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Neurology

Vascular Neurology   

Questions discussed in this category

How would you approach antithrombotic therapy in patients with acute ischemic infarcts and a non-occlusive intracranial thrombus?
Would you adjust your approach based on the infarct size, symptom severity, or stroke etiology?
4 Answers available
How do you manage high-risk MDS IB2 patients on HMA and venetoclax who develop an acute stroke requiring antiplatelet therapy?
1 Answer available
For which stroke patients, if any, do you recommend implantable loop recorder for long-term cardiac monitoring and why?
It seems clear that longer monitoring yields more AF detected. What is less clear to me is whether all ILR-detected AF is relevant and merits anticoag...
4 Answers available
What is the optimal BP target for patients with diabetes and hypertension to reduce their risk of MI/stroke?
2 Answers available
How can you differentiate vessel wall enhancement related to CNS vasculitis versus atherosclerotic changes on MRA brain vessel wall imaging?
1 Answer available
When would you consider intra-arterial thrombolysis for acute ischemic stroke?
What are the main criteria for its consideration, and who would be an ideal candidate?
3 Answers available
Would you avoid triptans in patients with CADASIL?
1 Answer available
How safe and effective is carotid stenting in carotid dissection?
1 Answer available
Would you consider giving thrombolytic therapy for patients with acute vision loss concerning for CRAO based on history and within the window before any ophthalmological assessment and confirmation?
Would your approach differ through telemedicine for small ERs without access to onsite ophthalmology or neurology? 
3 Answers available
When do you consider attributing isolated psychosis to an acute ischemic stroke?
3 Answers available
In ischemic stroke patients with low LDL levels (<30-50 mg/dl), would you consider lowering LDL levels to lower values without concern for any side effects?
How would you adjust statin therapy in these patients?
5 Answers available
How does the presence of signs of cerebral edema influence your decision for thrombolysis and endovascular thrombectomy?
In light of publication in Ann Neurol by Nie et al based on ANGEL-ASPECT data
1 Answer available
How do you approach the decision of when to perform left heart catheterization in a patient with an NSTEMI who recently had an acute ischemic stroke?
1 Answer available
What imaging features can help distinguish between an acute versus chronic cervical internal carotid occlusion?
If there are signs of underlying atherosclerotic disease, are there signs to differentiate acute on chronic occlusion from chronic complete occlusion?...
1 Answer available
When do you consider thrombectomy for patients with LVO and carotid dissection?
4 Answers available
Would you recommend anticoagulation in a pediatric patient with metastases in a dural venous sinus?
1 Answer available
Do you recommend any medical management for patients with evidence of intracranial atherosclerosis without evidence for stroke?
4 Answers available
How would you approach the upfront management of a patient with acute unilateral vision loss with strong clinical risk factors for both cardioembolic stroke and GCA if an expedited MRI is not possible due to the presence of an AICD?
2 Answers available
What are current strategies to treat severe symptomatic basilar stenosis failing medical therapy?
3 Answers available
What is your preferred imaging modality for determining infarct core when evaluating acute stroke cases?
5 Answers available
Do you use dual anti-platelet therapy inpatients with low NIHSS who have had bilateral brainstem strokes?
1 Answer available
How do you decide when to pursue malignancy workup for patients with cryptogenic stroke?
3 Answers available
How do you evaluate and manage patients with recurrent multifocal subcortical ischemic infarcts of unclear etiology?
What potential etiologies would you consider in this case, and what corresponding diagnostic workup would be appropriate to evaluate them?
2 Answers available
Does anyone utilize P2Y12 assays to determine if clopidogrel may be ineffective when used for DAPT?
If yes, if the assay shows they are a non-responder, do you switch to ticagrelor?
6 Answers available
Do you consider bleeding risk in elderly, frail patients with atrial fibrillation to be similar for all NOACs?
In FRAIL-AF, participants were switched from VKA to dabigatran, rivaroxaban, apixaban, and edoxaban.
4 Answers available
What are your top takeaways from ISC 2025?
3 Answers available
What factors would guide your decision to safely resume anticoagulation for atrial fibrillation following a recent intracranial hemorrhage?
Question updated in light of Prestige AF trail. 
2 Answers available
What is the utility of a hypercoagulability workup in recurrent cryptogenic stroke, and what specific tests would you recommend?
Is there any utility in predominantly venous hypercoagulability labs?
7 Answers available
How would you evaluate and manage someone with leukoaraiosis and an acute ischemic stroke?
Would racial or genetic differences alter your workup and treatment? 
1 Answer available
Do you recommend endovascular therapy in patients with isolated posterior cerebral artery stroke?
1 Answer available
Should one perform a subsequent screening CTA or MRA head for mycotic aneurysm after cardio-embolic strokes in a setting of endocarditis with initial unremarkable CTA or MRA head/neck?
2 Answers available
What is your recommended long term management of extensive dural venous sinus thrombosis in an otherwise healthy young patient?
When would you stop anticoagulation?
4 Answers available
How do you approach long-term blood pressure parameters in ischemic stroke patients with severe symptomatic intracranial stenosis?
How do you balance between having a higher long-term blood pressure to prevent flow failure and leading to worsening of stenosis or occlusion from the...
2 Answers available
In patients with suspected RCVS, is there a role for preventative CCB if headache has resolved/now asymptomatic?
4 Answers available
How do you counsel patients who develop DVT or atrial fibrillation requiring anticoagulation when being treated with lecanemab or donanemab?
4 Answers available
What is the most updated consensus regarding the use of pill in the pocket oral anticoagulation in paroxysmal atrial fibrillation, and populations of patients who are most likely to be considered for enrollment in clinical trials?
Which DOAC(s) could be best suited for pill in the pocket anticoagulation RCTs?
2 Answers available
Regarding CVST, what protocol of heparin dosing do you regularly use and does it change depending on clot burden/ICH status?
Is there any evidence supporting the use of heparin boluses?
3 Answers available
How do you decide on the timing of carotid stenting after thrombectomy for an intracranial large vessel occlusion with ipsilateral carotid stenosis?
Are there specific characteristics of the plaque, such as the degree of stenosis or its morphology, that would influence your decision?
3 Answers available
Do you make any dose adjustments for patients with ESKD who are on apixaban and do not otherwise meet criteria for reduced dosing?
2 Answers available
How long would you continue chronic transfusion therapy for adult sickle cell patients who have had a stroke?
Is treatment indefinite or do you consider discontinuing chronic transfusions at some threshold?
2 Answers available
What is your clinical threshold for treating a potential monoclonal gammopathy of thrombotic significance?
