Osteoarthritis

Questions discussed in this category

How do you weigh the risks and benefits of GLP-1 RAs in patients over age 65 specifically in regards to loss of muscle mass and osteoporosis?

How do you counsel patients about these risks? This question is part of our collaboration with ACR Convergence 2025 to preview a session from this ye...

1 Answer available

Would you offer re-irradiation LDRT for someone with osteoarthritis or tendinitis if symptoms recur?

If yes, what time frame would you potentially offer this? If they had complete relief in one joint and partial relief in another after 2 courses, woul...

2 Answers available

When in the treatment of OA do you think it is optimal to offer LDRT?

Many guidelines continue to list LDRT as a non-primary/secondary intervention; do you wait to offer LDRT until after trial of conventional primary int...

1 Answer available

Do GLP-1 agonists have measurable anti-inflammatory effects in diseases like RA or spondyloarthropathies beyond weight loss?

This question is part of our collaboration with ACR Convergence 2025 to preview a session from this year's meeting. This question is inspired by the u...

2 Answers available

When do you prefer bariatric surgery such as sleeve gastrectomy or gastric bypass over an initial trial of a GLP-1 receptor agonist in patients with severe obesity and painful knee or hip osteoarthritis?

This question is part of our collaboration with ACR Convergence 2025 to preview a session from this year's meeting. This question is inspired by the u...

1 Answer available

What is the role of the rheumatologist in recommending and providing GLP-1 medications to their patients given the benefits across many disease domains including osteoarthritis?

This question is part of our collaboration with ACR Convergence 2025 to preview a session from this year's meeting. This question is inspired by the u...

2 Answers available

Does your practice currently use low-dose radiation in the treatment of osteoarthritis?

In patients with bone metastases and osteoarthritis, if it is unclear if the pain is from cancer or OA, how do you decide on the radiation dose/fracti...

1 Answer available

In patients with severe osteoarthritis, can elevated alkaline phosphatase levels be attributed to increased bone turnover from advanced joint degeneration?

2 Answers available

Would you consider using LDRT for joint pain/arthritis caused by aromatase inhibitors as a means to keep patients on therapy?

Using arthritis regimens such as 0.5 Gy x 6 fractions

2 Answers available

How do you approach prescribing analgesics for osteoarthritis related pain in patients with comorbidities, particularly given new evidence that even acetaminophen is associated with increased risk of GI complications (bleeding, peptic ulcer disease), heart failure and CKD?

2 Answers available

Do you offer low-dose radiation therapy for osteoarthritis of the spine?

3 Answers available

Is there any benefit to the use of low dose radiation in patients with osteoarthritis who have already undergone joint replacement?

1 Answer available

Would you try combination ketorolac and cortisone injections in a patient with severe knee OA who refuses surgery and had partial responses to injections of cortisone and ketorolac separately?

2 Answers available

Do you avoid hyaluronic acid injections in patients with chondrocalcinosis on imaging?

2 Answers available

What is your approach to progressive calvarial hyperostosis found in an elderly adult not caused by Pagets, acromegaly or hypercalcemia?

No evidence for acromegaly or Pagets.

1 Answer available

What is your approach to work up for patients referred for early onset osteoarthritis?

1 Answer available

Do you offer LDRT for psoriatic arthritis, rheumatoid arthritis, or polymyalgia rheumatica or fibromyalgia?

2 Answers available

Do you restrict topical diclofenac use in your patients with chronic kidney disease?

3 Answers available

Do you always aspirate effusions in patients with knee osteoarthritis prior to injecting hyaluronic acid?

2 Answers available

How do you counsel patients on the benefits of diet and exercise in OA in a way that motivates them to comply?

This question is part of a collaboration with RheumMadness and is specifically in reference to: Exercise in Knee OA

1 Answer available

Can joint replacement surgery be performed in someone with active Paget’s disease elsewhere?

1 Answer available

How do you decide when to try stopping hydroxychloroquine in patients with erosive osteoarthritis?

1 Answer available

Do you find MRI helpful to differentiate early erosive OA from psoriatic arthritis when early X-ray changes in both conditions may be hard to distinguish?

1 Answer available

Do you combine oral and topical NSAIDs for pain relief?

2 Answers available

What is your approach to refractory erosive osteoarthritis?

