Radiation Oncology

Cervical Cancer

Questions discussed in this category

How do you treat a locally advanced cervix cancer in a patient who declines brachytherapy?

What are your volumes and dose/fractionation for external beam boost in lieu of tandem and ovoid or tandem and ring implant?

8 Answers available

Do you recommend progesterone for endometrial protection in a young woman on estrogen replacement therapy for iatrogenic menopause after definitive radiation therapy for locally advanced cervical cancer?

If so, what do you typically prescribe?

2 Answers available

Would you offer post operative radiation for a patient who had findings of lymphovascular invasion on salvage resection of a recurrent obturator node after definitive chemoradiation for cervical cancer?

That nodal region has previously received 55 Gy in 25 fractions.

2 Answers available

How would you manage a cervical cancer patient with bulky PA LNs with direct extension and/or invasion into the lumbar vertebral bodies?

Would you consider this stage IVA (spread to adjacent organ) or IVB (spread to distant organ)? For instance, would the presence of direct lumbar verte...

4 Answers available

What are your top takeaways from SGO 2022?

10 Answers available

How would you manage a female in her 40s with stage III cervical cancer with hydronephrosis and Crohn's disease?

Would you consider standard definitive chemoRT (EBRT + HDR brachytherapy)?

3 Answers available

How do you manage a patient with cervical cancer who has FDG uptake in bilateral ischial tuberosities with lytic areas on CT correlate, and also has a history suspicious for untreated polymyalgia rheumatica with chronic symptoms in the same anatomic locations?

Cervical cancer FIGO stage IIIC2. Bloodwork shows elevated ESR and CRP.

4 Answers available

In light of the SHAPE trial results, how would you manage a patient with an incidentally diagnosed FIGO IA1 cervical cancer after simple extrafascial hysterectomy/BSO?

No LN dissection was performed as it was for a suspected CIN III. Final pathology showed +LVSI, -margins (>10mm), -parametrial extension, and 1.2mm...

2 Answers available

How would you manage a recurrent cervical cancer previously treated with vaginal cuff brachytherapy and has had a complete response to chemo-immunotherapy?

The 4 cm cuff recurrence occurred 3 years after definitive treatment with hysterectomy and vaginal cuff brachytherapy to 21 Gy. The recurrence had a c...

3 Answers available

Given the results of KEYNOTE-A18, do you plan to recommend adding pembrolizumab to primary chemoradiotherapy for advanced stage cervical cancer?

If so, will you recommend it universally or only for certain patient population(s)?

1 Answer available

What treatment would you offer a patient with metastatic cervical cancer to the supraclavicular nodes with a complete clinical response in her nodes, but a 3 cm residual in the cervix?

1 Answer available

Are there instances where you prefer an SBRT boost rather than a brachytherapy boost when treating definitive locally advanced cervical cancer?

If so, what dose/volume is prescribed? How do you account for motion?

2 Answers available

What are your top takeaways from SGO 2023?

7 Answers available

Will you be changing your management of locally advanced cervical cancer based on the results of the recently published INTERLACE trial?

3 Answers available

In a patient with previous cervix cancer treated with surgery and adjuvant EBRT who presents with recurrent HGSIL, status post vaginectomy, would you consider brachytherapy?

This is a patient in her 70s who previously received 5040 cGy adjuvant EBRT alone to the pelvis.

1 Answer available

Is there a role for chemotherapy and/or vaginal cuff boost to EBRT in FIGO IB1 cervical adenocarcinoma, status post total hysterectomy?

Aside from limit due to extent of her hysterectomy, the patient's disease does not otherwise satisfy Peters' criteria

5 Answers available

When treating stage IVB cervical cancer with both systemic chemotherapy and local pelvic radiation therapy, do you incorporate the use of bevacizumab as in GOG 240?

Consider treatment of stage IVB cervical cancer with systemic therapy and local pelvic radiation therapy as in Perkins et al., PMID 31810653.

2 Answers available

Do you have cut off values for neutrophil and platelet counts when doing interstitial brachytherapy for cervical cancer?

2 Answers available

How do you treat cervical cancer with an ovarian metastasis?

Considering this is stage IV disease, do your recommendations for definitive or adjuvant treatment (after surgery) change?

