General Primary Care

This question is part of our collaboration with ACR Convergence 2025 to preview a session from this year's meeting. This question is inspired by the u...

2 Answers available

What is your approach when counseling patients interested in bio-identical hormones for management of menopause versus traditional hormone replacement therapy?

1 Answer available

What is your approach when a female patient does not want a male MA/scribe present in the exam room but other staff are unavailable?

1 Answer available

What is your medication of choice when considering outpatient alcohol withdrawal management (diazepam vs chlordiazepoxide vs lorazepam)?

For your recommended medication, are you doing a scheduled set dose, or is it primarily symptom-driven?

4 Answers available

When would you consider prescribing a wakefulness promoting agent for excessive daytime sleepiness from insufficient sleep?

I.e. no sleep disorder diagnosis, unsuccessful behavioral interventions for improved sleep

3 Answers available

How would you treat a patient with osteoarthritis of just one joint of the hand?

Would you just treat the affected joint of the entire L hand? In case of treating just the affected joint, please explain your contouring and mobiliza...

2 Answers available

In patients on long-term proton pump inhibitors for GERD with stable symptoms, do you routinely attempt discontinuation or continue indefinitely given relapse risk?

If you trial discontinuation, what is your approach to tapering?

3 Answers available

What are your preferred second-line medications for trigeminal neuralgia?

In light of the publication by Muñoz-Vendrell et al., PMID 40341553.Related Q&A on onabotulinum toxin and trigeminal neuralgia.

3 Answers available

What is your approach to initiation of mirtazapine for appetite stimulation and depression in older adults, both in terms of starting dose and titration?

2 Answers available

At what eGFR do you typically refer for vein mapping for a patient with advanced CKD who prefers hemodialysis when indicated?

2 Answers available

In middle-aged adults with TSH 5–10 mIU/L and no symptoms, would you start levothyroxine or monitor, and does your threshold change with cardiovascular risk factors?

1 Answer available

Do you perform pap smears as part of the surveillance of patients with a history of cervical or vaginal cancers who had radiation as part of their treatment?

1 Answer available

How do you determine when ongoing outpatient treatment is no longer beneficial, and it may be appropriate to transition a patient to another provider?

2 Answers available

How would you manage a patient who presents with hair loss that began after they started a GLP-1 inhibitor?

1 Answer available

How do you manage anticoagulation/antiplatelet therapies with strong indications for uninterrupted therapy in setting of urgent procedures?

For example, anticoagulation for recent, significant PE or dual antiplatelet therapy for recent MI, but requiring urgent procedures such as biopsy of ...

4 Answers available

Would you biopsy calcified lung nodules and or lymphadenopathy that have shown stability over a 2-year period, in a bid to rule out sarcoidosis?

1 Answer available

How do you counsel patients with metabolic syndrome who decline statin therapy and have low coronary calcium scores regarding their long-term CVD risk?

3 Answers available

What is your approach to the use of GLP-1 agonists in older adults with diabetes with or at risk of sarcopenia?

3 Answers available

How many days prior to surgery do you recommend stopping SGLT2 inhibitors and when is it safe to resume therapy?

2 Answers available

What is your approach to the management of unprovoked distal DVTs?

Given the unprovoked nature, do you favor indefinite anticoagulation? Would a presentation with bilateral distal DVTs or other concerns for thrombophi...

1 Answer available

What is your general approach to an immunocompetent patient with chronic, non-infectious diarrhea?

1 Answer available

Would you recommend a GLP-1 agonist as an option to reduce the risk of dementia in patients with a strong family history?

Seminer et al., PMID 40193122

1 Answer available

Do you counsel patients to take antihypertensives at specific times of day to maximize efficacy or minimize side effects?

2 Answers available

For patients over 70 with elevated ASCVD risk but no prior cardiovascular events, do you ever recommend continuing or initiating low-dose aspirin?

Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication

1 Answer available

What is your systolic blood pressure target for patients over 80 with frailty and multiple comorbidities?

1 Answer available

Do you recommend that your patients with COPD avoid gabapentin or pregabalin entirely, given the increased rate of exacerbations noted in patients on these medications?

Rahman et al., PMID 38224592

1 Answer available

When discontinuing Denosumab after more than 2-3 years of therapy, when do you recommend giving the first dose of zoledronic acid?

3 Answers available

How effective have you found acupuncture for treatment of chronic migraine?

3 Answers available

Do you routinely use cefdinir for the treatment of common infections diagnosed in the outpatient setting such as CAP, uncomplicated UTIs?

1 Answer available

How do you counsel patients on the risks and benefits of antidepressant use during pregnancy?

How do you approach shared decision-making when patients express hesitancy about medication exposure in utero? What is your approach when a patient is...

