Questions discussed in this category
Cervical cancer FIGO stage IIIC2. Bloodwork shows elevated ESR and CRP.
Would you consider this stage IVA (spread to adjacent organ) or IVB (spread to distant organ)? For instance, would the presence of direct lumbar verte...
The 4 cm cuff recurrence occurred 3 years after definitive treatment with hysterectomy and vaginal cuff brachytherapy to 21 Gy. The recurrence had a c...
If so, what do you typically prescribe?
The trial showed an overall survival benefit of 8% at 5 years with induction chemotherapy (80% vs 72%) utilizing at least 5 cycles of carboplatin-pacl...
Consider treatment of stage IVB cervical cancer with systemic therapy and local pelvic radiation therapy as in Perkins et al., PMID 31810653.
Considering this is stage IV disease, do your recommendations for definitive or adjuvant treatment (after surgery) change?
MRI pelvis shows a 3.5 cm primary that appears infiltrative and without clear parametrial extension on MRI. Staging PET negative.
Is there any ...
When would you use 5-fluorouracil instead of, or in addition to, cisplatin during chemoradiation?
When would you use 5-fluorouracil instead of, or in addition to, cisplatin during chemoradiation? When, if ever, would you offer adjuvant hysterectomy...
Do you include pembrolizumab with platinum-taxane + bevacizumab or reserve it as a second line option?
Assuming minimal toxicities except fatigue from long, recurrent infusions.
Do you try to keep Hb> 10 or 12? Or somewhere in between?
Previously received pelvic EBRT and intracavitary brachytherapy. IORT was administered to the node-positive side wall at the time of exenteration.
Initially treated with definitive chemoRT but recurred with distant mets. Completed 6 cycles carb/tax/bev with minimal toxicity. Excellent performance...
Lung is biopsy proven met cervix, SBRT is planned.
Patient did not previously receive para-aortic radiation. Considering RT vs RT + chemo vs chemo alone
Recurrence was 2cm and PET confirmed local. Excision with positive margins. Current plan for salvage whole pelvic RT and vaginal cuff brachytherapy +/...
If confirmed neuroendocrine and PD-L1 pending, how would you treat?
This has been a common practice in the community. Is there a benefit for certain patients?
Would you be more or less likely to use a cisplatin-containing regimen if a patient had previously responded to chemoradiation with concurrent cisplat...
Does the phase II KN-158 provide sufficient evidence to change management?
Should this be done at the time of recurrence or after failure of 1st line therapy for recurrence?
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Papers discussed in this category
JAMA Netw Open, 2021 Apr 01
Clinical cancer research : an official journal of the American Association for Cancer Research, 2015-12-15
J. Clin. Oncol., 2011 Mar 28
BMC Cancer, 2017 Apr 28
N. Engl. J. Med.,
Lancet (London, England), 2017-10-07
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-10
J Clin Oncol, 2019 Nov 04
Lancet Oncol, 2021 Apr 09
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000-04
Gynecologic oncology, 1998-08
Gynecologic oncology, 2011-07
BMC Cancer, 2018 May 04
Gynecol Oncol, 2017 Sep 24
N Engl J Med, 2021 Sep 18
N Engl J Med, 2022 Jan 19
Gynecol Oncol, 2022 Oct 15
Am J Surg Pathol, 2015 Nov
Eur J Surg Oncol, 2022 Mar 25
Gynecologic oncology, 2003-06
American journal of obstetrics and gynecology, 2007-11
BMC Cancer, 2021 Oct 11
Gynecol Oncol, 2019 Jan 29
Int J Gynecol Cancer, 2018 Jan
BMB Rep, 2022 Sep
J Gynecol Oncol, 2019 Sep 17
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-03-01
Clinical Medicine Insights. Oncology, 2022 Jun 24
N Engl J Med, 2023 Mar 27
N Engl J Med, 2023 Mar 27
Gynecologic oncology, 2004-03
The New England journal of medicine, 2018-11-15
Int J Gynecol Cancer, 2021 Sep 07
J Clin Oncol, 2023 Jan 30
Rheumatology (Sunnyvale, Calif.), 2015 May 07
Annals of the rheumatic diseases, 2013 Jul 10
Clin Transl Radiat Oncol, 2018 Jan 11
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2022 Mar
Gynecologic oncology, 2019-03