New data suggests monoclonal gammopathies can be associated with thrombotic events. Is your practice changing to include monoclonal gammopathy evaluat...
1 Answer available
How do you approach interval monitoring of cavernous carotid aneurysms?
What is your preferred imaging modality as well as the recommended time interval for monitoring? Would your approach differ for intracranial aneurysms...
1 Answer available
How to approach reversal of TNK in hemorrhagic conversion of ischemic stroke?
Considering the short half-life, at what point would it be deemed too late to administer any reversal agent, and to consider withholding it?
2 Answers available
At what point should aspirin therapy for stable cardiovascular disease be discontinued in patients with a diagnosis of chronic cerebral microbleeds or possible Cerebral Amyloid Angiopathy?
2 Answers available
How do you manage headaches in stroke patients?
Is there a difference in headache management in ischemic stroke versus hemorrhagic stroke? How to best manage patients with underlying migraine who...
2 Answers available
How do you decide when to use andexanet (ANDEXXA) for intracranial hemorrhage associated with factor Xa inhibitors?
In light of ANNEXA-I RCT results: Connolly et al., PMID 38749032.
1 Answer available
For stroke patients with ablated paroxysmal atrial fibrillation without known recurrence and ICAD, would you recommend dual antiplatelet therapy or anticoagulation with or without an antiplatelet agent?
What is the duration of each treatment choice and which drug is preferred by either group? What else should we take into consideration when deciding o...
2 Answers available
Do all patients referred for acute symptoms of TIA or minor stroke require additional imaging with CT/MR angiography, in addition to admission/observation? 
Can some patients referred for TIA/stroke symptoms who have at the time of ER referral, a normal neurological exam be discharged with outpatient worku...
3 Answers available
How would you determine the safety of anticoagulation in patients with evidence of cerebral microhemorrhages who present with acute stroke secondary to cardioembolism?
4 Answers available
Would you recommend dual antiplatelet therapy or anticoagulation for a patient previously on aspirin who has a breakthrough stroke with history of CADASIL?
2 Answers available
What is the optimal antithrombotic management, if at all, in patients with incidentally identified findings of multiple silent embolic appearing cerebral infarcts?
3 Answers available
Do you ever use amantadine or modafinil to aid in the rehabilitation of patients with ischemic strokes?
In patients who have decreased arousal after ischemic stroke, do you use amantadine or modafinil to aid with wakefulness and interaction with therapy ...
3 Answers available
Would you consider using DOACs as a bridge to warfarin instead of heparin or LMWH?
For example, would you consider this method in an ESRD/HD patient with antiphospholipid syndrome who had a major bleed requiring reversal of warfarin ...
4 Answers available
When is air travel safe for patients with recent diagnosis of ischemic stroke?
1 Answer available
Can anti-cardiolipin or anti-beta-2 glycoprotein antibodies cause prolonged PTT in the absence of a lupus anticoagulant?
Labs with normal PT, but prolonged PTT (47 sec, ULN 40 sec) that does not correct on immediate mix. Lupus anticoagulant negative (DRVVT and hexagonal ...
1 Answer available
How would you manage a CVST secondary to a traumatic brain injury with the presence of intracranial hemorrhage?
When would you consider using anticoagulation and for how long?
4 Answers available
Would you consider skipping intravenous thrombolysis in patients with tandem occlusions who qualify for endovascular thrombectomy?
1 Answer available
When do you consider treating intracerebral hemorrhage associated with cerebral amyloid angiopathy as an inflammatory CAA?
How would you treat it?
1 Answer available
How do you counsel patients on the outcomes of endovascular treatment of acute basilar artery occlusion?
In light of one year follow-up results from ATTENTION trial
2 Answers available
Do you screen children with sickle cell disease for silent cerebral infarcts?
1 Answer available
When do you consider lumbar spinal fluid drainage after acute spinal cord injury?
1 Answer available
What is your approach to management and surveillance in low grade traumatic blunt ICA injury?
1 Answer available
What factors would influence your decision to use or avoid heparin bridging in patients with mechanical heart valves resuming anticoagulation after intracerebral hemorrhage?
In light of a publication by Sakusic et al., PMID 39102615 suggests an increased risk of ICH expansion in patients with heparin bridge compared to sta...
1 Answer available
When should one consider obtaining a cardiac MRI in ischemic stroke patients?
What is the utility of it? 
2 Answers available
How do you distinguish between episodes of vascular steal and seizures in patients with an AVM?
1 Answer available
What is your approach to secondary stroke prevention in patients with atrial fibrillation and intracranial stenosis (>70%)?
6 Answers available
Is moderate-intensity statin plus ezetimibe just as effective as high-intensity statin monotherapy in preventing major cardiovascular events?
4 Answers available
What is your approach to managing patients who initially present with symptomatic intracranial large vessel occlusion but subsequently experience resolution of symptoms or become non-disabling before any intervention?
Would your management be different if the LVO was found on imaging without preceding associated symptoms?
4 Answers available
Is there benefit of early initiation of antiplatelet therapy or DVT prophylaxis in patients who present with large MCA infarcts and are being considered for hemicraniectomy?
3 Answers available
How do you use cardiac biomarkers, if at all, in prognostication for patients with ischemic stroke?
In light of data from Chang et al in J Neurol Aug 2024 showing that biomarkers such as LDH and troponin were associated with adverse clinical outcomes...
0 Answers available
When do you consider testing with stroke gene panels in young stroke patients?
2 Answers available
Would you consider endovascular thrombectomy for acute stroke patients with large vessel occlusion (non-large core) but with poor functional baseline with mRS 3-4?
Which factors would influence your decision?
3 Answers available
What is your approach to the treatment of idiopathic intracranial hypertension with transverse sinus stenosis?
Do you favor specific medications or surgical interventions?
3 Answers available
How does premorbid dementia affect your decision to offer acute stroke intervention?
In light of the publication by Ganesh et al., PMID 39503052.
4 Answers available
How do you approach the treatment of biopsy proven ABRA (amyloid beta related angiitis)?
2 Answers available
How do you counsel patients on wearable heart monitor devices when they ask about specific products and diagnostic accuracy of these devices available on the market?
2 Answers available
What treatment do you use for stroke prevention in cervical artery dissection?
In light of the STOP-CAD study
2 Answers available
Does TpA or TNK cause acute post infusion severe headache with no intracranial bleed?
1 Answer available
Do you utilize thrombolytic therapy in patients with CRAO?
2 Answers available
How do you treat patients with stroke thought to be secondary to Lambl excrescence?
