Hematology

Myeloproliferative Neoplasms   

Questions discussed in this category


Would you get bone marrow biopsy periodically? Would your approach change based off specific age or platelet count?  

Do you recommend therapeutic phlebotomy to a certain Hct goal? Any strong evidence for thromboembolic risk related to erythrocytosis or if this is mit...

Aside from addressing the underlying case, is there a role for phlebotomy in secondary polycythemia such as in COPD or post-renal transplant erythrocy...

For example, a patient on cytoreductive therapy and aspirin BID, but suffers an arterial event, or a patient who is already on therapeutic anticoagula...

This is in the setting of a patient who is now on ruxolitinib with rising leukocytosis and thrombocytosis, but cannot be on aspirin due to recent blee...

Individuals with MPNs may be at higher risk for thrombosis and be placed on antiplatelet therapy or even anticoagulation because of prior thrombosis. ...

In patients who are intolerant to hydroxyurea, anagrelide and interferon

In a patient with no evidence of bleeding, do you use a platelet cutoff? Do you utilize genomic testing (eg CALR, MPL, JAK2, etc.) to decide on cytore...


Papers discussed in this category


Chest, 1975-12

Clin Nephrol,

Eur J Intern Med, 2016 Dec 02

Ann Hematol, 2017 Nov 21

Blood Cancer J, 2018 Feb 09

Blood, 2017 May 08