Medical Oncology

NCI-CCC GU Tumor Board Question   

Questions discussed in this category



What imaging modality do you use (conventional, PSMA PET, etc.)? When do you image (ex: a PSA threshold or PSADT)?

Would you use it for initial staging or at time of biochemical recurrence?

Do you observe, offer adjuvant pembrolizumab, or give a first-line metastatic regimen (IO/IO or IO/TKI)? Does your recommendation vary based on risk c...

PSA rose from 25 to 30 ng/mL over 6 months on darolutamide for M0 CRPC, prompting scans which showed oligometastatic disease to bone, not amenable to ...

If any clinical benefit (ie. CR, PR or SD) would you consider switch maintenance avelumab, surveillance until progression, or an alternate regimen?

Molecular profiling revealed no targetable alterations, however tumor mutational burden was >10 mut/Mb.

Patient has progression of liver metastases while on pembrolzumab/axitinib. ECOG PS 1 and limited comorbidities.

GS 4+4. PSA low (1-2). CT and bone scan negative for lymphadenopathy or metastatic disease.  Prostate MRI pending. 

Does patient age effect your approach? Would you consider RPLND for any patients in light of the phase II SEMS trial presented at the 2021 ASCO GU Ca...

Do prior treatments for mHSPC change your thinking on whether or not to use sipuleucel-T?

What clinicopathological features would need to be present for you to recommend adjuvant chemotherapy? Would you treat pT3 disease? Any specific histo...

Specifically, would you offer salvage radiation to a patient who underwent a prostatectomy with PLND and had a post-op PSA of 12 with pathology reveal...

Specifically, for cT2N0M0 small cell bladder cancer without response to neoadjuvant cisplatin and etoposide on imaging, would you proceed with cystect...


Papers discussed in this category


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001-03-15

Clin Nutr, 2015 Aug 28

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-12-10

N. Engl. J. Med., 2017-07-27

Ann. Oncol.,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005-02-01

JAMA Oncol,

Urology, 2001-08

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-03-10

Journal of clinical pharmacology, 2010-04

BJU Int, 2011 Oct

Anticancer Drugs,

Cancer, 2010-11-15

Ann Oncol, 2010 Feb 12

N Engl J Med, 2021 Mar 4

Clinical genitourinary cancer, 2018-12

J Urol, 2020 Apr

Lancet, 2020 Mar 05

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-11-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-05-10

The New England journal of medicine, 2017-07-27

JAMA Oncol, 2021 Feb 18

Clinical genitourinary cancer, 2017-06

The Journal of urology, 2014-02

N. Engl. J. Med., 2019 Jun 02

N. Engl. J. Med., 2019 May 31

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-02-01

J. Clin. Oncol., 2019 Jul 22

Oncologist, 2020 Dec 03

International journal of radiation oncology, biology, physics, 2018-10-01

Urology, 2000-11-01

Abdom Radiol (NY), 2019 Aug 29

Lancet, 2021 May 07

N. Engl. J. Med., 2016-10-13

Lancet, 2020 Sep 28

Lancet Oncol,

Lancet Oncol,

J Urol, 2020 Apr 13

Eur J Nucl Med Mol Imaging, 2020 Aug 12

J Urol,

Clinical genitourinary cancer, 2018-06

Cancer treatment and research communications, 2019

Urology, 2013-06

Prostate Cancer Prostatic Dis, 2020 Feb 28

Cancer, 2019 Dec 1

J Clin Oncol, 2021 Feb 02

Lancet Oncol, 2020 Jan

Eur J Cancer, 2020 Jun 27

European urology focus, 2018-12

Int J Radiat Oncol Biol Phys, 2015 Jul 15

Clin Genitourin Cancer, 2019 Mar 28

Int J Radiat Oncol Biol Phys, 2021 Feb 06

Int J Cancer, 2018 May 10

J Urol, 2021 Feb 26

European urology, 2019-06

N Engl J Med, 2020 Sep 18

Cancer, 2020 Nov 20

BJU international, 2011-09

Cancer, 2009-09-15

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-04-01

Clinical genitourinary cancer, 2016-02

Cancer, 2019-05-01

European urology, 2017-07

Int Urol Nephrol, 2007 Mar 02

Clin Genitourin Cancer, 2017 Jul 22

Clin Genitourin Cancer, 2020 Feb 08

Eur Urol, 2019 Nov 08

J Clin Oncol,

J Urol, 2020 Jul

Clin Cancer Res, 2020 Jan 22

Cancer, 2021 Apr 21

Eur Urol Oncol, 2019 Sep 19

N Engl J Med,

Invest New Drugs, 2017 Oct 25

N. Engl. J. Med., 2012-04-19

Prostate cancer and prostatic diseases, 2018-04

JCO Precis Oncol, 2020

Lancet Oncol, 2019 Sep 09

Lancet, 2016 Mar 19

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-04-10

N Engl J Med, 2022 Feb 17

Prostate, 2022 Jun 08

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-06-10

Clinical genitourinary cancer, 2018-08

Lancet (London, England), 2019-06-15

Nature reviews. Urology, 2018-04

JAMA Oncol,

Clin Cancer Res, 2019 Sep 11

Nat Rev Urol, 2021 Jan 11

J Clin Oncol, 2022 Aug 30

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-05-10

Eur Urol Oncol, 2022 May 20

J Clin Oncol, 2021 Dec 20