2 Answers available
Is there a role for using parenteral anticoagulation for occlusive extensive ICA thrombus with acute onset of symptoms when patients are not candidates for endovascular therapy, such as low NIHSS?
Would having infarct expansion during hospitalization change your approach?
2 Answers available
Do you recommend CT perfusion in patients presenting with symptoms of acute stroke before 6 hours?
7 Answers available
Is there a stroke volume threshold you use for giving or not giving DAPT for an acute ischemic stroke?
A large stroke in cortical regions might have a low NIHSS, while a small internal capsule lacune might have a large NIHSS. ICH risk is thought to be a...
1 Answer available
What is the value of sending placental pathology in neonatal patients who have suffered an in-utero arterial ischemic stroke?
1 Answer available
How do you manage patients with atrial fibrillation having a thromboembolic infarct despite being on adequate anticoagulation?
Would you recommend left atrial appendage occlusion with or without continuing anticoagulation? In light of Maarse et al., JAMA Neurology 2024.
3 Answers available
How do you determine which patients with ICAS are the best candidates for balloon angioplasty versus those who should continue with aggressive medical management alone?
In light of a recent publication by Sun et al., PMID 39235816 on the BASIS trial for balloon angioplasty for ICAS.
2 Answers available
When do you consider starting short-term DAPT in patients who present more than 24 hours after the onset of a high-risk TIA or minor stroke syndrome?
In light of the INSPIRES trial publication.
4 Answers available
What blood pressure targets do you enforce in the first 24-48 hours in a patient who develops an intracranial hemorrhage after mechanical thrombectomy?
Blood pressure targets for ischemic stroke and intracerebral hemorrhage are described in several guidelines. However, in patients with acute stroke wh...
2 Answers available
Would you discontinue romosozumab in a patient who develops a hemorrhagic stroke while on therapy?
5 Answers available
How do you medically manage acute basilar artery occlusion in patients with low NIHSS who are not candidates for EVT but at risk for deterioration?
2 Answers available
What considerations guide your decision to perform endovascular therapy in stroke involving acute M2 or M3 occlusions?
1 Answer available
Does aspirin dose (81 mg vs 325 mg) matter for secondary stroke prevention?
Should some patients get 325 mg instead of 81mg at least for a certain amount of time, such as patients in the acute phase of ischemic stroke or patie...
1 Answer available
When do you recommend hyperacute MRI for patients with wake-up stroke?
2 Answers available
Would you recommend a CT venogram or MR venogram in patients with concern for venous sinus thrombosis?
1 Answer available
Do you recommend encephaloduroateriosynangiosis in pediatric patients with Moyamoya disease?
1 Answer available
Do you recommend any particular type of contraceptive use in young patients with strokes of unclear etiology?
How do you guide what contraceptive type when asked by the medical team?
1 Answer available
Do you typically load DAPT in patients with ICAD?
2 Answers available
How do you manage patients with embolic stroke of an undetermined source and a papillary fibroelastoma found on an echocardiogram?
Are there specific mass features that would influence your treatment decision?
1 Answer available
When do you offer TNK for ischemic stroke patients with a large vessel occlusion presenting outside the 4.5-hour window?
In light of TIMELESS and TRACE-III trials.
2 Answers available
Do you prescribe prophylactic steroids to patients receiving radiosurgery for AVMs?
1 Answer available
Would you recommend a neck soft collar after a cervical internal carotid artery dissection?
If so, what is the typical duration?
1 Answer available
How would you best evaluate and manage a patient with hemiplegic migraine and a history of ischemic stroke?
1 Answer available
Would you consider starting dual antiplatelet therapy in a patient with evidence of petechial hemorrhage post-stroke secondary to ICAD?
1 Answer available
How do you manage patients with a prior intracerebral hemorrhage from probable cerebral amyloid angiopathy who develop new small vessel ischemic infarcts?
Would you consider using cilostazol instead of antiplatelets?
1 Answer available
Do you consider intervention vs medical therapy alone in patients with an ischemic stroke and suspected symptomatic ipsilateral carotid web with less than 50% stenosis?
1 Answer available
Is there a good rationale for using vasopressors/induced hypertension in a patient with fluctuating neurologic deficits from symptomatic intracranial stenosis?
3 Answers available
When do you consider stenting in patients with recurrent stroke with ICAD?
2 Answers available
What is the preferred approach to managing non-occlusive or partially occlusive venous sinus thrombosis?
1 Answer available
What is your approach to the management of asymptomatic intracranial atherosclerosis discovered during the workup of an acute stroke?
Does it influence your choice of antithrombotic therapy? Do you perform serial follow-up imaging?
3 Answers available
When do you consider patients with acute stroke with large vessel occlusion with very low ASPECTS scores (less than 3) for endovascular thrombectomy?
In light of meta-analysis data showing favorable outcomes in this normally excluded subset of patients (Katsanos et al., PMID 37775318).
1 Answer available
When would you consider neuro-stimulants in post-stroke patients?
Is there management guidance on when to start after stroke onset?
3 Answers available
What is your strategy for treating persistent headaches in the aftermath of subarachnoid hemorrhage?
Does your strategy change depending on whether or not it is a secured or unsecured aneurysmal SAH?
4 Answers available
Should follow-up imaging for unruptured intracranial aneurysms include MRA head and MRI brain to evaluate for arterial wall enhancement?
1 Answer available
What do you advise regarding the timing and safety of major surgery in patients with moderate to severe intracranial atherosclerosis?
Does your approach differ if the stenosis is symptomatic or flow-limiting?
1 Answer available
Would you recommend TNK or DAPT in patients with stroke-like symptoms and NIHSS less than 5 presenting within 4.5 hours?
4 Answers available
When is brain biopsy useful/warranted as part of the diagnostic work-up in patients with suspected primary CNS angiitis?
3 Answers available
Can bleeding risk when switching from VKA treatment to a NOAC in frail, elderly patients be accurately compared if individual times in therapeutic range while on VKA treatment are not captured?
Individual times in the therapeutic range while on VKA treatment was not registered in FRAIL-AF.
2 Answers available
Do you screen adults in your practice with sickle cell disease for silent cerebral infarcts?
The ASH 2020 guidelines have "recommended that adults with HbSS or HbSβ0 thalassemia be screened at least once for silent cerebral infarcts even ...
1 Answer available
Would you administer IV thrombolysis in a patient presenting with disabling stroke symptoms while on anti-amyloid therapy?
4 Answers available
When do you use MRI to further evaluate patients with non-traumatic subdural hemorrhage?
In light of the evidence associating cerebral amyloid angiopathy (CAA) with subdural hemorrhage from Andes et al in Neurology 2025 May and Rivier et a...
