Medical Oncology

ASCO Journal Club   

Journal Club Q&A done in partnership with ASCO the Journal of Clinical Oncology

Questions discussed in this category


Data from the SOFT/TEXT trials showed clinical benefit in ovarian suppression + aromatase inhibition for high risk, premenopausal ...

Would you be more or less likely to use a cisplatin-containing regimen if a patient had previously responded to chemoradiation with concurrent cisplat...

Should this be done at the time of recurrence or after failure of 1st line therapy for recurrence?

There are now five PD-1/PDL-1 inhibitors approved for metastatic bladder CA, one (Atezolizumab) as first-line therapy in cisplatin-ineligible patients...

Can you extrapolate the data on Durable Complete Response After Discontinuation of Pembrolizumab in Patients With Metastatic Melanoma to patients on a...

In this study, doses of 2mg/kg Q3wks, 10mg/kg Q3wks and 10mg/kg Q2wks were used. What did the majority of these patients in CR receive? 

Are you using ctDNA blood tests for targetable mutations at the time of diagnosis, at the time of disease progression, or not at all?

Alternatively, would a biopsy of a metastatic bone lesion be preferred in a patient who has already progressed on chemo and hormonal therapy?

Given the FDA breakthrough therapy designation for olaparib in BRCA1/2 and ATM mutated mCRPC, when do you sequence mCRPC? Do you have a preferred...

Based on 2-3% MSH2 mutation and 1% MLH1 mutation rates in metastatic disease regardless of castration sensitivity, should we be looking for this earli...


Papers discussed in this category


JCO Precision Oncology, 2017 Sep 29

Sci Rep, 2014 Sep 09

Medicine (Baltimore),

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-10-01

JCO Precision Oncology, 2017 May 31

The New England journal of medicine, 2016-08-04

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-07-01

J. Clin. Oncol., 2019 Oct 16

Lancet (London, England), 2017-01-07

The New England journal of medicine, 2017-03-16

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-10

Nature medicine, 2017-06

Oncotarget, 2016-08-16

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-05-10

Oncotarget,

Nature, 2017-04-26

Cancer discovery, 2017-12

Cancer discovery, 2016-10

The Lancet. Oncology, 2016-11

The New England journal of medicine, 2017-10-05

Lancet (London, England), 2017-10-21

Nature, 2013-07-11

The New England journal of medicine, 2015-10-29

The New England journal of medicine, 2018-07-12

Clinical cancer research : an official journal of the American Association for Cancer Research, 2015-12-15

Lancet Oncol, 2013 Sep

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-01

J. Clin. Oncol., 2019 Apr 19

N Engl J Med, 2016 Feb 25

The New England journal of medicine, 2011-12-29

The New England journal of medicine, 2018-12-27

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-10

J Immunother Cancer, 2019 Aug 22

Journal for immunotherapy of cancer, 2017-11-21

Cancer management and research, 2017