Medical Oncology

Small cell lung cancer   

Questions discussed in this category


Are you routinely performing molecular sequencing? Would you modify your treatment approach in first or later lines based on PDL1 status?

Would you consider it for a patient who had bulky thoracic disease, with limited extrathoracic disease at diagnosis and achieved a CR after induction ...

How do you decide between supportive care v. chemoimmunotherapy? Is there a threshold of disease burden that would push you towards recommending hospi...

What clinical factors do you take into consideration? Would you recommend chemo-immunotherapy regimens for a fit patient who relapses at 6 mos post-t...

Would you differentiate between patients with measurable disease vs NED?  Are there specific data to guide us?

This has become standard practice at our institution for patients with a good performance status, with whole brain radiotherapy given after the comple...

If yes, do you recommend it be given concurrently with chemotherapy or sequentially? What is your target volume and dose?

What are the risks of infection with COVID-19 if using immunotherapy?  

If you are using a standard 30/10 fractionation, is there a benefit to keeping chemo on board for radio-sensitization?

Would you consider adding atezolizumab to a cisplatin/irinotecan regimen, or cisplatin instead of carboplatin?

Would you repeat PET or is it adequate to change to CT surveillance? Although surveillance PET/CT is not recommended by NCCN guidelines, these are oft...

Or would you wait to start coincident with the start of cycle 2? If a shorter time from the start of any therapy to the end of radiation (SER) is sign...


Papers discussed in this category


N Engl J Med, 2007 Aug 16

J Clin Oncol, 1999 Jul

Lancet, 2015 Jan 3

International journal of radiation oncology, biology, physics, 2011-11-01

Int. J. Radiat. Oncol. Biol. Phys., 2006-09-01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-12

Lancet Oncol., 2017-05-01

The New England journal of medicine, 1999-08-12

BMC Cancer, 2015-08-15

Journal of cancer research and therapeutics, 2012

International journal of radiation oncology, biology, physics, 2012-05-01

Neurosurgery, 2013-10

Practical radiation oncology, 2015

J. Neurosurg., 2005-01-01

J Korean Neurosurg Soc, 2011-08-01

Radiat Oncol, 2014-07-08

BMC Cancer, 2015-03-04

Acta Neurochir (Wien), 2013-01-01

JAMA, 2016-07-26

Radiation oncology (London, England), 2014-09-30

Cancer, 2016-06-15

The New England journal of medicine, 2018-12-06

Lancet, 2019 Oct 04

J Clin Oncol, 2020 Aug 10

Lung Cancer, 2014 Aug 02

N Engl J Med,

Lancet Oncol, 2020 Apr 03

N Engl J Med, 2017 Nov 16

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-10

J Thorac Oncol, 2020 Sep 08

Lung Cancer, 2017 Jun

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2019-02

J. Clin. Oncol., 2012 Apr 02

J Clin Oncol, 2020 May 29

J Clin Oncol, 2021 Jan 13

Lancet Oncol, 2020 Dec 04

J Thorac Oncol, 2021 Feb 02

Lancet Oncol, 2020 Mar 27

Lancet Oncol,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-12-10

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015-08

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999-02

J Thorac Oncol. , 2019 Oct 17

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-12-01

Cancer Cell, 2018 May 03

Expert Opin Emerg Drugs, 2020 Aug 04

Lung Cancer, 2020 Sep 10

J Clin Oncol, 2020 Sep 10