1 Answer available
Do you typically use NOACs or Lovenox in patients with stroke due to hypercoagulability from malignancy?
1 Answer available
Do you avoid SSRIs in patients with a history of RCVS?
2 Answers available
How often do you screen for cerebral aneurysms in patients with autosomal dominant polycystic kidney disease who do not have a family history of intracranial aneurysms or for whom the family history is unknown?
1 Answer available
When do you re-image patients with a diagnosis of venous sinus thrombosis?
2 Answers available
Should perfusion imaging be the standard of care in cases of a severe symptomatic intracranial stenosis?
If yes, is there a preference with MRI or CT technique?
5 Answers available
Is perfusion imaging reliable in determining stroke infarct vs. area at risk?
2 Answers available
How do you manage asymptomatic patients with incidental findings of the carotid web?
2 Answers available
Would you recommend genetic polymorphic testing before the initiation of antiplatelet medication in patients with ICAD?
4 Answers available
How do you manage incidentally found venous sinus thrombosis?
5 Answers available
Would you consider dual antiplatelet therapy for stroke prevention for ICAD in patients with a history of SAH?
2 Answers available
What criteria are used to choose a specific dose of aspirin in ischemic stroke?
We have seen 81 vs 162 vs 325 mg up to 1300 mg.
3 Answers available
Would you give TNK or IVT to a patient with proximal occlusion and an NIHSS of 0-3 (non-disabling)?
How about a distal occlusion? The patient was initially symptomatic but symptoms improved or mostly resolved.
5 Answers available
What duration of dual antiplatelet therapy do you use for secondary prevention of ischemic stroke due to intracranial atherosclerotic disease?
While some have the practice of 90 days per SAMMPRIS trial, the lower rates of ischemic stroke in the medical therapy group were driven by events with...
8 Answers available
Do you start aspirin for patients with incidentally found intracranial vertebral stenosis?
3 Answers available
When do you refer patients diagnosed with Moyamoya disease to neurosurgery?
2 Answers available
How do you address incidental small cerebellar infarcts seen on MRI?
This is not an infrequent finding in outpatient neurology practice, often in the absence of any lacunar disease in the typical regions, though I usual...
3 Answers available
How do you acutely manage a free-floating thrombus in a major artery in a patient with a stroke as a result of it?
4 Answers available
Would you change an elderly, frail patient with atrial fibrillation who is already on a NOAC to VKA treatment?
In FRAIL-AF, switching VKA therapy to a NOAC was associated with higher risk of bleeding in elderly, frail patients. 
4 Answers available
Do you think that home INR monitoring is a feasible option for elderly, frail patients with atrial fibrillation on VKA treatment, given variations in socioeconomic status and access to care?
2 Answers available
What would be the clinical benefit of multiphase CTA over CTP?
Should MTCTA be standard for anyone with LKN>=6h?
4 Answers available
Do you usually recommend PFO closure for patients with frequent migraines with aura?
1 Answer available
When do you restart antiplatelet therapy in patients with hemorrhagic conversion of stroke?
2 Answers available
What adjustments do you make to a hemodialysis prescription for a patient with a recent stroke?
3 Answers available
Would you recommend anti-platelet or anticoagulation in a patient with recurrent strokes, CADASIL, and Antiphospholipid Syndrome?
1 Answer available
Do you routinely screen for sleep apnea in patients with acute ischemic stroke?
3 Answers available
For patients with acute ischemic stroke and BP >185/110, at what point do you consider persistently elevated BP too refractory to safely give thrombolysis?
Current guidelines (AHA, ESO, etc.) are not clear. In addition, if a patient arrives with BP>240 how do you balance the risk of hypoperfusion with ...
4 Answers available
What is the recommended approach for extracranial bleeding after tPA?
Fibrinogen level >200.
2 Answers available
Considering only cerebrovascular indications, are there circumstances in which you would use aspirin along with a DOAC in patients with atrial fibrillation and stroke?
6 Answers available
In antiphospholipid syndrome with recurrent strokes, would you consider adding antiplatelets to warfarin?
Also how would you manage this perioperatively?
7 Answers available
For patients with ischemic stroke status-post decompressive hemi-craniectomy, when should they start aspirin for secondary stroke prevention?
For patients with ischemic stroke status-post decompressive hemi-craniectomy, when should they start aspirin for secondary stroke prevention? POD 5? P...
2 Answers available
How do you approach a patient with atrial fibrillation on apixaban who has a new cardioembolic stroke?
3 Answers available
In patients with Afib on anticoagulation and concurrent intracranial atherosclerotic disease, would you consider adding an anti-platelet to anticoagulation if there are recurrent events that could be related to the ICAD?
1 Answer available
In patients with embolic stroke and a PFO, how often do you go beyond venous Doppler of the lower extremities to screen for DVT (e.g. MRV or CTV abdomen and pelvis)?
Would you anticoagulate if this screening is negative pending PFO closure?
1 Answer available
Would you start anticoagulation in a patient with a history of CVA 1 year ago and high risk APL profile who was never started on anticoagulation, but is now presenting for follow up and without recurrent thrombotic events?
The patient has no known history of autoimmune disease.
4 Answers available
Is there a preference between the different high-intensity statins for high-risk stroke patients?
How does pravastatin differ in advantage from other high-intensity statins?
3 Answers available
Does the presence and location of cerebral microbleeds affect your decision for antithrombotic treatment in patients with atrial fibrillation?
Do you distinguish between primary and secondary prevention? Wilson et al., PMID 31130428 is helpful, but curious how people apply this data in practi...
3 Answers available
When can you utilize external ventricular drains (EVDs) in the management of posterior fossa strokes?
Do all malignant posterior fossa infarcts need sub-occipital craniectomy or are there a subset of cases that can be managed with EVD? 
1 Answer available
What additional testing besides LAC/APLS, factor V Leiden, prothrombin gene mutation, JAK 2 do you draw for unprovoked cerebral venous sinus thrombosis?
1 Answer available
Would you recommend PFO closure in patients >60 years old with presumed paradoxical embolism as their mechanism of stroke?
2 Answers available
What guidance do you provide for anesthesia in patients with incidentally found carotid web?
1 Answer available
Do you recommend life long aspirin 81 mg daily for non-specific T2 white matter hyper-intensities on MRI brain?
7 Answers available
What blood pressure goals do you typically target for patients in the immediate post thrombectomy period?
2 Answers available
Do you typically recommend inpatient stroke evaluation for patients with incidentally found asymptomatic stroke on outpatient imaging?
