Medical Oncology

Small cell lung cancer   

Questions discussed in this category


Would you consider it for a patient who had bulky thoracic disease, with limited extrathoracic disease at diagnosis and achieved a CR after induction ...

What clinical factors do you take into consideration? Would you recommend chemo-immunotherapy regimens for a fit patient who relapses at 6 mos post-t...

This has become standard practice at our institution for patients with a good performance status, with whole brain radiotherapy given after the comple...

In elderly patients (>70-75) with a good performance status, does the risk of neurocognitive decline outweigh the benefit of PCI?

If yes, do you recommend it be given concurrently with chemotherapy or sequentially? What is your target volume and dose?

Given that prophylactic cranial irradiation (PCI) has been shown to decrease the incidence of symptomatic brain metastases in patients with extensive ...

Are you routinely performing molecular sequencing? Would you modify your treatment approach in first or later lines based on PDL1 status?

How do you decide between supportive care v. chemoimmunotherapy? Is there a threshold of disease burden that would push you towards recommending hospi...

Would you differentiate between patients with measurable disease vs NED?  Are there specific data to guide us?

What are the risks of infection with COVID-19 if using immunotherapy?  

If you are using a standard 30/10 fractionation, is there a benefit to keeping chemo on board for radio-sensitization?

Would you consider adding atezolizumab to a cisplatin/irinotecan regimen, or cisplatin instead of carboplatin?

Would you repeat PET or is it adequate to change to CT surveillance? Although surveillance PET/CT is not recommended by NCCN guidelines, these are oft...

Or would you wait to start coincident with the start of cycle 2? If a shorter time from the start of any therapy to the end of radiation (SER) is sign...


Papers discussed in this category


N Engl J Med, 2007 Aug 16

J Clin Oncol, 1999 Jul

Lancet, 2015 Jan 3

International journal of radiation oncology, biology, physics, 2011-11-01

Int. J. Radiat. Oncol. Biol. Phys., 2006-09-01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-12

Lancet Oncol., 2017-05-01

The New England journal of medicine, 1999-08-12

BMC Cancer, 2015-08-15

Journal of cancer research and therapeutics, 2012

International journal of radiation oncology, biology, physics, 2012-05-01

Neurosurgery, 2013-10

Practical radiation oncology, 2015

J. Neurosurg., 2005-01-01

J Korean Neurosurg Soc, 2011-08-01

Radiat Oncol, 2014-07-08

BMC Cancer, 2015-03-04

Acta Neurochir (Wien), 2013-01-01

The Lancet. Oncology, 2009-11

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007-04-01

J Clin Oncol, 2011 Jan 10

JAMA, 2016-07-26

Radiation oncology (London, England), 2014-09-30

Cancer, 2016-06-15

J. Clin. Oncol., 2018 May 22

Lung cancer (Amsterdam, Netherlands), 2018-06

The New England journal of medicine, 2018-08-23

The New England journal of medicine, 2018-12-06

International journal of radiation oncology, biology, physics, 2019-04-01

Lancet, 2019 Oct 04

JAMA oncology, 2019-06-01

International journal of radiation oncology, biology, physics, 2019-04-01

International journal of radiation oncology, biology, physics, 2019-04-01

Neurosurgery, 2019 Oct 10

JAMA Oncol, 2020 Jun 4

J Clin Oncol, 2020 Aug 10

Lung Cancer, 2014 Aug 02

N Engl J Med,

Lancet Oncol, 2020 Apr 03

Int J Radiat Oncol Biol Phys,

JAMA,

J Neurosurg,

Cancer,

Journal of the National Comprehensive Cancer Network : JNCCN, 2018-10

JAMA Netw Open, 2019 Aug 2

Pract Radiat Oncol, 2020 May - Jun

J Thorac Oncol, 2021 Feb 02

J Clin Oncol, 2021 Jan 27

Int J Radiat Oncol Biol Phys, 2020 Nov 18

J Clin Oncol, 2021 Aug 11

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-04-01

J. Clin. Oncol., 2020 Feb 14

Neuro Oncol,

J Clin Oncol, 2021 Aug 11

International journal of radiation oncology, biology, physics, 2011-09-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-01-01

Cancer, 2013-11-01

Journal of geriatric oncology, 2015-03

International journal of radiation oncology, biology, physics, 2013-07-15

Advances in radiation oncology, 2017

The Lancet. Oncology, 2009-05

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017-02

Cancer, 2010 Aug 27

J Clin Oncol, 2008 Dec 01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-10

J Thorac Oncol, 2020 Sep 08

Lung Cancer, 2017 Jun

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2019-02

J. Clin. Oncol., 2012 Apr 02

J Clin Oncol, 2020 May 29

J Clin Oncol, 2021 Jan 13

Lancet Oncol, 2020 Dec 04

Lancet Oncol, 2020 Mar 27

Lancet Oncol,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-12-10

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015-08

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999-02

J Thorac Oncol. , 2019 Oct 17

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-12-01

Cancer Cell, 2018 May 03

Expert Opin Emerg Drugs, 2020 Aug 04

Lung Cancer, 2020 Sep 10

J Clin Oncol, 2020 Sep 10

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020 Jul 13