Medical Oncology

UCLA   

Questions discussed in this category



Data from the SOFT/TEXT trials showed clinical benefit in ovarian suppression + aromatase inhibition for high risk, premenopausal ...

Personally, my practice is to guide patients directly to surgery or to do neoadjuvant chemotherapy rather than to do neoadjuvant endocrine therapy, bu...

Tamoxifen prophylaxis has not been studied in women <35 years old, but it would be reasonable to assume they would benefit.

Does the answer vary based on whether it is neo/adjuvant or metastatic setting?

Do you offer additional adjuvant chemotherapy, proceed to adjuvant endocrine therapy, or search for a suitable clinical trial?

Patient does not qualify for breast cancer screening by annual MRI per criteria (IBIS lifetime risk<20%, no known genetic predisposition,...

Following the dosage guidelines based on absolute neutrophil count may cause the patient to end up receiving lower doses.

This is in regards to the risk of secondary cancers after radiation therapy or cytotoxic chemotherapy (such as anthracyclines) in an immunosuppre...

What do you do with low grade (grade 1/3) tumors? In other words, does high grade pathology over rules?

Would you use a regimen with lower incidence of neurotoxicity such as CMF or a taxane-based regimen with a low threshold to dose-reduce?

Some patients request chemotherapy scheduling adjustments to avoid feeling ill on major holidays. Delaying chemotherapy by a few days isn't of particu...

Example case: Patient given neoadjuvant docetaxel + cyclophophamide achieves a partial response after 3 cycles of Taxotere + cyclophosphamide but is u...

Tamoxifen prophylaxis is FDA-approved, but would you extrapolate from adjuvant/metatastic data for hormone receptor positive breast cancer in post-men...

In the absence of data demonstrating a clinical benefit for one strategy versus the other, what do you do in practice?  

There is limited data that suggests steroidal AI exemestane could be of some benefit after nonsteroidal AI failure (Lonning PE et al. J Clin Oncol 200...


Papers discussed in this category


The New England journal of medicine, 2016-08-25

Lancet, 2017-09-09

The New England journal of medicine, 2012-08-02

Lancet (London, England), 2016-12-17

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-09-01

Breast cancer research and treatment, 2012-11

British journal of clinical pharmacology, 2016-06

Breast Cancer Res. Treat., 2005-01-01

Breast, 2016-12-01

Zhonghua Zhong Liu Za Zhi, 2016-07-01

Breast, 2016-08-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-05-10

J. Clin. Oncol., 2019 Oct 16

Cancer, 2010-11-15

The breast journal, 2017-11

The New England journal of medicine, 2011-06-23

Lancet (London, England), 2016-02-27

N. Engl. J. Med.,

Ann. Oncol.,

Lancet Oncol., 2016 Jun 23

The Lancet. Oncology, 2017-12

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-04-10

Lancet (London, England), 2013-03-09

J Clin Oncol, 2011 Jan 10

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-01-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-07-20

The Lancet. Oncology, 2016-04

Cancer control : journal of the Moffitt Cancer Center, 2009-01

JAMA, 2015-07-07

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-09-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-06-15

J. Natl. Cancer Inst.,

Lancet Oncol., 2012-01-01

The New England journal of medicine, 2019-02-14

The Lancet. Oncology, 2018-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-07-01

The New England journal of medicine, 2018-07-12

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-08-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-04-20