For patients undergoing outpatient MR imaging for other indications who have instantly found acute stroke, do you typically recommend the patient be a...
5 Answers available
Do you consider a severe ICA stenosis (70-99% narrowing per NASCET criteria) symptomatic if a lacunar stroke attributable to small vessel disease occurs in the perforating arteries (e.g. lenticulostriate) downstream from the stenosis?
Do you offer this person a vascular intervention (i.e., CEA or stenting)?
1 Answer available
What pre-operative work-up do you follow in your institution prior to EC-IC bypass in patients with a focal intracranial stenosis and patients with MMD?
1 Answer available
Is there a role to continue aspirin in patients with myeloproliferative disorders who have never had a thrombotic event that are starting DOAC for stroke prophylaxis with newly diagnosed atrial fibrillation?
2 Answers available
How long do you wait before foley or IV placement in patients who have recieved TNK or TPA?
3 Answers available
How do you define impaired distal fusion in patients with ICAD?
In what ways, if any, does the timing of perfusion imaging from onset of stroke symptoms affect its utility in informing quality of distal perfusion?
2 Answers available
Would you recommend switching to DAPT for patients on anticoagulation who develop symptoms of a TIA secondary to ICAD?
3 Answers available
How can you differentiate perforator disease vs artery-to-artery embolus as a stroke etiology?
1 Answer available
How would you manage anti-platelet therapy in patients presenting with ischemic stroke and have a history of von Willebrand disease?
1 Answer available
What antithrombotic regimen do you recommend prior to and in anticipation of CEA for patients with symptomatic carotid stenosis?
2 Answers available
Would you give IV thrombolysis to a patient presenting with acute disabling stroke symptoms after a TAVI procedure?
1 Answer available
When do you start anticoagulation in patients with endocarditis and evidence of mycotic aneursym?
3 Answers available
How will you treat a young man with recurrent cryptogenic strokes with no identifiable cause, with MTHFR A1298C homozygous mutation and normal homocysteine level?
1 Answer available
Do you typically recommend four factor prothrombin complex concentrate versus fresh frozen plasma for INR correction in patients with vitamin K antagonist associated spontaneous ICH?
4 Answers available
Is angioedema secondary to IV tPA considered an absolute contraindication for tPA in future?
3 Answers available
Is LP indicated for patients with recurrent thunderclap headaches over a 4-week period and negative head imaging for SAH?
2 Answers available
Do you recommend antiplatelet therapy for patients who have suffered stroke due to CADASIL?
3 Answers available
Would you favor restarting anticoagulation or pursuing left atrial appendage closure in a patient with hemorrhagic stroke on anticoagulation for non-valvular atrial fibrillation?
3 Answers available
What is your practice for the timing of resumption of oral anticoagulation after ICH?
Do you order any imaging beforehand? Are there other studies that you order?  
1 Answer available
What is the recommended management approach in regard to diagnostic evaluation and treatment for patients with homocystinuria and cerebral thrombosis?
Do we prophylactically place patients on anticoagulation after one episode? Besides MRI/MRV brain, are there other diagnostic imaging that should b...
1 Answer available
Are triptans contraindicated in patients with Moya Moya syndrome who have never had an ischemic stroke?
2 Answers available
Do you typically recommend platelet transfusions in patients with spontaneous ICH?
Do you have a particular cutoff?
2 Answers available
When do you recommend MRA in patients with spontaneous ICH and negative CTA?
Do you ever recommend any specific sequences on MRA?
3 Answers available
Do you typically recommend CT angiogram and CT venogram to assess for patients with lobar spontaneous ICH?
2 Answers available
Do you always pursue stroke work up in patients diagnosed with transient global amnesia?
For patients clinically presenting with Transient Global Amnesia and no other focal neurologic deficits, do you always pursue work up to rule out stro...
8 Answers available
Does the overall conclusion of the CHANCE-2 trial make ticagrelor + ASA a worthwhile transition given the data showing cumulative hazard of stroke diverged during the first week and was subsequently similar, which suggests the benefit of ticagrelor over clopidogrel is seen predominantly soon after stroke?
4 Answers available
Is there a risk of CYP2C19 gene testing only being adopted by wealthier health systems, thereby creating a disparity gap in treatment?
What is the cost and accessibility of CYP2C19 gene testing? Does the limited availability of rapid genotyping techniques limit the clinical applicabil...
3 Answers available
Do you ever do surveillance MR imaging in patients with stable exam and history of cardioembolic stroke?
1 Answer available
Would you generalize the data from the CHANCE-2 trial to a broader clinic population given that the study was specific to Han Chinese patients?
How do you plan to incorporate the results of the CHANCE-2 trial (Wang et al., PMID 34708996) in your own practice?
3 Answers available
Do you recommend genetic testing after a patient on clopidogrel has a stroke based on the results of the CHANCE-2 trial?
3 Answers available
Would you consider anticoagulation for a young patient with a recent embolic stroke and newly diagnosed global cardiac hypokinesis with ejection fraction of less than 25%?
No thrombus detected on echocardiogram and no evidence of atrial fibrillation is present.
1 Answer available
Would you recommend short-term dual antiplatelet therapy for a patient who received tPA, and is otherwise eligible for dual antiplatelet therapy per POINT or SAMMPRIS trial?
3 Answers available
What is your approach for a patient with an acute ischemic stroke caused by an aortic thrombus?
2 Answers available
How would you approach protein S deficiency found on hypercoagulability work-up in a patient with a post-operative central retinal vein occlusion?
In the setting of no personal or family history and no other risk factors for thrombosis, is systemic anticoagulation warranted if local treatments (e...
4 Answers available
How long after starting anticoagulation would you remove an IVC filter in a patient with a DVT presenting with stroke and PFO which is now closed?
1 Answer available
What is your approach to a patient who has an ischemic stroke while on clopidogrel despite strict compliance and normal results on clopidogrel response assay?
5 Answers available
How do you decide between TCAR vs. carotid stenting for patients unstable for CEA?
2 Answers available
When do you start anticoagulation in a patient with cardioembolic CVA secondary to new onset atrial fibrillation with hemorrhagic conversion?
1 Answer available
How does evidence of cerebral amyloid angiopathy/microbleeds affect choices for secondary stroke prevention in patients with a history of ischemic stroke and atrial fibrillation?
How do you approach secondary stroke prevention for patients with ischemic stroke, atrial fibrillation, and signs of cerebral amyloid angiopathy/micro...
1 Answer available
How do you determine timing and frequency of stability scans for a patient with spontaneous, non-aneurysmal intracerebral hemorrhage?
What factors influence your thinking?
