NCI-CCC Thoracic Tumor Board Question   

Questions discussed in this category


In light of CheckMate 816 and IMpower010 and FDA approval for neoadjuvant chemo-nivolumab and adjuvant chemo-atezolizumab, how do you decide which sys...

NGS without any actionable mutations and PD-L1 TPS 15%. Would you offer chemotherapy, radiation, or immunotherapy and, if so, in what order?

Patient has been on pembrolizumab and had two symptomatic soft tissue mass treated with radiation. 

Do you routinely offer post-operative adjuvant radiation in addition to chemotherapy?  Are the results of the recently published negative phase ...

Would you consider afatinib? Afatinib has shown some activity in NRG1 fusion + patients but amplifications is unclear. 

I am considering every 6 week pembrolizumab dosing in patients >70 years old in whom I want to reduce clinic visits for, especially in the context ...

Are there any data to support a specific TKI therapy for non-T790M exon 20 mutations/insertions?

The patient remains without evidence of systemic disease outside of the CNS on serial imaging. Would you continue treating with SRS as lesions appear,...

Should staging and treatment decisions be made based on imaging alone?

Would you offer adjuvant TKI following ADAURA data?  Or proceed with durvalumab based on PACIFIC data?


Papers discussed in this category


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Lancet Oncol, 2021 Dec 15

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Lancet (London, England), 2019-05-04

J Clin Oncol, 2020 May 10

J Thorac Oncol, 2021 Oct 12

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-11-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-11-01

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Cancer, 2015 Jan 06

Eur J Cardiothorac Surg,

Lancet Oncol.,

Br J Cancer,

The New England journal of medicine, 2016-03-03

Cancer immunology, immunotherapy : CII, 2017-01

Cancer, 2017-06-01

Journal of the American Academy of Dermatology, 2019-07-11

J Immunother,

Oncologist, 2020 Feb 11

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015-09

J Thorac Dis,

The New England journal of medicine, 2018-12-06

Lancet, 2019 Oct 04

Ann Oncol, 2019 Oct 1

Int J Cancer, 2020 Dec 21

Adv Ther, 2020 Oct 29

Lancet, 2021 Jan 21

Ann Oncol,

N Engl J Med, 2017 Nov 16

N Engl J Med, 2020 Sep 19

Lancet, 2021 Sep 20

N Engl J Med, 2022 Apr 11