Significant impact on ADLs and no response to doxycycline, hydroxychloroquine, sulfasalazine or methotrexate.

2 Answers available

Do you utilize ethyl chloride spray prior to steroid injections?

1 Answer available

Despite the lack of evidence, do you utilize glucosamine and chondroitin sulfate for osteoarthritis?

2 Answers available

What is your experience with using extended release intra-articular steroid preparations, such as Zilretta in patients with osteoarthritis?

2 Answers available

How do you approach NSAID use in patients on SSRIs?

Do you avoid due to the increased risk of GI adverse events?

1 Answer available

In what situations do you consider platelet-rich plasma injections in patients with osteoarthritis?

1 Answer available

Are there any new treatments for erosive osteoarthritis of the hands?

1 Answer available

How do you counsel patients who ask you about trying oral or topical formulations of medical marijuana for pain related to arthritis or fibromyalgia?

1 Answer available

In patients with knee osteoarthritis, do you recommend the use of hyaluronate injections if it is available and affordable for the patient?

1 Answer available

Papers discussed in this category

Pain, 2020 May 18

Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials.

J. Rheumatol., 2019 Jan 15

Position Statement: A Pragmatic Approach for Medical Cannabis and Patients with Rheumatic Diseases.

Osteoarthritis Cartilage, 2018 Mar 02

A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial.

Ann Rheum Dis, 2018 Oct 03

Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial.

Ann Rheum Dis, 2018 Dec 14

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis.

Lancet, 2019 Nov 11

Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial.

The Journal of bone and joint surgery. American volume, 2018-04-18

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study.

Advances in therapy, 2019-06

Efficacy of Triamcinolone Acetonide Extended-Release in Participants with Unilateral Knee Osteoarthritis: A Post Hoc Analysis.

Osteoarthritis Cartilage, 2017 Oct 09

Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA).

J Bone Joint Surg Am,

An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee: a randomized clinical trial.

The New England journal of medicine, 2006-02-23

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.

Arthritis and rheumatism, 2008-10

The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial.

Rheumatic diseases clinics of North America, 2011-02

Glucosamine and chondroitin sulfate.

Ann Rheum Dis, 2014 Jan 06

Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens.

Int J Radiat Oncol Biol Phys, 2022 Apr 30

The Use of Low-Dose Radiotherapy in Osteoarthritis: A Review.

Rheumatology (Oxford), 2014 Sep 16

Differentiation between osteoarthritis and psoriatic arthritis: implications for pathogenesis and treatment in the biologic therapy era.

RMD open, 2021 Jul

Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands: results of the OA-TREAT study-a randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial.

Osteoarthritis and cartilage open, 2023 Feb 06

Genicular artery embolization for treatment of knee osteoarthritis pain: Systematic review and meta-analysis.

Annals of the rheumatic diseases, 2001 May

Acute arthritis after intra-articular hyaluronate injection: onset of effusions without crystal.

Life (Basel, Switzerland), 2023 Jul 28

Obesity-Related Knee Osteoarthritis-Current Concepts.

The New England journal of medicine, 2024 Oct 31

Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2014 Sep 20

DEGRO guidelines for the radiotherapy of non-malignant disorders. Part II: Painful degenerative skeletal disorders.

Strahlenther Onkol, 2021 Oct

Low-dose radiotherapy for painful osteoarthritis of the elderly: A multicenter analysis of 970 patients with 1185 treated sites.

Arthritis care & research, 2024 Dec 25

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink.

Ann Rheum Dis, 2019 Jan

Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: a randomised, double-blinded, sham-controlled trial.

Osteoarthritis and cartilage, 2018 Jul 07

Lack of beneficial effects of low-dose radiation therapy on hand osteoarthritis symptoms and inflammation: a randomised, blinded, sham-controlled trial.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2021 Nov 01

ArthroRad trial: multicentric prospective and randomized single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis depending on the dose-results after 3 months' follow-up.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2023 Oct 10

ArthroRad trial: randomized multicenter single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis-final results after 12-month follow-up.

Frontiers in immunology, 2022 Jan 03

Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients.

The British journal of radiology, 2015 May 08

Radiotherapy for non-malignant disorders: state of the art and update of the evidence-based practice guidelines.

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