2 Answers available

What brachytherapy regimen would you use for a patient who completed only the EBRT portion of their planned definitive chemoradiation course for locally advanced cervical cancer, who is now presenting with persistent/recurrent local disease?

1 Answer available

What is the optimal approach for a younger female with borderline resectable cervix cancer who may need adjuvant radiation, in light of a medical history significant for ulcerative colitis?

MRI pelvis shows a 3.5 cm primary that appears infiltrative and without clear parametrial extension on MRI. Staging PET negative. Is there any ...

4 Answers available

What are your top takeaways in Gynecologic Cancers from ASCO 2023?

4 Answers available

When do you use a brachytherapy vaginal cuff boost in postoperative cervical cancer treatment?

Close but negative radial margins? LVSI? What fractionation/dose do you use for your vaginal cuff boost if used?

2 Answers available

What is your treatment approach for an adenoma malignum of the cervix?

7 cm tumor limited to the cervix with no vaginal or parametrial invasion on exam and not lymphadenopathy or metastatic disease on imaging. Cystoscopy ...

2 Answers available

How would you treat a woman who has had a simple, extrafascial hysterectomy for a clinically occult, pathologically FIGO stage IB1 cervical cancer?

Occult IB1 cervical SqCC found on simple extrafascial hysterectomy, with 4 mm deep stromal invasion and LVSI. Subsequent pelvic and para-aortic nodal ...

2 Answers available

What dose and OAR constraints you use for boost with IMRT or SBRT when a patient with cancer of the cervix is not candidate for brachytherapy?

Could you discuss how you decide between IMRT or SBRT boost for a patient who is not able to receive intracavitary or interstitial HDR or LDR brachyth...

1 Answer available

What is your approach for treating locally-advanced gastric-type adenocarcinoma of the cervix?

When would you use 5-fluorouracil instead of, or in addition to, cisplatin during chemoradiation? When, if ever, would you offer adjuvant hysterectomy...

5 Answers available

What is the longest interval to proceed with brachytherapy boost for cervical CA after EBRT?

Ideally, treatment should be completed in 56 days (preferably < 50 days). If there has been a significant delay to brachytherapy (>2-3 months) d...

2 Answers available

How would you treat a patient with synchronous locally advanced cervical and ovarian cancers?

1 Answer available

Would you offer brachytherapy for a patient with metastatic cervical cancer s/p 30Gy/10 fx to the pelvis followed by chemotherapy who only has isolated disease in the cervix?

If a patient presents with metastatic disease (by virtue of extensive PA nodal burden, mediastinal/SCV involvement, no solid organs) but received urge...

4 Answers available

For gyn cancers receiving chemoradiation, how high can you boost grossly positive nodes with SIB if not near bowel?

SIBs of 55-57.5 Gy in 25 fractions are frequently mentioned with bowel volume constraints at this dose, but assuming there is no bowel nearby (e.g., b...

4 Answers available

Would you give additional radiation for a positive margin after salvage hysterectomy for a patient with cervical cancer who had initial definitive chemoradiation with EBRT+T&R?

Would you consider additional EBRT or vaginal cuff HDR in a patient with previous tx with EBRT (45Gy) + HDR (30Gy) for a R1 resection with a radial ma...

2 Answers available

What is the role of uterine artery embolization (UAE) in patients with locally advanced cervical cancer with emergent bleeding that persists through vaginal packing?

What are the pros and cons of using uterine artery embolization with regard to how it may affect the efficacy of radiation (+/- chemotherapy)?

2 Answers available

How would you approach treatment for a locally advanced cervical cancer in the context of a completely prolapsed uterus in a non-surgical candidate?

1 Answer available

Would you modify standard WPRT+brachy radiation for cervical SCC s/p negative nodal staging but aborted hysterectomy due to previously undetected superficial vaginal disease?

1 Answer available

How would you treat an isolated para-aortic node recurrence 1.5 years after receiving primary chemoradiation for locally advanced cervical cancer?

4 Answers available

What type of DVT/PE prophylaxis do you employ for an outpatient cervical brachytherapy?

3 Answers available

How do you address extended break from EBRT during cervical cancer treatment?

Do you increase EBRT or brachy dose by a certain amount based on interval?

1 Answer available

What is your approach to a patient with locally advanced cervical cancer who presents with a fistula (rectal or bladder)?