3 Answers available

Would you pursue a colonoscopy for a patient in their 20s with constipation and rectal bleeding if they had a first-degree relative who died young from a "carcinoid tumor"?

How do you risk-stratify this otherwise low-risk young patient given the lack of specific guidelines for this rare cancer? Additionally, at what point...

1 Answer available

Do you have to extend treatment for acute Lyme disease if a patient is on high dose steroids for another indication?

2 Answers available

How can I incorporate neuromuscular ultrasound into my practice with limited prior experience?

1 Answer available

How can we approach tapering or discontinuing biologic DMARDs in patient in their 80s with well controlled rheumatoid arthritis?

3 Answers available

What recommendations do you provide to patients on isotretinoin about timing of tattoos?

1 Answer available

How do you determine whether to limit volume removal during therapeutic paracentesis in a patient without acute or chronic kidney disease?

3 Answers available

What is your approach to iron supplementation in patients with an active infection?

Are there situations in which you still feel comfortable giving IV iron? If not, do you consider PO iron?

1 Answer available

What is your preferred first-line treatment for chronic fatigue in patients with long COVID-19?

9 Answers available

How soon after a fracture would it be safe to start anti-resorptive therapy?

2 Answers available

What are your thoughts on the results of the ALONE-AF trial and the safety profile of discontinuing anticoagulation post-ablation, provided there is no atrial arrhythmia recurrence?

If it's reasonable to stop anticoagulation, how frequently should patients be monitored for AFib/atrial arrhythmia recurrence?

1 Answer available

Have any studies shown that testosterone replacement therapy lowers the incidence of prostate cancer in hypogonadal men, or is the evidence still largely neutral?

1 Answer available

How do you use NT-proBNP in patients with chronic kidney disease or end-stage kidney disease, given that these conditions can affect NT-proBNP levels?

1 Answer available

Would you use oral cefixime as an alternative treatment for early syphilis in cases of benzathine penicillin G shortages?

Klementova et al., PMID 40795115

1 Answer available

How do you manage patients who develop SIADH secondary to an SSRI but have had a strong positive response to that same medication?

What monitoring strategies (e.g., sodium checks, fluid restriction, dose adjustments) have you found most practical in these cases? In what situations...

1 Answer available

What is your antipsychotic of choice and general titration regimen in the outpatient setting for a patient with dementia and behavioral disturbances (assuming reversible causes such as urinary retention, constipation, etc. have been addressed)?

2 Answers available

Do you have a preference between an ACEI and ARB when initiating therapy for a patient with diabetic kidney disease, albuminuria, and hypertension?

7 Answers available

Should we be recommending a specific daily protein intake to prevent sarcopenia in geriatric patients, or do you find it more beneficial to focus on encouraging activity within their mobility limitations to preserve muscle mass?

1 Answer available

How do you approach balancing the treatment of urinary incontinence with anticholinergic medications with the use of cholinesterase inhibitors in dementia?

1 Answer available

How do you counsel older adults regarding the use, dosing, and safety of CBD-containing products for insomnia?

1 Answer available

How do you counsel patients with depression about the role exercise may play in alleviating depressive symptoms?

How do you educate patients about the role exercise may play in depression treatment? What type, frequency, and intensity of exercise do you recommend...

2 Answers available

Is there a role for functional medicine approaches in psychiatric treatment?

How do you critically assess the evidence base for functional medicine approaches? How do you respond when patients specifically request functional me...

1 Answer available

Outside of their use in performance anxiety, have you tried or found benefit with a daily beta blocker for generalized anxiety?

Especially if a patient is intolerant to SSRI/SNRI, TCA, etc.

1 Answer available

How do you approach the timing of skin tightening interventions in patients who experience significant weight loss to optimize both intermediate and long-term aesthetic outcomes?

2 Answers available

Do you routinely adjust your interpretation of SLUMS and/or MOCA tests in patients depending on their level of education?

1 Answer available

Do you start bisphosphonates after tapering off menopausal hormone therapy to prevent the rapid decline of bone mineral density?

1 Answer available

How would you counsel a woman with a strong family history of thrombosis about oral contraceptives?

Would you recommend avoiding estrogen-containing OCPs? Would you test for APLS to evaluate for additional thrombotic risk factors? While not heredita...

2 Answers available

What additional workup would you perform to evaluate a new onset of spontaneous hemarthrosis?

Young adult male previously without bleeding diathesis and no family history. Platelet count, PT, and PTT are normal. Also normal factor 8, 9, 12, 7, ...

1 Answer available

How do you manage anxious children who are somatically focused and do not tolerate SSRIs?

6 Answers available

Can tamoxifen be safely prescribed for breast cancer patients with cirrhosis?

