Medical Oncology

Neuroendocrine Tumors   

Questions discussed in this category

Does DOTATATE scan results/burden of disease change your preference?

Would a negative dotatate PET change management for a patient for whom you were planning to start SSAs?

Do you drop or adjust the temozolomide at any point, or rather continue to progression as long as temozolomide is well tolerated?

Which patients would you recommend active surveillance alone, a less morbid procedure such as enucleation, or a Whipple surgery? How does age influenc...

Pathology details: 75% high grade large cell neuroendocrine tumor of the cecum (20-30 mitoses per 10 hpf, Ki67 75%) and 25% adenocarcinoma. Patient ha...

Would there be any benefit to surgery in a healthy/good PS patient? There is so little data on pulmonary atypical carcinoid and radiation respons...

Would you use a small cell regimen over a more traditional FOLFOX-esque approach?

Is there a distinction between these tumors and patients with breast cancer with neuroendocrine features?

Does the advent of more effective therapies like peptide receptor radioligand therapy (PRRT) and capecitabine and temozolomide (CAPTEM) dampen enthusi...

Would you treat with typical small cell paradigms such as surgery followed by adjuvant platinum doublet +/- radiation vs definitive chemoradiation? Or...

Would the presence of peritoneal carcinomatosis change your treatment strategy? If Ki-67 <50%, would you avoid platinum based cytotoxics?

Would you consider first line treatment with somatostatin analog or Lu 177 dotatate? Is observation an option for asymptomatic patients?

Given the variable and sometimes indolent disease course of these patients, as well as the absence of a clear overall survival benefit in the PROMID&n...

There is some data on TMZ and 5FU based regimens, but convincing evidence is lacking. How would you approach this situation?

Papers discussed in this category

Curr Oncol, 2020 Dec 01

Lancet Oncol, 2020 Feb 26

J Clin Oncol, 2009 Oct 1

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019-09

N Engl J Med,

Pancreas, 2013-07

Eur J Radiol, 2006 Feb 21

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-03-01

Eur. J. Nucl. Med. Mol. Imaging, 2016 Aug 18

Pancreas, 2016-11


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-05-20

Br J Surg,

American journal of clinical oncology, 1997-06

The Annals of thoracic surgery, 2015-02

Thorac Cardiovasc Surg,

JAMA network open, 2020 Nov 02

Journal of gastrointestinal cancer, 2015-06

Eur. J. Cancer, 2017 May 11

Curr Treat Options Oncol, 2019 Aug 19

J Oncol, 2019 Feb 20

Endokrynol Pol, 2019 Mar 07

The New England journal of medicine, 2017-01-12

Clin. Cancer Res., 2018 Jun 27

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005-01

J. Nucl. Med.,

Neuroendocrinology, 2017 Apr 13

J Natl Compr Canc Netw,

Endocr. Relat. Cancer, 2017 Oct 24

The New England journal of medicine, 2018-12-06

Lancet, 2019 Oct 04


Front Endocrinol (Lausanne), 2020 Apr 29

Case Rep Pathol, 2016 Oct 20

Breast Care (Basel),

Clinical nuclear medicine, 2015-11

Surgery, 2016-01

J Nucl Med, 2012 Sep 17

Cardiovasc Intervent Radiol, 2019 Oct 23

Eur J Nucl Med Mol Imaging, 2018 Sep 28

Seminars in oncology, 2018-08

Endocrine-related cancer, 2016-09

Pancreas, 2017-07

JAMA Oncol, 2020 Apr 16

Pancreas, 2020 Jan

Surg Oncol Clin N Am, 2020 Oct 20

Scand J Gastroenterol, 2019 Aug 01

J Am Coll Surg, 2017 Jan 11

J Clin Oncol, 2018 Jun 07

Archives of surgery (Chicago, Ill. : 1960), 2008-07

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018-01

Ann Surg,

Am J Transplant, 2016 Jun 09

Transplantation, 2021 Apr 27

Surgery, 2017 Jun 16

The New England journal of medicine, 2009-01-08

Am J Surg, 2020 Aug 16

Eur J Endocrinol, 2013 Apr 15

Jpn J Clin Oncol, 2013 Dec 22


J Clin Endocrinol Metab,

J Endocrinol Invest, 2018 Jun 09

Br J Radiol, 2018 Mar 20

Eur J Nucl Med Mol Imaging, 2013 Sep 13

BMC Cancer, 2019 Aug 08

Scand J Gastroenterol, 2021 Jan 20

Int J Endocrinol, 2021 Jan 23

Cancer Treat Rev, 2020 Dec 22

Human pathology, 2016-03

Seminars in oncology, 2018-08

Pancreas, 2020 Aug

Neuroendocrinology, 2021 Feb 02

Ann. Surg., 2019 Aug 30

Annals of surgical oncology, 2019-04

Eur Respir J, 2017 Oct 12

J Natl Compr Canc Netw, 2021 Aug 24

J Neuroendocrinol, 2022 Apr 05

Neuroendocrinology, 2019 Sep 17


Endocrine-related cancer, 2015-06

Cancer, 2018-02-15

Clin Cancer Res, 2020 Sep 1

Clin Cancer Res, 2020 Jan 22

Eur J Cancer, 2013 Jan 23

Ann Oncol, 2012 Sep 11

Endocr Relat Cancer, 2012 Nov 06

J Cancer, 2014 Aug 01

Clin Cancer Res, 2019 Oct 31

Oncologist, 2021 Aug 21

Endocr Connect,

ESMO Open, 2021 Apr 23

Oncologist, 2020 Sep 17

Br J Cancer, 2020 Mar 10

Chest, 2020 Aug 14

Chest, 2020 Jul

ERJ Open Res, 2020 Oct

Human pathology, 2018-09

Pancreas, 2020 Oct

Dig Dis Sci, 2022 Jun

Ann Surg, 2010 Feb

Neuroendocrinology, 2016 Jan 06

Ann Surg Oncol, 2023 May 19

Endocr Relat Cancer, 2023 May 1