Do you recommend upfront diversion? Are there unique planning considerations such as the inability to use bladder filling? How do you boost? What are ...

1 Answer available

How would you treat cervical stump SCC involving bladder, pelvic nodes, and port-site metastasis in a patient post-laparoscopic hysterectomy?

2 Answers available

For a patient with cervical cancer s/p chemoRT, would you consider brachytherapy to downstage tumor to allow for hysterectomy rather than pelvic exenteration?

1 Answer available

When do you transfuse cervical cancer patients undergoing chemoradiation?

Do you try to keep Hb> 10 or 12? Or somewhere in between?

2 Answers available

When do you consider re-irradiating patients with recurrent cervical cancer?

2 Answers available

What dose fractionation would you use on a large retroperitoneal recurrence of cervical cancer that is extending to previously treated 5040cGy pelvis?

1 Answer available

What is your strategy for treatment of FIGO IIB cervical cancer in a patient who poorly tolerated the first insertion and refuses subsequent insertions?

Patient is 38yo, has a history of narcotic abuse, and may have an undiagnosed personality disorder.

2 Answers available

What is your approach to a cervical cancer in a patient with a previous supra-cervical hysterectomy?

1 Answer available

What palliative regimen do you use for intra-pelvic recurrence of cervical cancer after definitive chemoRT with T&O brachytherapy?

Is the QuadShot a possible option?

1 Answer available

What is your institutional protocol for an incidental finding of an adnexal cyst on CT simulation for cervical cancer?

Could EBRT lead to rupture of the cyst?

2 Answers available

Would one expect any significant response of pulmonary metastases with usual dosage of weekly cisplatin during definitive chemoRT for cervical cancer?

This patient has pulmonary nodules that are too small to characterize.

1 Answer available

How would you manage a patient with 1B2 adenocarcinoma of the endocervix s/p TAH/BSO who was found to have bilateral metastasis to Fallopian tube, a 1 cm pelvic side wall metastasis, and no LN metastasis?

1 Answer available

In what scenario would you give consolidation chemotherapy after chemoradiation for stage 3 cervical cancer with a good response?

3 Answers available

Would you offer any adjuvant therapy for cervical cancer following total pelvic exenteration in the setting of a positive pelvic lymph node?

Previously received pelvic EBRT and intracavitary brachytherapy. IORT was administered to the node-positive side wall at the time of exenteration.

3 Answers available

What would be your treatment approach for a patient with a new PET positive para-aortic node 3 months following completion of definitive chemoradiation for locally advanced cervical cancer?

Patient did not previously receive para-aortic radiation. Considering RT vs RT + chemo vs chemo alone

1 Answer available

How would you approach treatment for centrally recurrent cervical SCC with positive margins after excision that was not exenteration?

Recurrence was 2cm and PET confirmed local. Excision with positive margins. Current plan for salvage whole pelvic RT and vaginal cuff brachytherapy +/...

3 Answers available

Do you add chemotherapy to salvage EBRT/brachytherapy for a pt with small vaginal cuff recurrence of cervical CA s/p hysterectomy?

2 Answers available

In cervical cancer, is the presence of parametrial LNs with ITCs considered parametrial disease requiring adjuvant chemo +/- RT?

In patient with PD SCCA 15mm transverse; 5/20mm invasion; LVSI focally present; margins negative; 0/15 Left pelvic and 0/14 right pe...

2 Answers available

How do you plan urgent radiation therapy for vaginal bleeding caused by locally advanced cervical cancer?

What dose and technique do you use and how do you integrate the subsequent definitive treatment plan?

2 Answers available

When would you consider sequential chemotherapy and radiation rather than concurrent for early stage cervical cancer with high risk pathologic features?

The recently released STARS phase 3 RCT found improved DFS, decreased distant recurrence, with reduced toxicities for chemotherapy (cisplatin + taxol)...

2 Answers available

How would you manage a cervical cancer patient who develops new oligomet to the spine during primary cis/RT?

How would you factor in a patient with profound thrombocytopenia?

3 Answers available

How would you approach radiation in a patient with IIIC2 SCC of the cervix with a history of ileoanal reanastomosis and j pouch?