1 Answer available
Do you use a combination of anticoagulant and antiplatelet therapy for treating intraluminal internal cerebral artery thrombus causing stroke?
For what duration do you use therapy?
1 Answer available
Would it be prudent to complete long term cardiac monitoring (ie. 30 day) in a patient with a new typical appearing lacunar type thalamic infarct and history of hypertension?
1 Answer available
Is antiplatelet or anticoagulant therapy preferred for the secondary prophylaxis of cryptogenic stroke in a patient with underlying malignancy?
4 Answers available
Do you treat cerebral vein thrombosis with parenchymal hemorrhage using full dose heparin protocol rather than the high risk protocol?
1 Answer available
Do you start anticoagulation in a patient with infective endocarditis who also has atrial fibrillation and stroke?
1 Answer available
When do you consider middle meningeal artery embolization in patients with recurrent subdural hemorrhages?
In what clinical scenario would you refer a patient for embolization? Are there any contraindications? 
1 Answer available
How do you determine if a patient is safe to drive after having a PCA infarct?
What is the best way to determine if patients with new PCA territory infarct can drive? Upon discharge from the hospital, do you routinely refer them ...
1 Answer available
What is your steroid-sparing agent of choice to treat GCA given the current tocilizumab shortage?
Thoughts on sarilumab vs methotrexate, or just treat with steroids alone
1 Answer available
How do you treat patients with symptoms of acute ischemic stroke who have an allergic reaction to alteplase?
How would you treat patients with symptoms of AIS who have an allergic reaction to TPA with no evidence of large vessel occlusion on imaging? What nex...
1 Answer available
When do you start anticoagulation for secondary prevention in patients with HFrEF and history of embolic strokes?
For a relatively young, medically compliant patient with HFrEF (EF<35%) and h/o embolic stroke, what is the consensus of starting AC for secondary ...
1 Answer available
When is the best time to consider left atrial appendage closure for secondary stroke prevention in patients with atrial fibrillation?
For example, with a Watchman device? What is the evidence behind this?
1 Answer available
When do you restart anticoagulation in patients with atrial fibrillation who just had an ischemic stroke?
Would you change your practice in light of the recently published studies:  OPTIMAS Trial & Elan Trial
1 Answer available
When do you consider starting hypertonic saline solution in patients with an acute ischemic stroke?
1 Answer available
How do you approach management of cerebral venous sinus thrombosis in a patient with severe thrombocytopenia?
1 Answer available
How do you determine the timing of anticoagulation for patients with large MCA strokes secondary to atrial fibrillation?
1 Answer available
Should patients with cerebral amyloid angiopathy have any statin medications discontinued?
1 Answer available
In what clinical settings is acute ICH clot removal recommended?
1 Answer available
In patients with recurrent ischemic infarcts on the same side as an internal carotid artery lesion, is intervention warranted even if there is less than 50% obstruction?
When would you consider stenting or CEA even if there is less than 50 obstruction when no other etiology has been found?
1 Answer available
How do you limit the onset of new strokes in patients with Moya-Moya syndrome?
1 Answer available


Papers discussed in this category

American journal of hematology, 2023 May 12
An integrated therapeutic approach to sickle cell disease management beyond infancy.
The New England journal of medicine, 2014 Aug 21
More blood for sickle cell anemia?
Stroke, 2020 Aug 06
Anticoagulation Type and Early Recurrence in Cardioembolic Stroke: The IAC Study.
Neurology. Clinical practice, 2018-02
Anticoagulation for atrial fibrillation after intracranial hemorrhage: A systematic review.
The New England journal of medicine, 2021 May 15
Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
Lancet (London, England), 2025 Feb 26
Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial.
Stroke, 2015 May 28
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.
Stroke, 2019-02
Ischemic Stroke and Internal Carotid Artery Web.
Stroke, 2011-04
Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association.
Ann Neurol, 2020 Aug 05
Anticoagulation Timing in Cardioembolic Stroke and Recurrent Event Risk.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019-08
Treatment Approaches to Lacunar Stroke.
Stroke, 2021 Sep 14
Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities.
Stroke, 2015-03
Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis.
BMJ open, 2014-12-02
Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study.
J Am Coll Cardiol,
Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial.
Neurology, 2015-09-29
Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE.
Stroke, 2017-08
Challenges in the Medical Management of Symptomatic Intracranial Stenosis in an Urban Setting.
Stroke, 2021 May 24
2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.
Lancet (London, England), 2014-01-25
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
Circulation, 2019-08-20
Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke.
J Neurol, 2021 Jul 17
Frequency of silent brain infarction in transient global amnesia.
J Vasc Surg, 2019 Dec 31
Duration of blood flow reversal during transcarotid artery revascularization does not affect outcome.
The New England journal of medicine, 2012-05-17
Warfarin and aspirin in patients with heart failure and sinus rhythm.
The New England journal of medicine, 2018-10-04
Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.
The New England journal of medicine, 2019-05-16
Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.
Heart, 2019 Apr 08
Anticoagulation therapy in heart failure and sinus rhythm: a systematic review and meta-analysis.
N Engl J Med,
Trial of Tocilizumab in Giant-Cell Arteritis.
Lancet, 2016 Mar 04
Tocilizumab for induction and maintenance of remission in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial.
Arthritis Rheum,
Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis.
American heart journal, 2010-07
Cryptogenic Stroke and underlying Atrial Fibrillation (CRYSTAL AF): design and rationale.
Lancet, 2021 Aug 27
Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial.
Neurology, 2019 Jan 11
RCVS score and diagnostic approach for reversible cerebral vasoconstriction syndrome.
The New England journal of medicine, 2013-03-21
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.
Neurology, 2013-08-13
An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke.
The New England journal of medicine, 2017-09-14
Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.
Circ Cardiovasc Interv, 2022 Jun 23
Transcatheter Closure of Patent Foramen Ovale in Older Patients With Cryptogenic Thromboembolic Events.
JAMA, 2021 Dec 14
Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.
JAMA Neurol, 2020 Jul 01
Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke.
JAMA Neurol, 2022 Nov 01
Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure.
Neurology, 2015-10-13
Clinical Reasoning: An 87-year-old woman with left-sided numbness.
JAMA,
Effect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: The STROKE-AF Randomized Clinical Trial.
eNeurologicalSci, 2017 Aug 02
Successful systemic thrombolysis with rtPA in a patient with history of a life-threatening rtPA-associated orolingual angioedema.
Neurol Clin Pract,
Thrombolysis of a stroke patient with history of rtPA-associated angioedema.
J Am Heart Assoc, 2020 Nov 23
Direct Oral Anticoagulants in Patients With Inherited Thrombophilia and Venous Thromboembolism: A Prospective Cohort Study.