4 Answers available

How do you address social determinants of health that impact patients (e.g., housing instability, food insecurity) but for which there are no immediate resources available?

1 Answer available

When do you recommend limited or targeted respiratory pathogen testing versus a full respiratory pathogen panel in a patient presenting with URI symptoms?

In other words, are there benefits to identifying URI pathogens that do not necessarily have targeted therapies (e.g., rhinovirus, non-COVID-19 Corona...

3 Answers available

Do you routinely recommend transition to dual PO antibiotic coverage for strep species and MRSA, for patients with purulent cellulitis and in the absence of culture data?

2 Answers available

What strategies do you use for patients on medications for ADHD who experience afternoon rebound/withdrawal?

5 Answers available

What factors influence your decision to start salt tablets, urea, or a vaptan first in the management of a patient diagnosed with SIADH?

3 Answers available

What suggestions for environmental modifications do you find most helpful to reduce the risk of falls in the geriatric population?

Are there certain modifications to the home or aid devices that you commonly recommend? Some that are more cost-effective?

1 Answer available

Do you recommend initiating treatment with an SGLT2 inhibitor or semaglutide first for a patient with obesity and heart failure with preserved ejection fraction?

Would you initiate both medications at the same time?

1 Answer available

What is your go-to strategy for non-opioid management of chronic low back pain in patients with limited access to physical therapy or behavioral health?

1 Answer available

How do you approach balancing the risks and benefits of elective surgery with patients who have multiple co-morbidities (e.g., frailty, chronic kidney disease, and COPD), when standard risk calculators do not capture the full complexity of their condition?

2 Answers available

Do you have safety concerns when prescribing GLP-1 medications in patients on corticosteroids or immunosuppressive therapy?

This question is part of our collaboration with ACR Convergence 2025 to preview a session from this year's meeting. This question is inspired by the u...

1 Answer available

How do you consider sending fungal studies in a patient with pneumonia?

When do you have consider sending them as part of your initial workup?

2 Answers available

Do you consider using buspirone for the management of anxiety in older patients?

4 Answers available

How do you weigh the risks and benefits of GLP-1 RAs in patients over age 65 specifically in regards to loss of muscle mass and osteoporosis?

How do you counsel patients about these risks? This question is part of our collaboration with ACR Convergence 2025 to preview a session from this ye...

1 Answer available

What is your approach to a positive PPD or IGRA in a patient with well-controlled HIV without significant TB risk factors?

5 Answers available

How do you decide between anticoagulation and observation for an incidentally detected subsegmental pulmonary embolism in elderly patients with a history of gastrointestinal bleeding?

7 Answers available

How has the use of CGMs informed or improved your management of patients with pre diabetes or diabetes not on insulin?

2 Answers available

With the difficulty in access to PPSV23 as the new pneumonia vaccine is now standard (non polysaccharide vaccine), have you used MPSV4 (meningococcal) vaccine for evaluation of response to polysaccharide vaccine?

Have you used this for adults, children, or both?

1 Answer available

Do you have any concerns about lower extremity compression (e.g., compression stockings, intermittent pneumatic compression, etc.) worsening ascites in a patient with portal hypertension?

1 Answer available

What is your approach to preventing exercise-associated hyponatremia?

3 Answers available

How do you approach the treatment of patients with Ehlers-Danlos hypermobile type with chronic muscle spasms with minimal exertion?

2 Answers available

How many days prior to elective major surgery do you recommend holding oral GLP 1 R agonist therapy?

4 Answers available

What is your next step in management for patients who develop sexual side effects on an SSRI (anorgasmia, low libido, etc.) but are responding well to therapy?

Related Mednet discussion on low libido and SSRIs

3 Answers available

Do you recommend fluid restriction in addition to other management strategies for patients with hyponatremia due to SIADH?

6 Answers available

What strategies do you recommend for discussing the use of OCP in women with a history of migraines with or without aura?

1 Answer available

What therapies do you recommend for patients with limited life expectancy (<3 months) but whose depression is significantly reducing their quality of life?

2 Answers available

How do you integrate HIV (+) serostatus into a patient's ASCVD if they would not otherwise qualify for a statin either for primary or secondary prophylaxis?

1 Answer available

Should presence of coronary artery calcifications on CT/CTA be considered as presence of vascular disease on CHA2DS2-VASc score?

2 Answers available

Would you consider the use of romosozumab in men who have failed therapy with teriparatide and sustained multiple vertebral fractures?

Romosozumab is not currently FDA approved for men.

1 Answer available

How do you define treatment-resistant depression in your practice?

What strategies do you use to counsel patients on continuing an antidepressant until therapeutic doses versus switching agents if they perceive a lack...

