Pharmacology

Questions discussed in this category

Are there any concerns utilizing apremilast for psoriatic arthritis in patients who are also taking roflumilast for COPD?

1 Answer available

When would you consider additional testing for NUDT15 and other polymorphisms related to 6-MP/6-TG metabolism, if not guided by a study protocol?

2 Answers available

What is the role of non-prednisone oral glucocorticoids in the management of systemic rheumatologic disease?

Such as oral methylprednisolone, dexamethasone, prednisolone, etc.

1 Answer available

Do you stop PPI when starting patients on immunotherapy?

1 Answer available

How would you approach a patient who has developed neutropenia with the combination of trastuzumab/pertuzumab in the adjuvant setting?

Would you consider the discontinuation of either anti-HER2 agent or both?

1 Answer available

What is your approach to the management of hot flashes in a patient who wants to use herbal medicine?

Do you allow patients with breast cancer on tamoxifen to use black cohosh?

2 Answers available

What is the best way to approach elevated liver enzymes in patients treated with combination TKI and immunotherapy?

Are there any clinical features that can inform etiology/which medication to hold?

1 Answer available

Papers discussed in this category

Br J Cancer, 2020 Jun 26

Axitinib plus immune checkpoint inhibitor: evidence- and expert-based consensus recommendation for treatment optimisation and management of related adverse events.

Ann Pharmacother, 2021 Jul 20

Impact of Proton Pump Inhibitor Use on the Effectiveness of Immune Checkpoint Inhibitors in Advanced Cancer Patients.

Ann Transl Med,

The effect of proton pump inhibitor uses on outcomes for cancer patients treated with immune checkpoint inhibitors: a meta-analysis.

Can Fam Physician,

Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline.

Pharmacogenomics,

Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe.

Pediatr Blood Cancer, 2011 Feb 22

A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia.

Pediatr Blood Cancer, 2011 Jul 27

Pharmacogenetics, cost of genotyping, and guidelines for individualizing therapy with mercaptopurine in pediatric acute lymphoblastic leukemia.

Int J Hematol, 2021 Oct 28

NUDT15 genetic testing-guided 6-mercaptopurine dosing in children with ALL likely to be cost-saving in China.

Pharmacogenet Genomics,

Cost-effectiveness analysis of pretreatment screening for NUDT15 defective alleles.

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