Pediatric Oncology

ALL   

Questions discussed in this category


What are the differences in approach to B lymphoid/myeloid and T lymphoid/myeloid MPAL?

What is the role of PD-1 inhibitors after CAR-T infusion, either as maintenance therapy or in the setting of relapsed disease? 

For patients not on study, would you consider replacing missed doses of peg with a non-asparaginase based chemotherapy?

Would you plan straight pediatric dosing using 2500 Units/m2 or a cap of 3750 Units as used in some adult ALL regimens due to excess liver/pancreas to...

Based on St. Judes, DFCI, and BFM data, COG has recently decreased the length of therapy for males with B-Cell ALL.  Can this be extrapolated to ...

With the new COG leukemia studies, it is difficult to interpret these results in the context of their clinical status and conventional MRD 

For example, if the patient was on dasatinib before relapse, would you consider other second generation or third generation TKIs?

Outcomes for these patients are dismal, so looking for any insight on how to optimize outcomes for these patients.

Do you limit it to post-pubertal patients? Do you offer it only if they will proceed with bone marrow transplantation after CAR-T?


Papers discussed in this category


Fertil. Steril., 2013 Sep 05

American journal of hematology, 2018-08

Blood, 2019-04-04

Am. J. Hematol., 2019 Nov 19

JAMA Oncol, 2020 Jan 16

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-04-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-04-01

British journal of haematology, 2012-05

Blood, 2018-05-17

Br J Haematol, 2020 Jan 24

Leukemia, 2014 Sep 02

Blood, 2018-08-23

Blood, 2018-07-19

, 2019 Oct 29

, 2018 Feb 27

Blood, 2020 Sep 23

Biol. Blood Marrow Transplant., 2019 Aug 22

Bone Marrow Transplant, 2018 Nov 01

Biol Blood Marrow Transplant, 2019 Aug 21

J Clin Oncol,

Leuk Lymphoma, 2019 Nov 04

J Clin Oncol, 2020 Apr 10

The Lancet. Oncology, 2017-09

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009-10

Journal of pediatric hematology/oncology, 2019-08

J Clin Oncol, 2021 Dec 9

Blood Cancer Discov, 2021 Dec 01

Pharmacogenomics,

Pediatr Blood Cancer, 2011 Feb 22

Pediatr Blood Cancer, 2011 Jul 27

Int J Hematol, 2021 Oct 28

Pharmacogenet Genomics,

Exp Hematol Oncol, 2021 Feb 19

Oncotarget,