1 Answer available

How do you discuss the role (if there is any) of frequently weighing yourself at home for patients who desire weight loss?

Is there a role, or do you find it largely drives the fixation of health being based on the number on the scale?

3 Answers available

Do you routinely prescribe vitamin D to reduce the risk of fall-related fractures in elderly patients regardless of their serum levels?

1 Answer available

When stopping denosumab and transitioning to PO bisphosphonate, do you wait for 6 months after the last denosumab injection to start PO bisphosphonate?

2 Answers available

What is the next best osteoporosis treatment option for patients who completed 2 years of teriparatide, but has contraindication to bisphosphosnate therapy (e.g. history of atypical femur fracture)?

1 Answer available

What is your strategy for counseling patients who don't qualify for colorectal cancer (CRC) screening under the current guidelines but are concerned with its increasing incidence at a younger age?

USPSTF Colorectal Cancer: Screening Recommendation

1 Answer available

How would you approach hormone replacement therapy for perimenopause in a patient with increased risk factors for VTE (hereditary thrombophilia without personal thrombosis, family history of thrombophilia or thrombosis, etc.)?

1 Answer available

How do you reconcile the risk of contrast-induced nephropathy (CIN) with the diagnostic benefit of contrasted CT in patients with AKI/CKD?

Does your approach change with venous vs arterial contrast?

1 Answer available

Do you consider co-prescribing hormone therapy and anticoagulation in a patient with prior DVT and uncontrollable VSM uncontrolled by non-hormonal therapies?

4 Answers available

What is your approach to patients who insist on testosterone replacement therapy despite normal testosterone levels on repeated labs?

Prompted by nonspecific symptoms that could be related to low testosterone or many other conditions (i.e., fatigue, poor sleep) especially with all th...

1 Answer available

What is your approach to a situation where DILI is suspected secondary to an important medication (e.g., anticoagulation, antibiotics, etc.), but the diagnosis is uncertain and the liver injury is relatively mild?

Are there situations in which you would continue the possible offending agent with close monitoring?

1 Answer available

Would you use a parathyroid hormone analog for treatment of osteoporosis in a patient with mildly elevated AlkPhos of unclear etiology?

1 Answer available

Do 5HT4 agonists such as Metoclopramide actually lead to improvement in symptoms for patients with diabetes related gastroparesis?

1 Answer available

Would you start romosozumab in an active smoker?

1 Answer available

During treatment of severe osteoporosis with PTH analogs (abaloparatide), would a rise in alkaline phosphatase level >200 (in the setting of normal GGT) warrant discontinuation of medication?

There is concern for elevation in alkaline phosphatase as a precursor for bone pathology, such as an increase in risk of bone malignancy, potentially ...

1 Answer available

What additional therapies can be helpful for vaginal dryness causing dyspareunia in premenopausal woman already using lubrication?

Any specific lubricant more effective than another?

2 Answers available

Do you provide empiric doxycycline for Lyme Disease to asymptomatic patients after a tick bite who haven't developed Erythema migrans or are not sure it was an Ixodes tick?

2 Answers available

How do you recommend counseling patients on the prognosis of advanced cancer as a generalist who is not highly specialized in cancer literature or cancer-directed therapies?

2 Answers available

What is your approach to isolated alkaline phosphatase without other laboratory abnormalities?

What are your next diagnostic steps/tests?

1 Answer available

What is your preferred laboratory test to assess treatment response or infection resolution in patients with bacterial pneumonia?

For example, do you find trending WBC, procalcitonin, CRP, etc., more or less helpful?

3 Answers available

Is there an age cutoff where you consider the risks of monoclonal antibody therapy outweigh any potential benefit(s) in early-onset dementia?

1 Answer available

Do you recommend treatment of male partners for patients with recurrent bacterial vaginosis?

Vodstrcil et al., PMID 40043236.

1 Answer available

Would you continue or stop anticoagulation for a DVT/PE in a patient with active cancer who has completed 6 months of therapy?

Mahé et al., PMID 40162636

2 Answers available

Is there a role for use of GLP-1/GIP receptor agonists in the management of substance use disorders, whether or not they meet other inclusion criteria for their use?

2 Answers available

Other than oxybutynin or mirabegron, what pharmacological and non-pharmacological treatments would you consider for increased urinary frequency (not caused by infection, medications, or resulting in incontinence)?

1 Answer available

Would you start an SGLT2 inhibitor in patients with diabetic kidney disease who also have a history of prior toe amputation?

4 Answers available

Do you recommend initiating an ACE inhibitor or ARB in a patient with proteinuric CKD Stage 5?

2 Answers available

How do you approach diagnosing ADHD in patients with significant trauma histories?

2 Answers available

What do you think about using conventional thoracic imaging methods (e.g., X-ray, CT, etc.) to determine if a pleural effusion is of adequate size to consider thoracentesis?

