Neuroendocrine Tumors   

Questions discussed in this category



Would a negative dotatate PET change management for a patient for whom you were planning to start SSAs?

Do you drop or adjust the temozolomide at any point, or rather continue to progression as long as temozolomide is well tolerated?

Which patients would you recommend active surveillance alone, a less morbid procedure such as enucleation, or a Whipple surgery? How does age influenc...

Pathology details: 75% high grade large cell neuroendocrine tumor of the cecum (20-30 mitoses per 10 hpf, Ki67 75%) and 25% adenocarcinoma. Patient ha...

Would there be any benefit to surgery in a healthy/good PS patient? There is so little data on pulmonary atypical carcinoid and radiation respons...

Would you use a small cell regimen over a more traditional FOLFOX-esque approach?

Is there a distinction between these tumors and patients with breast cancer with neuroendocrine features?

Does the advent of more effective therapies like peptide receptor radioligand therapy (PRRT) and capecitabine and temozolomide (CAPTEM) dampen enthusi...

Would you treat with typical small cell paradigms such as surgery followed by adjuvant platinum doublet +/- radiation vs definitive chemoradiation? Or...

Would the presence of peritoneal carcinomatosis change your treatment strategy? If Ki-67 <50%, would you avoid platinum based cytotoxics?

Would you consider first line treatment with somatostatin analog or Lu 177 dotatate? Is observation an option for asymptomatic patients?

Given the variable and sometimes indolent disease course of these patients, as well as the absence of a clear overall survival benefit in the PROMID&n...

There is some data on TMZ and 5FU based regimens, but convincing evidence is lacking. How would you approach this situation?


Papers discussed in this category


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Neuroendocrinology, 2017 Apr 13

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Lancet, 2019 Oct 04

Pancreas,

Front Endocrinol (Lausanne), 2020 Apr 29

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Clinical nuclear medicine, 2015-11

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Surgery, 2017 Jun 16

The New England journal of medicine, 2009-01-08

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Pancreas,

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Human pathology, 2016-03

Seminars in oncology, 2018-08

Pancreas, 2020 Aug

Neuroendocrinology, 2021 Feb 02

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Annals of surgical oncology, 2019-04

Eur Respir J, 2017 Oct 12

J Natl Compr Canc Netw, 2021 Aug 24

J Neuroendocrinol, 2022 Apr 05

Neuroendocrinology, 2019 Sep 17

Pancreas,

Endocrine-related cancer, 2015-06

Cancer, 2018-02-15

Clin Cancer Res, 2020 Sep 1

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Eur J Cancer, 2013 Jan 23

Ann Oncol, 2012 Sep 11

Endocr Relat Cancer, 2012 Nov 06

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Endocr Connect,

ESMO Open, 2021 Apr 23

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ERJ Open Res, 2020 Oct

Human pathology, 2018-09

Pancreas, 2020 Oct

Dig Dis Sci, 2022 Jun

Ann Surg, 2010 Feb

Neuroendocrinology, 2016 Jan 06