Her2-negative breast cancer   

Questions discussed in this category

PFS curves appear similar between the AKT-altered vs overall study population in the trial publication. Is there any additional information available ...

MONARCHE added an amendment to their protocol to exclude inflammatory breast cancer so they technically would not qualify for the trial though it's ha...

If NGS was positive would you treat with HER2 directed therapy? How, if at all, would you incorporate T-DXd into this treatment paradigm?

Can you use 50 mg BID if intolerant to 150 mg and 100 mg dosing? Any tips for side effect management to help patients stay on full duration?

MonarchE shows statistically significant improvement in IDFS and DRFS, but the magnitude of absolute benefit is modest (3-year IDFS and DRFS rates = 5...

Majority of patients on MonarchE received neoadjuvant/adjuvant chemo.  Does the availability of abemaciclib impact your decision to offer chemo ...

Should this be sent on initial biopsy or on surgical pathology? What if an initially high risk patient has good risk findings post-operatively?What ha...

Papers discussed in this category

J. Clin. Oncol., 2020 Sep 20

Clin Cancer Res, 2017 Mar 07

Lancet Oncol, 2019 Dec 11

Annals of Oncology, 2021 Sep 29

Ann Oncol,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-09-01

Ann Oncol, 2022 Mar 23

Journal of the National Cancer Institute, 2011-11-16

Archives of pathology & laboratory medicine, 2016-01

Lancet Oncol,

J Clin Oncol, 2009 Apr 20

Clin Cancer Res,

N Engl J Med, 2021 Jun 03

Br J Cancer, 2021 Jan 21

Clin Cancer Res, 2022 Jan 19

JCO Precis Oncol, 2019 Nov 15

N Engl J Med, 2022 Jun 05

Lancet, 2022 Dec 06

The New England journal of medicine, 2023 Jun 01

The Journal of clinical investigation, 2010-07

Science translational medicine, 2015-04-15

Cancer discovery, 2020 May 13

Clinical cancer research : an official journal of the American Association for Cancer Research, 2022 Mar 01

Molecular cancer therapeutics, 2012 Jan 31

Signal transduction and targeted therapy, 2021 Dec 16

International journal of molecular sciences, 2021 Dec 16