3 Answers available

When would you consider long-term cardiac monitoring to look for atrial fibrillation in patients with mitral stenosis given their baseline elevated risk for atrial fibrillation and thrombosis?

2 Answers available

How should we approach the recommendation of intermittent fasting for weight loss in patients with pre-existing cardiovascular conditions, given the observed association of increased CV mortality with eating durations of less than 8 hrs?

Chen & Zhong, AHA/ASA Journals 2024

2 Answers available

How do you consider and approach transition to hospice in a patient with HFrEF who does not appear to tolerate GDMT?

3 Answers available

What is your approach to duration of fidaxomicin in a patient receiving treatment for first C difficile infection while also receiving concurrent antibiotics for an infection?

Do you extend the course of fidaxomicin past initial 10 days to at least 3-7 days after completion of antibiotics?

1 Answer available

How do you counsel patients on GLP-1 agonists for weight loss who wish to space out their medication or take a "drug holiday" to temporarily increase their appetite?

For example, if someone has an upcoming vacation or family gathering, is it okay to temporarily stop their medication to increase their appetite?

1 Answer available

Do you routinely take a cancer history from patients being evaluated for atopy?

There is a longstanding debate about the association of atopy with cancer risk. Significant literature evidence (mostly epidemiological) supports the ...

1 Answer available

What adjunctive therapies beyond an antisecretory agent (e.g., PPI, H2RA, etc.) do you find most helpful in managing the acute symptoms of PUD?

For example, do you routinely supplement with calcium carbonate, magnesium hydroxide, aluminum hydroxide, simethicone, sucralfate, etc.?

1 Answer available

What do you think about chronic suppressive therapy for HSV-2 in a patient with positive antibodies but no prior clinical outbreak?

Would you expect the presence of antibodies to indicate either immunity from contracting the infection, or otherwise risk of transmitting a latent inf...

2 Answers available

How do you counsel non-diabetic patients who wish to start metformin to reduce the risk of developing dementia?

2 Answers available

How do you counsel patients who express concerns about receiving multiple vaccinations at once versus spacing them out over time?

1 Answer available

How do you decide whether average-risk patients should undergo annual or biennial breast cancer screening?

1 Answer available

How do you counsel someone about metformin use for type 2 diabetes mellitus who is also on a GLP-1 agonist and achieved goal HbA1c, but prefers not to be on metformin anymore?

1 Answer available

What are some practical ways to incorporate cardiac POCUS in the primary care setting?

For example, do you find it most useful for outpatient disease assessment/management, consideration of further imaging or specialist referral, or tria...

1 Answer available

How do you decide the maximum amount of volume to remove during a therapeutic thoracentesis?

Do you use the traditional strict limit of 1.5 L, or do you consider removing more volume if a patient appears to tolerate it?

1 Answer available

How do you decide whether to use lung POCUS versus CT as the next step when a chest X-ray is equivocal for pneumonia?

3 Answers available

What is your preferred screening tool for colon cancer in an average-risk patient?

1 Answer available

Do you recommend starting with oral or intramuscular B12 supplementation in patients with newly diagnosed deficiency?

1 Answer available

In patients with confirmed hypercortisolism with a high/normal unsuppressed ACTH who have both a pituitary adenoma and adrenal adenoma identified on imaging, can you reliably use DHEA-S to determine the source of cortisol production?

2 Answers available

What is your risk/benefit analysis when deciding on the appropriateness and timing for discontinuation of systemic anticoagulation in patients who underwent ablation for paroxysmal atrial fibrillation with CHADS2VASc score >2?

1 Answer available

Do you take any special considerations when working up a pregnant patient for secondary causes of hypertension?

1 Answer available

How do you counsel patients who ask if they should take a daily multivitamin?

1 Answer available

What is your approach to secondary prophylaxis for C difficile infection during concomitant antibiotic use in a patient with a history of C difficile infection?

1 Answer available

What is the preferred first-line non-insulin agent in patients with ketosis-prone diabetes during "remission" and evidence of preserved beta cell function?

2 Answers available

What factors would lead you to extend the duration of antithyroid drug therapy in a patient with Graves' disease who is clinically euthyroid at 12 months but has risk factors for recurrence?

3 Answers available

What duration of antibiotic therapy do you use for a loculated parapneumonic effusion that does not meet criteria for empyema?

6 Answers available

Do you recommend routinely monitoring pancreatic markers such as amylase and lipase while receiving GLP1 R agonist or dual agonist therapies to determine their risk of pancreatitis?

2 Answers available

Is there any role for administering another course of recombinant zoster vaccine (Shingrix) in a previously vaccinated patient with RA, who is in clinical remission on JAK inhibitor but has had a breakthrough shingles infection?

