Questions discussed in this category
How is this entity distinct from other secondary HLH entities?
For example, a patient with a bone marrow biopsy that shows normocellular bone marrow. Prior management with leflunomide and HCQ with neutropenia attr...
Although testing was not indicated, what do u do with these results?
Other hypercoagulability work up negative
Would the answer differ if the index event was arterial vs venous?
Is a BM biopsy a must when there is skin involvement?
If tryptase level is mildly elevated but less than 20 would you recommend a BM biopsy?
I.e., what constitutes well-controlled cancer, IBD, nephrotic syndrome, etc. What other diseases do you put in this category (obesity, autoimmune dise...
(e.g. beta 2 glycoprotein IgM > 20 but <40)
How would the approach differ if the patient had a significant bleeding phenotype vs only minor bruising and mucosal bleeding?
If so, how long after diagnosis do you do so?
Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?
e.g. DITP from eptifibatide after a cardiac intervention
What if the patient is triple-positive or has continued seropositivity on repeat lab testing? What is the appropriate interval of monitoring and does ...
There are multiple difficulties that could be seen: steroids can precipitate a sickle cell crisis, vasculitis and sickle cell can produce similar clin...
What if this was "triple-negative" antiphospholipid syndrome?
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Papers discussed in this category
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2016-04
Blood, 2018 Jul 12
Ann. Intern. Med., 2019 Oct 15
Journal of thrombosis and haemostasis : JTH, 2018-06-07
Rheumatol Int, 2019 Apr 30
Clin Exp Rheumatol, 2012 Sep 25
Wien Klin Wochenschr,
J Rheumatol, 2006 Jul 01
Semin Arthritis Rheum,
Semin Hematol,
Blood Adv,
Autoimmun Rev, 2017 Sep 09
Lupus, 2021 May 27
Eur J Dermatol,
Blood, 2013-08-01
Circulation, 2003 Jun 17
Haematologica, 2007 Feb
PLoS One, 2015 Dec 30
Pediatric blood & cancer, 2011-01
Seminars in hematology, 2002-04
Blood, 2002 Jan 01
Ther Adv Musculoskelet Dis, 2020 Nov 24