Psychopharmacology

Questions discussed in this category

How do you approach mood stabilizer selection for older adults with bipolar II disorder?

When do you pursue dose reduction versus medication discontinuation versus switching agents in this population? How do you weigh risks of mood stabili...

2 Answers available

When do you consider low-dose buprenorphine for the management of treatment resistant depression?

How have you prescribed it and if so what dosing strategy? Where does it fall on your pharmacologic approach to treatment resistant depression?

2 Answers available

What is your approach to augmenting treatment for depressive disorders in those continuing to take a tricyclic antidepressant at baseline due to historical effectiveness?

How does the presence of a TCA impact your augmenting medication choices? Which herbal supplements carry more risk when combined with a TCA? Which are...

2 Answers available

Which patients do you think would benefit most from xanomeline-tropsium (Cobenfy) monotherapy?

How does the general goal of reducing anticholinergic burden in schizophrenia play into your decision?

3 Answers available

How would you decide between escalation to clozapine vs xanomeline-tropsium (Cobenfy) for treatment-resistant schizophrenia?

4 Answers available

What opportunities do you see for combining xanomeline-tropsium (Cobenfy) with other anti-psychotic agents?

E.g. LAIs, clozapine

2 Answers available

What strategies have you found effective for obtaining insurance approval for xanomeline-tropsium (Cobenfy)?

1 Answer available

What is your approach to using newer atypical antipsychotics in the treatment of schizophrenia?

E.g., Latuda (lurasidone), Fanapt (iloperidone), Vraylar (cariprazine), Rexulti (brexpiprazole), Caplyta (lumateperone), or Saphris (asenapine), Lybal...

3 Answers available

What treatment and management recommendations do you have for amphetamine-induced skin picking disorder without insight?

6 Answers available

How do you approach titration or transitioning to Cobenfy in patients currently on an antipsychotic?

Are there any special concerns for antipsychotics with a higher anticholinergic burden?

2 Answers available

How do you approach diagnosing suspected early tardive dyskinesia with minimal positive findings on AIMS examination?

2 Answers available

What is your pharmacological approach to treating depressive disorders in patients who develop serotonin toxicity?

How does the development of serotonin toxicity/syndrome change your usage of serotonergic medications? Which medications/classes of medications do you...

2 Answers available

How do you approach managing intolerable vivid dreams as a side effect of SSRIs?

2 Answers available

How do you approach liver function testing and monitoring when using xanomeline/tropsium (Cobenfy)?

Do you obtain baseline liver function testing prior to starting Cobenfy? What would consistute a level of baseline liver dysfunction that is contraind...

1 Answer available

When do you consider using Uzedy, the subcutaneous long-acting injectable version of risperidone?

1 Answer available

When do you recommend HLA testing prior to prescribing lamotrigine, carbamazepine, or oxcarbazepine to patients of Asian descent?

3 Answers available

What is your experience in the efficacy of vortioxetine for treating anxiety disorders?

1 Answer available

How do you use lithium levels to adjust treatment during mania?

2 Answers available

When is the best time to get a valproate level if a patient is taking Depakote DR once daily?

3 Answers available

How do you decide which commercially available pharmacogenetic test to use for your patients?

Are there specific testing companies you prefer? How do you weigh the differences between options such as GeneSight and Genomind? In what situations w...

2 Answers available

How do you manage polyuria and polydipsia from lithium?

2 Answers available

How do you counsel/approach antidepressant use in patients planning to utilize or self-administer psychedelics for chronic PTSD or depression?

With patients increasingly accessing psychedelics through online forums or home-grown sources for chronic PTSD and depression, how should psychiatrist...

1 Answer available

How do you view the risk of tardive dysinesia and other side effects in your female patients with treatment-resistant depression who are stable on an atypical antipsychotic?

Given the concern about potential TD in female patients treated with second-generation atypical antipsychotics as an adjunct to antidepressants, are y...

5 Answers available

What is your approach to delayed or inhibited ejaculation related to SSRI sexual dysfunction?

What are other ways to treat this beyond reducing the dose / switching medications? What interventions have you had the most success with?

1 Answer available

Would you consider prescribing NAC for a patient with OCD and a documented sulfa allergy?

2 Answers available

How do you approach agitation management, especially the use of neuroleptics in hospitalized patients with a prolonged QTc?

2 Answers available

How do you monitor patients who are symptomatically well-managed on clozapine with supratherapeutic drug levels?

2 Answers available

When do you consider pharmacogenetic testing to assist in the selection of antipsychotic medications?

In light of publication from Gras et al., PMID 40662264

1 Answer available

How do you manage nausea side effects in patients on cariprazine?

1 Answer available

How do you approach prescribing oxcarbazepine when the patient is on an oral contraceptive?

1 Answer available

When do you attribute tremors to lamotrigine?

3 Answers available

How do you decide between initiating antidepressants vs. hormone replacement therapy for post-menopausal depression?

2 Answers available

What types of cardiac conduction abnormalities would lead you to avoid using tricyclic antidepressants?

8 Answers available

Would you recommend CRRT instead of intermittent hemodialysis to prevent lithium rebound in a patient with lithium toxicity after an initial intermittent hemodialysis session?

4 Answers available

How do you manage withdrawal symptoms of SNRIs that exist even after slow taper?

2 Answers available

How will the removal of the clozapine REMS requirement change your clinical practice?

4 Answers available

When do you consider adding an antipsychotic for SSRI-refractory OCD, and which agent do you typically choose first?

2 Answers available

When do you consider antipsychotic augmentation of antidepressants for PTSD?

In light of publication from Davis et al., PMID 39693081.

1 Answer available

Would you consider changing management for a patient with bipolar disorder stable on an antipsychotic who is on anticoagulation after a recent PE or VTE?

How strong is the evidence that antipsychotic medication can increase the risk of venous thromboembolism and pulmonary embolus?

1 Answer available

Have you observed adverse mental health side effects in patients who start montelukast?

In light of the FDA warning about mental health side effects of the medication have you observed in particular any patients develop suicidal thoughts ...

6 Answers available

Do you tend to avoid the use of oral weight loss stimulant medications such as phentermine in obese patients on SSRI or ADHD treatments?

1 Answer available

How do you manage emotional blunting due to SSRIs/SNRIs?

7 Answers available

In your experience how does the dose of Remeron (mirtazapine) influence side effects like hunger and weight gain?

3 Answers available

What are your preferred methods for QTc calculation for normal, tachycardic and bradycardic heart rates?

1 Answer available

How do you cross-taper when switching from an SSRI to an SNRI?

2 Answers available

How frequently do you recommend EKGs in pediatric patients on antipsychotics, especially in patients taking antipsychotics with more QTc risk?