The last SHINGRIX was about 4 years ago and both doses were given.

2 Answers available

How do you approach the work-up for a patient with iron deficiency anemia who is not responding to oral iron therapy?

Presuming good medication adherence.

1 Answer available

Should we be more cautious with the use of GLP 1 R agonist therapy in patients with Type 1 diabetes mellitus and obesity given the increased risk of cardiovascular disease with high body weight variability?

Prattichizzo et al., PMID 39468384

1 Answer available

How do you approach the use of metformin in the management of prediabetes for patients who are neither obese nor have a family history of diabetes?

2 Answers available

When managing patients with suspected MASLD, what specific criteria or findings would prompt you to refer them to hepatology?

1 Answer available

Do you counsel a mother to avoid certain food in her diet if she is still breast feeding and her child has confirmed IgE mediated food allergies?

1 Answer available

Would you recommend starting an SGLT2 inhibitor in a proteinuric CKD patient with chronic asymptomatic bacteriuria?

2 Answers available

How do you approach the management of a patient with symptomatic iron deficiency anemia who is intolerant of iron?

Such as a patient who cannot tolerate oral iron and has had a anaphylaxis to intravenous iron

4 Answers available

Papers discussed in this category

Medical sciences (Basel, Switzerland), 2018-09-21

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization.

The Journal of clinical investigation, 2021 Dec 15

The intersection of COVID-19 and autoimmunity.

Molecular systems biology, 2023 Mar 15

A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation.

BMJ open, 2024 May 13

Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia.

Ann Intern Med, 2019 Jul 30

Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Severe Urinary Tract Infections: A Population-Based Cohort Study.

Microbes and infection, 2024 May 06

Secondary prophylaxis for Clostridioides difficile infection for patients on non-C. difficile antibiotics: a retrospective cohort study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2021 Feb 24

Provider recommendations and maternal practices when providing breast milk to children with immunoglobulin E-mediated food allergy.

Circulation research, 2020 Jun 18

Population-Based Screening for Atrial Fibrillation.

Journal of the American College of Cardiology, 2024 Aug 29

Effect of Screening for Undiagnosed Atrial Fibrillation on Stroke Prevention.

European journal of endocrinology, 2008 Jan

TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study.

The New England journal of medicine, 2023 Nov 11

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.

N Engl J Med,

Intrapleural use of tissue plasminogen activator and DNase in pleural infection.

The New England journal of medicine, 2022 Apr 21

Calorie Restriction with or without Time-Restricted Eating in Weight Loss.

The lancet. Healthy longevity, 2024 Apr 05

Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial.

Diabetes & metabolic syndrome, 2024 Feb 05

Does early time-restricted eating reduce body weight and preserve fat-free mass in adults? A systematic review and meta-analysis of randomized controlled trials.

Diabetes care, 2016-11

Randomized Controlled Study of Metformin and Sitagliptin on Long-term Normoglycemia Remission in African American Patients With Hyperglycemic Crises.

Endocrinology and metabolism clinics of North America, 2022 Nov 04

Remission in Ketosis-Prone Diabetes.

Journal of clinical lipidology, 2022 Sep 11

Assessment and management of statin-associated muscle symptoms (SAMS): A clinical perspective from the National Lipid Association.

Hepatology (Baltimore, Md.), 2012 Apr

Albumin infusion in patients undergoing large-volume paracentesis: a meta-analysis of randomized trials.

Lancet (London, England), 2015 Mar 12

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial.

Journal of palliative medicine, 2012-02

Systematic review of cancer presentations with a median survival of six months or less.

Journal of the American Medical Directors Association, 2022 Mar 23

Post-Acute Care Outcomes and Functional Status Changes of Adults with New Cancer Discharged to Skilled Nursing Facilities.

Palliative medicine, 2022 Jul

The utility of the surprise question: A useful tool for identifying patients nearing the last phase of life? A systematic review and meta-analysis.

JAMA, 2021 Apr 13

Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

Journal of the American Geriatrics Society, 2025 Jan 29

Updating STEADI for Primary Care: Recommendations From the American Geriatrics Society Workgroup.

Neuropsychopharmacology reports, 2025 Mar

A Report of Three Cases With Dissociative Disorder: Some Positive Response to Methylphenidate Extended Release Used for Their Concurrent Attention Deficit Hyperactivity Disorder.

N Engl J Med, 2021 Aug 27

Empagliflozin in Heart Failure with a Preserved Ejection Fraction.

JACC. Heart failure, 2022 Mar

Baseline Characteristics of Patients With HF With Mildly Reduced and Preserved Ejection Fraction: DELIVER Trial.