Am J Hematol,
Protein S abnormalities: a diagnostic nightmare.
Eur J Neurol, 2017 Aug 20
European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology.
Stroke, 2016 Dec 20
Optimal Timing of Anticoagulant Treatment After Intracerebral Hemorrhage in Patients With Atrial Fibrillation.
Stroke, 2010 Oct 28
Optimal timing of resumption of warfarin after intracranial hemorrhage.
J Thromb Haemost, 2010 Apr 08
Management of anticoagulation following central nervous system hemorrhage in patients with high thromboembolic risk.
Lancet Neurol, 2021 Sep 03
Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial.
The New England journal of medicine, 2018-07-19
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
N Engl J Med, 2013 Jun 26
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.
N Engl J Med, 2021 Oct 28
Ticagrelor versus Clopidogrel in Loss-of-Function Carriers with Stroke or TIA.
N Engl J Med,
Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.
JAMA neurology, 2019-04-01
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.
Lancet Neurol, 2019 May 23
Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.
JAMA Neurol,
Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016.
Lancet Neurol, 2018 Jan 10
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study.
Cancer causes & control : CCC, 2010-03
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Atherosclerosis, 2001-06
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
The American journal of clinical nutrition, 2008-10
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Circulation. Cardiovascular genetics, 2008-12
Variants of folate metabolism genes and the risk of conotruncal cardiac defects.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012-01
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
Human genetics, 2012-05
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.
PeerJ, 2013
Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.
Nature, 2016-08-18
Analysis of protein-coding genetic variation in 60,706 humans.
Am J Hum Genet, 1998 May
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Am J Reprod Immunol, 2011 Jan 18
Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss.
Am J Reprod Immunol, 2012 Aug 06
Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome.
BMC Cancer, 2008 Nov 07
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
BMJ Case Rep, 2012 Nov 15
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation.
BMJ Case Rep, 2013 Jun 13
Bilateral consecutive optic neuropathy in a patient with thrombophilia.
Mol Biol Rep, 2010 Jun 08
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk.
Mol Biol Rep, 2010 Nov 16
Association of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer cases.
Nat Genet, 2008 Jul
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Proc Natl Acad Sci U S A, 2001 Mar 13
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Mol Biol Rep, 2018 Mar 29
CBS mutations and MTFHR SNPs causative of hyperhomocysteinemia in Pakistani children.
Transfus Apher Sci, 2014 Jan 08
Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphisms with retinal vein occlusion in Tunisian patients.
J Matern Fetal Neonatal Med, 2015 Jul 02
Thrombophilic genes alterations as risk factor for recurrent pregnancy loss.
Clin Neurol Neurosurg, 2013 Mar 21
Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.
J Hum Genet, 2006 Feb 18
MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers.
Circulation, 2009-03-31
Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial.
Cerebrovascular diseases (Basel, Switzerland), 2014
Recurrent stroke in the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial.
JAMA Neurol,
Left Ventricular Dysfunction Among Patients With Embolic Stroke of Undetermined Source and the Effect of Rivaroxaban vs Aspirin: A Subgroup Analysis of the NAVIGATE ESUS Randomized Clinical Trial.
The New England journal of medicine, 2012-03-01
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Neurocritical care, 2020 Aug
Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review.
Neurocritical care, 2021 Feb
Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients.
Stroke, 2017 Apr 12
MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.
The New England journal of medicine, 2011-12-01
Effect of two intensive statin regimens on progression of coronary disease.
The New England journal of medicine, 2018-11-29
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.
Circulation, 2019 Nov 11
Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES.
N Engl J Med, 2017 Mar 17
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.
Stroke, 2020 Apr 21
Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis.
Lancet, 2016 May 10
Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial.
J Neurol Neurosurg Psychiatry, 2016 May 13
Early blood pressure lowering in patients with intracerebral haemorrhage and prior use of antithrombotic agents: pooled analysis of the INTERACT studies.
J Am Heart Assoc, 2021 Feb 15
Outcomes in Antiplatelet-Associated Intracerebral Hemorrhage in the TICH-2 Randomized Controlled Trial.
Neurology, 2010 Sep 08
Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review.
Arthritis and rheumatism, 2007-07
Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals.
Stroke, 2014-07
Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.
Cochrane Database Syst Rev, 2020 Oct 12
Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
Archives of internal medicine, 1997-10-13
A retrospective review of 61 patients with antiphospholipid syndrome. Analysis of factors influencing recurrent thrombosis.
Lupus, 2011-02
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies.
Annals of the rheumatic diseases, 2019-10
EULAR recommendations for the management of antiphospholipid syndrome in adults.
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Diagnosis and Management of the Antiphospholipid Syndrome.
Lupus,
16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends.
J Autoimmun, 2018 Feb 13
The treatment of anti-phospholipid syndrome: A comprehensive clinical approach.
Int J Med Sci, 2009 Dec 05
Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome.
Blood Adv,
ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease.
The New England journal of medicine, 2018-02-15
Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism.
N Engl J Med, 2020 Mar 29
Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer.
N Engl J Med, 2003 Jul 10
Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.
Stroke, 2013-10
Thrombolysis for ischemic stroke associated with infective endocarditis: results from the nationwide inpatient sample.
Stroke, 2016-01
Dynamic Angiographic Nature of Cerebral Mycotic Aneurysms in Patients With Infective Endocarditis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019-08
Acute Ischemic Stroke Therapy in Infective Endocarditis: Case Series and Systematic Review.
Journal of the neurological sciences, 2019-08-15
Clinical course of infectious intracranial aneurysm undergoing antibiotic treatment.
JAMA, 2018-07-10
Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial.
European stroke journal, 2017 Nov 29
Minor stroke due to large artery occlusion. When is intravenous thrombolysis not enough? Results from the SITS International Stroke Thrombolysis Register.
Frontiers in neurology, 2021 Sep 07
Treatment Challenges in Acute Minor Ischemic Stroke.
Neuroradiology, 2020 Sep 08
Radiation exposure of computed tomography imaging for the assessment of acute stroke.
N Engl J Med, 2005 Mar 31
Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.
Neurology, 2017-01-24
Relationship between risk factor control and vascular events in the SAMMPRIS trial.
JAMA neurology, 2020 Aug 01
Effect of Endovascular Treatment With Medical Management vs Standard Care on Severe Cerebral Venous Thrombosis: The TO-ACT Randomized Clinical Trial.
