apr 12

Arthritis and rheumatism, 2012-07

Blood, 2022 Jun 23

Best practice & research. Clinical rheumatology, 2019 Dec 19

Lupus, 2018 Oct 05

Annals of the rheumatic diseases, 2023 Aug 28

Arthritis Rheumatol, 2020 Apr

Rheumatology and therapy, 2021 Jan 09

Arthritis & rheumatology (Hoboken, N.J.), 2023 Aug 28

Autoimmunity reviews, 2017 Feb 13

Thrombosis research, 2023 Feb 10

Lupus, 2017 Mar 29

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019 Jan 17

Nephrology (Carlton, Vic.), 2019 Oct 23