The New England journal of medicine, 2023 Aug 25

Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.

The New England journal of medicine, 2024 Nov 16

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.

Journal of the American College of Cardiology, 2023 Apr 19

2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee.

Drug and alcohol dependence, 2024 Sep 07

Potential role of glucagon-like peptide-1 (GLP-1) receptor agonists in substance use disorder: A systematic review of randomized trials.

JAMA psychiatry, 2025 Apr 01

Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial.

Journal of the American College of Radiology : JACR, 2024 Jun

ACR Appropriateness Criteria® Workup of Pleural Effusion or Pleural Disease.

AJR. American journal of roentgenology, 2010-02

Differentiation of pleural effusions from parenchymal opacities: accuracy of bedside chest radiography.

The New England journal of medicine, 2023 Aug 17

Community-Acquired Pneumonia.

Thorax, 2009 Oct

BTS guidelines for the management of community acquired pneumonia in adults: update 2009.

The American journal of medicine, 1991 Aug 08

Treatment of peptic ulcer disease with sucralfate: a review.

Gut, 1990 Jul

Sucralfate in the treatment and prevention of gastric ulcer: multicentre double blind placebo controlled study.

Heart failure reviews, 2021 Apr 09

Lung ultrasound-guided management to reduce hospitalization in chronic heart failure: a systematic review and meta-analysis.

International journal of cardiology, 2017 Aug 01

Pulmonary congestion evaluated by lung ultrasound predicts decompensation in heart failure outpatients.

Cardiovascular ultrasound, 2006 Aug 31

Evaluation of ultrasound lung comets by hand-held echocardiography.

The journals of gerontology. Series A, Biological sciences and medical sciences, 2023 Jun 16

Nutritional Interventions: Dietary Protein Needs and Influences on Skeletal Muscle of Older Adults.

Mayo Clinic proceedings, 2000 Jan

The biology of aging.

Journal of the American Geriatrics Society, 2000 Jun

Epidemiology of sarcopenia.

Kidney international. Supplement, 2002 Dec

Comparative effects of ACE inhibition and angiotensin II receptor blockade in the prevention of renal damage.

JAMA internal medicine, 2014 May

Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis.

Journal of addiction medicine, 2020 May/Jun

The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management.

Alcohol (Fayetteville, N.Y.), 2014-06

The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome.

American journal of preventive medicine, 2015-10

Emergency Department Visits and Overdose Deaths From Combined Use of Opioids and Benzodiazepines.

Cureus, 2023 Jun 07

Play Therapy As Effective Options for School-Age Children With Emotional and Behavioral Problems: A Case Series.

JACC. Heart failure, 2024 Aug 31

Natriuretic Peptides, Kidney Function, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.

The New England journal of medicine, 2025 Mar 29

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism.

The New England journal of medicine, 2025 Mar 06

Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis.

The New England journal of medicine, 2013-01-17

Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient.

Expert opinion on drug safety, 2016 Jan 25

Revisiting doxycycline in pregnancy and early childhood--time to rebuild its reputation?

The Journal of clinical endocrinology and metabolism, 2022 Dec 17

Inpatient Zoledronic Acid and Integrated Orthopedic and Fracture Liaison Services Improve Osteoporosis Treatment Rates.

J Bone Miner Res, 2024 Aug 21

Zoledronic acid for hip fracture during initial hospitalization.

J Clin Endocrinol Metab, 2023 Oct 18

Safety of Inpatient Zoledronic Acid in the Immediate Postfracture Setting.

Blood, 2015 Dec 22

Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use.

Menopause (New York, N.Y.), 2024 Feb 01

Does hormone therapy exacerbate other venous thromboembolism risk factors?

Research and practice in thrombosis and haemostasis, 2023 Apr 24

Hormonal therapies in females with blood disorders: thrombophilia, thrombosis, hemoglobinopathies, and anemias.

Blood advances, 2024 Jul 09

Decision theoretical foundations of clinical practice guidelines: an extension of the ASH thrombophilia guidelines.

Blood advances, 2023 Nov 28

American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing.

BMC medical informatics and decision making, 2010 Sep 16

A regret theory approach to decision curve analysis: a novel method for eliciting decision makers' preferences and decision-making.

Arthritis Rheumatol, 2021 Jul

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.

Rheumatology (Oxford, England), 2023 Oct 19

A real-world 2-year prospective study of medication tapering in patients with well-controlled rheumatoid arthritis within the rheumatoid arthritis medication tapering (RHEUMTAP) cohort.

Arthritis research & therapy, 2015 Aug 03

Sustained biologic-free and drug-free remission in rheumatoid arthritis, where are we now?

Arthritis and rheumatism, 2009 Aug

Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohorts.

Journal of pain and symptom management, 2002-05

An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.

