Questions discussed in this category
Would you consider it for a patient who had bulky thoracic disease, with limited extrathoracic disease at diagnosis and achieved a CR after induction ...
What clinical factors do you take into consideration?
Would you recommend chemo-immunotherapy regimens for a fit patient who relapses at 6 mos post-t...
Does tumor size, age, or performance status play a role in your decision-making?
This has become standard practice at our institution for patients with a good performance status, with whole brain radiotherapy given after the comple...
Would the timing of the relapse (eg within 6 months) impact your decision making?
In elderly patients (>70-75) with a good performance status, does the risk of neurocognitive decline outweigh the benefit of PCI?
If yes, do you recommend it be given concurrently with chemotherapy or sequentially? What is your target volume and dose?
Would you offer topotecan, lurbinectedin, or another agent given the CNS progression as well?
Given that prophylactic cranial irradiation (PCI) has been shown to decrease the incidence of symptomatic brain metastases in patients with extensive ...
Are you routinely performing molecular sequencing? Would you modify your treatment approach in first or later lines based on PDL1 status?
If so, do you allow a period of "washout" between immunotherapy and radiation?
How do you decide between supportive care v. chemoimmunotherapy? Is there a threshold of disease burden that would push you towards recommending hospi...
Would you differentiate between patients with measurable disease vs NED? Are there specific data to guide us?
E.g. chemo/durvalumab vs chemo/atezolizumab?
What are the risks of infection with COVID-19 if using immunotherapy?
If you are using a standard 30/10 fractionation, is there a benefit to keeping chemo on board for radio-sensitization?
Would you consider adding atezolizumab to a cisplatin/irinotecan regimen, or cisplatin instead of carboplatin?
Does your practice differ based on limited or extensive stage disease?
Has the publication of IMpower133 changed standard of care?
Would you repeat PET or is it adequate to change to CT surveillance? Although surveillance PET/CT is not recommended by NCCN guidelines, these are oft...
Or would you wait to start coincident with the start of cycle 2? If a shorter time from the start of any therapy to the end of radiation (SER) is sign...
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Papers discussed in this category
N Engl J Med, 2007 Aug 16
J Clin Oncol, 1999 Jul
Lancet, 2015 Jan 3
International journal of radiation oncology, biology, physics, 2011-11-01
Int. J. Radiat. Oncol. Biol. Phys., 2006-09-01
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-12
Lancet Oncol., 2017-05-01
The New England journal of medicine, 1999-08-12
BMC Cancer, 2015-08-15
Journal of cancer research and therapeutics, 2012
International journal of radiation oncology, biology, physics, 2012-05-01
Neurosurgery, 2013-10
Practical radiation oncology, 2015
J. Neurosurg., 2005-01-01
J Korean Neurosurg Soc, 2011-08-01
Radiat Oncol, 2014-07-08
BMC Cancer, 2015-03-04
Acta Neurochir (Wien), 2013-01-01
The Lancet. Oncology, 2009-11
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007-04-01
J Clin Oncol, 2011 Jan 10
JAMA, 2016-07-26
Radiation oncology (London, England), 2014-09-30
Cancer, 2016-06-15
J. Clin. Oncol., 2018 May 22
Lung cancer (Amsterdam, Netherlands), 2018-06
The New England journal of medicine, 2018-08-23
The New England journal of medicine, 2018-12-06
International journal of radiation oncology, biology, physics, 2019-04-01
Lancet, 2019 Oct 04
JAMA oncology, 2019-06-01
International journal of radiation oncology, biology, physics, 2019-04-01
International journal of radiation oncology, biology, physics, 2019-04-01
Neurosurgery, 2019 Oct 10
JAMA Oncol, 2020 Jun 4
J Clin Oncol, 2020 Aug 10
Lung Cancer, 2014 Aug 02
N Engl J Med,
Lancet Oncol, 2020 Apr 03
Int J Radiat Oncol Biol Phys,
JAMA,
J Neurosurg,
Cancer,
Journal of the National Comprehensive Cancer Network : JNCCN, 2018-10
JAMA Netw Open, 2019 Aug 2
Pract Radiat Oncol, 2020 May - Jun
J Thorac Oncol, 2021 Feb 02
J Clin Oncol, 2021 Jan 27
Int J Radiat Oncol Biol Phys, 2020 Nov 18
J Clin Oncol, 2021 Aug 11
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-04-01
J. Clin. Oncol., 2020 Feb 14
Neuro Oncol,
J Clin Oncol, 2021 Aug 11
International journal of radiation oncology, biology, physics, 2011-09-01
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-01-01
Cancer, 2013-11-01
Journal of geriatric oncology, 2015-03
International journal of radiation oncology, biology, physics, 2013-07-15
Advances in radiation oncology, 2017
The Lancet. Oncology, 2009-05
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017-02
Cancer, 2010 Aug 27
J Clin Oncol, 2008 Dec 01
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-10
J Thorac Oncol, 2020 Sep 08
Lung Cancer, 2017 Jun
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2019-02
J. Clin. Oncol., 2012 Apr 02
J Clin Oncol, 2020 May 29
J Clin Oncol, 2021 Jan 13
Lancet Oncol, 2020 Dec 04
Lancet Oncol, 2020 Mar 27
Lancet Oncol,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-12-10
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015-08
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999-02
J Thorac Oncol. , 2019 Oct 17
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-12-01
Cancer Cell, 2018 May 03
Expert Opin Emerg Drugs, 2020 Aug 04
Lung Cancer, 2020 Sep 10
J Clin Oncol, 2020 Sep 10
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020 Jul 13