Re-irradiation   

Questions discussed in this category


The 4 cm cuff recurrence occurred 3 years after definitive treatment with hysterectomy and vaginal cuff brachytherapy to 21 Gy. The recurrence had a c...

Does the time interval between the intial RT and recurrence influence your decision? What time interval would you feel is appropriate? What dose would...

What special considerations or precautions would you keep in mind when considering re-irradiation? The prior radiation was post prostatectomy RT. ...

If records have been destroyed, how do you factor prior pelvic radiation for prostate cancer into your decision?

Do you assume some recovery since the prior course of RT? If so, how much over what time period?

How does your approach change for same lung but now a different lobe v. different lung? How do you adjust your constraints?

Does your recommendation change depending on the disease-free interval?

For example, would you treat the entire length of the femur after prophylactic intramedullary rod fixation for a femoral neck metastasis?

If a WHO II glioma was treated with RT and recurs and is now a WHO III glioma would you retreat with radiation?  What would be your target volume...

What dose fractionation and volume do you use? What factors influence your decision?

Is there any further benefit of hyperthermia monotherapy, for example, continuation of hyperthermia after the course of radiation has completed?

How does grade, margin status, and previous radiation dose factor into the recommendation? 

Assuming CSF is negative for neoplastic cells would you: Re-irradiate gross disease only? Re-irradiate posterior fossa only? Re-irradiate the entir...

If choosing systemic therapy, do you prefer bevacizumab with or without irinotecan? Have you used anti-PD1 agents (e.g. nivolumab) off label? 

If the patient had RT 3 months prior and had a revision surgery, would you offer RT again? If so, which dose and fractionation would you use?

If a patient has increasing FLAIR and T1 enhancing activity, should both be included in the treatment volume? What factors to you consider in making y...

Is there any literature supporting that a gentle fractionation/bid regimen (i.e., 1.5Gy bid x 30 = 45Gy) is safer than a standard fractionation  ...

Eight years after brachytherapy for a low risk prostate cancer, a patient has unresectable high grade squamous cell carcinoma of the bladder. Should I...


Papers discussed in this category


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-06-20

J Neurooncol, 2014 Jan

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017-10

J Neurooncol, 2018 Dec 04

Yonsei Med J,

Practical radiation oncology, 2015

Radiother Oncol, 2016-10-01

Oral oncology, 2016-09

J Radiosurg SBRT,

International journal of radiation oncology, biology, physics, 2018-03-01

International journal of radiation oncology, biology, physics, 2018-03-01

International journal of radiation oncology, biology, physics, 2018-03-01

Technol Cancer Res Treat, 2012 May 07

International journal of radiation oncology, biology, physics, 2011-03-15

Eur J Cancer, 2012 Sep

J. Clin. Oncol., 2008-12-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-04-01

Translational oncology, 2013-08

Acta Oncol, 2006-01-01

J. Cancer Res. Clin. Oncol., 2015-07-01

Semin Radiat Oncol, 2017-07-01

Journal of neuro-oncology, 2012-01

American journal of clinical oncology, 2012-02

Eur. J. Cancer, 2017-03-01

Radiation oncology (London, England), 2015-02-18

Gynecologic oncology, 2019-03