The Cochrane database of systematic reviews, 2006-07-19

Azapirones for generalized anxiety disorder.

Psychiatry and clinical neurosciences, 2010 Feb 01

Randomized, single-blind, trial of sertraline and buspirone for treatment of elderly patients with generalized anxiety disorder.

Basic & clinical pharmacology & toxicology, 2023 Jun 20

Serotonin syndrome-A focused review.

Ochsner journal, 2013 Winter

Serotonin syndrome.

Diabetes research and clinical practice, 2021 Mar 08

GLP-1 receptor agonists and SGLT2 inhibitors for older people with type 2 diabetes: A systematic review and meta-analysis.

Journal of diabetes, 2025 Jun

Monitoring Sarcopenia With Incretin Receptor Activator Treatment.

Annals of internal medicine, 2021 Nov 23

Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation : A Multicenter Prospective Cohort Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2025 Mar 09

Denosumab discontinuation in the clinic: implications of rebound bone turnover and emerging strategies to prevent bone loss and fractures.

Cureus, 2023 Oct 16

Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.

American journal of hematology, 2024 Jan 29

Expert consensus guidelines: Intravenous iron uses, formulations, administration, and management of reactions.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2024 Jun 12

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.

American family physician, 2022 Sep

Risk of Infection With Intravenous Iron Infusion.

Journal of the American College of Cardiology, 2024 Jun 25

Intravenous Iron Repletion for Patients With Heart Failure and Iron Deficiency: JACC State-of-the-Art Review.

Am J Respir Crit Care Med, 2019 Sep 1

Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline.

Chest, 2023 Oct 07

A Diagnostic Approach to Fungal Pneumonia: An Infectious Diseases Perspective.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024 Mar 05

Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM).

AIDS (London, England), 2025 May 23

Risks for sudden cardiac and undetermined cause of death among people with HIV in the REPRIEVE primary cardiovascular prevention trial.

JAMA, 2011-09-28

Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis.

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 2024 Aug 08

U.S. Medical Eligibility Criteria for Contraceptive Use, 2024.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2024 Oct 29

Multisociety clinical practice guidance for the safe use of glucagon-like peptide-1 receptor agonists in the perioperative period.

The Journal of antimicrobial chemotherapy, 2025 Aug 07

Cefixime versus benzathine penicillin G for the treatment of early syphilis-a randomized, controlled open label trial.

Nature reviews. Urology, 2022 Dec 21

The testosterone paradox of advanced prostate cancer: mechanistic insights and clinical implications.

Drugs & aging, 2001

Hypertension in the Very Elderly Trial (HYVET): protocol for the main trial.

Circulation research, 2019 Mar 29

Hypertension Management in Older and Frail Older Patients.

Frontiers in neuroscience, 2023 Sep 08

The durable effect of acupuncture for episodic migraine: a systematic review and meta-analysis.

Journal of neurology, 2020 Aug 24

Efficacy of acupuncture for migraine prophylaxis: a trial sequential meta-analysis.

JAMA, 2020 Nov 03

Diagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review.

BMJ (Clinical research ed.), 2022 Nov 23

Rivaroxaban treatment for six weeks versus three months in patients with symptomatic isolated distal deep vein thrombosis: randomised controlled trial.

Circulation, 2023 Nov 30

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

JAMA, 2025 Oct 14

Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation: The ALONE-AF Randomized Clinical Trial.

PloS one, 2021 Jun 24

Discontinuation of oral anticoagulation therapy after successful atrial fibrillation ablation: A systematic review and meta-analysis of prospective studies.

The New England journal of medicine, 1985-04-04

Successful parenteral penicillin therapy of established Lyme arthritis.

The Laryngoscope, 2017-06

Steroid use in Lyme disease-associated facial palsy is associated with worse long-term outcomes.

Arthritis & rheumatology (Hoboken, N.J.), 2020 Nov 29

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease.

Muscle & nerve, 2012-08

Evidence-based guideline: neuromuscular ultrasound for the diagnosis of carpal tunnel syndrome.

Muscle Nerve, 2024 Mar

Neuromuscular ultrasound: Impact on diagnosis and management.

Muscle & nerve, 2018 Sep 11

Neuromuscular ultrasound in electrically non-localizable ulnar neuropathy.

Neurology, 2014 Aug 27

Sensitivity and specificity of diagnostic ultrasound in the diagnosis of phrenic neuropathy.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016 Jun 14

The field size matters: low dose external beam radiotherapy for thumb carpometacarpal osteoarthritis : Importance of field size.

Journal of addiction medicine, 2021 May-Jun 01

Using Extended Release Buprenorphine Injection to Discontinue Sublingual Buprenorphine: A Case Series.

General Primary Care

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