Stroke, 2023 Sep 07
Study of Rivaroxaban for Cerebral Venous Thrombosis: A Randomized Controlled Feasibility Trial Comparing Anticoagulation With Rivaroxaban to Standard-of-Care in Symptomatic Cerebral Venous Thrombosis.
Stroke, 2019-04
WEAVE Trial: Final Results in 152 On-Label Patients.
J Neurointerv Surg, 2020 Jun 19
The WOVEN trial: Wingspan One-year Vascular Events and Neurologic Outcomes.
JAMA network open, 2025 Apr 01
Cytochrome P450 2C19 Genotypes and Clopidogrel in Patients With Ischemic Stroke: A Nonrandomized Clinical Trial.
J Int Med Res, 2017 Jan 25
Digestive and urologic hemorrhage after intravenous thrombolysis for acute ischemic stroke: Data from a Chinese stroke center.
Stroke, 2017-02
Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.
J Clin Med, 2020 Mar 10
Cerebral and Splanchnic Vein Thrombosis: Advances, Challenges, and Unanswered Questions.
Hematology Am Soc Hematol Educ Program, 2021 Dec 10
Clots in unusual places: lots of stress, limited data, critical decisions.
JAMA Neurol, 2019 Dec 01
Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis: A Randomized Clinical Trial.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2021 Oct 14
Validity of ICD-10 Codes for Cerebral Venous Thrombosis Depends on Clinical Context.
Lancet, 2022 Oct 28
Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial.
CJEM, 2017 Jun 09
Intensive blood-pressure lowering in patients with acute cerebral hemorrhage.
Hemodialysis international. International Symposium on Home Hemodialysis, 2013 Oct
Changing the hemodialysis prescription for hemodialysis patients with subdural and intracranial hemorrhage.
Circulation, 2023 Aug 27
Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial.
Circulation, 2020 May 21
The COMPASS Trial: Net Clinical Benefit of Low-Dose Rivaroxaban Plus Aspirin as Compared With Aspirin in Patients With Chronic Vascular Disease.
British journal of haematology, 2024 Sep 02
Measurement of heparin, direct oral anti-coagulants and other non-coumarin anti-coagulants and their effects on haemostasis assays: A British Society for Haematology Guideline.
Lancet (London, England), 2018-08-04
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials.
JAMA, 2023 Jun 27
Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial.
Lancet (London, England), 2014-11-29
Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.
Stroke, 1997 Nov
Generalized efficacy of t-PA for acute stroke. Subgroup analysis of the NINDS t-PA Stroke Trial.
The New England journal of medicine, 2023 Jan 04
Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke.
The journal of prevention of Alzheimer's disease, 2023
Lecanemab: Appropriate Use Recommendations.
Kidney360, 2023 Nov 22
All Patients with ADPKD Should Undergo Screening for Intracranial Aneurysms: PRO.
JAMA neurology, 2018-12-01
Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial.
Stroke, 2015 Nov 03
Modafinil May Alleviate Poststroke Fatigue: A Randomized, Placebo-Controlled, Double-Blinded Trial.
Stroke, 2005 Dec 01
Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial.
Blood advances, 2020 Jun 23
American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain.
Radiology, 2016-06
Analysis of Workflow and Time to Treatment and the Effects on Outcome in Endovascular Treatment of Acute Ischemic Stroke: Results from the SWIFT PRIME Randomized Controlled Trial.
Neurologia medico-chirurgica, 2021 Dec 24
Randomized Clinical Trial of Endovascular Therapy for Acute Large Vessel Occlusion with Large Ischemic Core (RESCUE-Japan LIMIT): Rationale and Study Protocol.
The New England journal of medicine, 2023 Feb 10
Trial of Endovascular Thrombectomy for Large Ischemic Strokes.
The New England journal of medicine, 2023 Feb 10
Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct.
Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2007-01
The Spencer's Curve: clinical implications of a classic hemodynamic model.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2010
Intracranial atherosclerosis as a risk factor for ischemic stroke during open heart surgery.
Circulation, 2021 Apr 08
Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery: A Scientific Statement From the American Heart Association/American Stroke Association.
Journal of the American College of Cardiology, 2011 May 03
Stroke risk after coronary artery bypass graft surgery and extent of cerebral artery atherosclerosis.
JAMA, 2014 Jul 16
Time elapsed after ischemic stroke and risk of adverse cardiovascular events and mortality following elective noncardiac surgery.
JAMA surgery, 2022 Aug 10
Association of Time Elapsed Since Ischemic Stroke With Risk of Recurrent Stroke in Older Patients Undergoing Elective Nonneurologic, Noncardiac Surgery.
European journal of neurology, 2020 Mar 20
Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology.
PloS one, 2016 Jun 16
CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships.
Stroke, 2023 Aug 21
Management of Inherited CNS Small Vessel Diseases: The CADASIL Example: A Scientific Statement From the American Heart Association.
Neurology. Clinical practice, 2020 Dec
Treatment of migraine in patients with CADASIL: A systematic review and meta-analysis.
JAMA neurology, 2022 Jan 01
Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion.
Lancet (London, England), 2023 Mar 29
Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial.
Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2020 Feb 10
Infarct Core Reliability by CT Perfusion is a Time-Dependent Phenomenon.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019 Oct 26
Computed Tomography Angiogram Derived From Computed Tomography Perfusion Done with Low Iodine Volume Protocol Preserves Diagnostic Yield for Middle Cerebral Artery-M2 Occlusions.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022 Apr 14
CT Perfusion Maps Improve Detection of M2-MCA Occlusions in Acute Ischemic Stroke.
The Lancet. Neurology, 2021 Mar 17
Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.
The New England journal of medicine, 2024 May 16
Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage.
JAMA, 2024 Mar 05
Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis.
Stroke, 2024 May 15
Outcomes of Bridging Intravenous Thrombolysis Versus Endovascular Therapy Alone in Late-Window Acute Ischemic Stroke.
JAMA, 2022 May 10
Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.
Stroke, 2024 Feb 09
Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study.
JAMA neurology, 2019 Jun 01
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results.
The Lancet. Neurology, 2021 Mar 23
Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial.
Stroke, 2024 Feb 01
Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association.
JAMA neurology, 2021 Apr 01
Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke: The TOPMOST Study.
Stroke, 2023 May 24
Endovascular Versus Medical Management of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study.
Stroke, 2024 Jan 29
Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association.
Journal of child neurology, 2009 Dec
Ischemic perinatal stroke secondary to chorioamnionitis: a histopathological case presentation.
Virchows Archiv : an international journal of pathology, 2024 Mar 19
Perinatal arterial ischemic stroke: how informative is the placenta?
Stroke, 2007-12
Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.
The New England journal of medicine, 2006 Aug 10
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