Questions discussed in this category
What were your “top 3” presentations/studies coming out of the meeting this year and how will it impact your own clinical practice?
...
Are there factors which would make you more likely to use atezo/bev vs durva/treme vs TKI?
Would portal hypertensive gastropathy or colopathy sway you away from using it?
Or offer resection followed by adjuvant therapy?
Will the results of the recently published randomized comparison of proton beam therapy (PBT) vs. transarterial chemoembolization (TACE) change the wa...
Is there a difference in efficacy if dose is given later point during the course of therapy?
How do you sequence systemic treatment options for in patients with Child's Pugh B (or greater) in context of IMbrave150 and HIMALAYA?
When do you in...
Would you try atezolizumab/bevacizumab or switch to a TKI?
For example in a patient with a history of PE?
i.e. EGD surveillance for varices?
What parameters do you use to decide to treat beyond progression? Is there any efficacy data from this specific study subgroup in IMbrave150?
ex. VEGFR2 expression, inflammatory signature, PDL1, etc.
Do you continue atezolizumab alone? Would you avoid anticoagulation?
In light of the SIRveNIB trial results and now IMbrave150, what is the role of intra-arterial therapy now?
Do you screen even asymptomatic patients?
Does the Child Pugh score factor in your treatment decision, i.e. Child Pugh score C?
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Papers discussed in this category
Clin. Cancer Res., 2015 Oct 23
Invest New Drugs, 2015 Apr 12
J Hepatol, 2021 May 26
N Engl J Med, 2020 May 14
NEJM Evidence, 2022 June 6
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-04-10
Cancer, 2019-09-15
Liver Cancer, 2019 Sep 18
The New England journal of medicine, 2018-07-05
Lancet (London, England), 2018-03-24
J Gastroenterol, 2019 Nov 12
Am Heart J, 2010 Sep 18
N Engl J Med,
Lancet (London, England), 2017-01-07
The Lancet. Oncology, 2019-02
JAMA Oncol, 2020 Dec 10
Hepatology, 2019 Oct 14
Annals of oncology : official journal of the European Society for Medical Oncology, 2024 Feb 19
Br J Cancer, 2021 Feb 03
Hepatogastroenterology, 2013 Jan 16
Medicine (Baltimore),
Cancers (Basel), 2022 Mar 28
The New England journal of medicine, 2013-10-31
N. Engl. J. Med.,
Lancet, 2021 Jun 05
Eur J Cancer, 2018 Aug 24
NEJM Evidence, 2022 Jun 1
Future Oncol, 2020 Apr 30
N Engl J Med, 2023 Jun 04
Lancet Oncol, 2021 May 04
Lancet Oncol, 2023 Jun 02
NEJM evidence, 2022 Jun 06
Int J Radiat Oncol Biol Phys, 2019 Oct 1
Frontiers in oncology, 2020 Mar 24
International journal of radiation oncology, biology, physics, 2023 Apr 08
Cancer, 2023 Jul 28