Paraaortic nodes positive to left renal vein

1 Answer available

Would you offer definitive RT to a patient with metastatic cervical adenocarcinoma s/p carbo/taxol/avastin with a partial response in the metastatic sites?

ex. in a patient with pulmonary micronodules, inguinal, pelvic, PA nodes

3 Answers available

When can brachytherapy be used alone in the definitive treatment of FIGO IA1/IA2 medically inoperable cervical cancer?

1 Answer available

When do you include the mesorectum for definitive cervical cancer patients getting concurrent chemoradiation followed by brachy?

Particularly with IMRT when delineating volumes.

3 Answers available

How would you approach palliation of a symptomatic cervical cancer involving the supraclavicular lymph nodes?

Patient with stage IIB cervical cancer treated 8 years ago, now with large (>10cm), isolated, symptomatic recurrence involving the left SCL and med...

1 Answer available

How would you approach unresectable pelvic side wall recurrence in cervical cancer with previous definitive chemoradiation?

Would you consider SBRT or brachytherapy?

1 Answer available

Do you sample radiologically negative paraaortic nodes in cervical cancer patients with clinically positive pelvic nodes prior to initiating primary chemoradiation?

1 Answer available

What clinical factors would lead to utilizing a tandem and cylinder rather than tandem and ovoid for cervical cancer brachytherapy?

3 Answers available

How do you manage bladder fullness during cervical T&O brachytherapy to minimize OAR dose?

Small bowel is usually the dose limiting OAR while planning cervical HDR brachytherapy. Having the bladder empty during treatment planning and deliver...

2 Answers available

When, if ever, would you recommend hysterectomy after chemoradiation for patients with locally advanced cervical cancer?

This has been a common practice in the community. Is there a benefit for certain patients?

2 Answers available

Would you consider modifying T&O fractionation during the COVID-19 pandemic?

What dose/fractionation would you recommend?

2 Answers available

In what situations would you perform a sentinel lymph node biopsy for cervical cancer?

1 Answer available

For an non-operative patient with IB1 cervical cancer, would you recommend RT alone or concurrent chemoRT for definitive therapy?

2 Answers available

How would you manage a small posterior vaginal defect noted at the time of cervical brachytherapy?

Patient being treated for cervical cancer noted to have a < 1 cm posterior vaginal fornix defect with a small focus epiploclia herniating into the ...

2 Answers available

Would you consider a single insertion HDR scheme for T&O brachytherapy (BID fractionation over 3 days)?

Would there be a substanital increase in the risk of toxicity using such a scheme? We frequently have patients who have to travel long distance...

1 Answer available

How would you approach treatment for a primary carcinosarcoma of the cervix with pelvic and para-aortic nodal involvement?

What chemotherapy and sequencing with radiation therapy would you recommend? IS surgery a component of the treatment?

1 Answer available

In a pre-menopausal female with cervical cancer, would you boost a hypermetabolic ovary on PET?

Do you have an SUV cutoff for physiologic activity of the ovary?

1 Answer available

For stage IB1 cervical cancer s/p surgery with only 1 Sedlis criteria, should adjuvant pelvic EBRT or vaginal cuff brachytherapy be recommended in the presence of other adverse pathologic features, such as high tumor grade or very close but negative margins?

1 Answer available

Would you use different EBRT field edge for an HIV positive patient with FIGO IIIC1 (2018) cervical cancer with positive bilateral external iliac nodes?

Do you cover common iliac nodes (L3/L4) or keep field edge at L4/L5 to reduce bone marrow toxicity?

1 Answer available

Are you using the new FIGO 2018 staging or waiting until it is incorporated into the next AJCC edition?

4 Answers available

In light of the ongoing GOG 263 trial, do you consider adding concurrent chemo with RT for early stage cervical cancer as adjuvant after Rad Hyst off trial?

If so, what indications would you use other than Peters criteria?

1 Answer available

How do you define and IR-CTV for cervical brachytherapy?

Do you use a trimmed 10 mm expansion on HR-CTV? Do you also include the entire initial extent of disease? How much does your IR-CTV coverage affect yo...

1 Answer available

What volumes would you use for salvage radiation in a patient with a pelvic lymph node recurrence of cervical cancer initially treated with surgery alone?

What dose would you use?

1 Answer available

How do you match a para-aortic field to a previously irradiated whole pelvis field in a woman with PA nodal failure after definitive chemoRT for cervical cancer?

1 Answer available

How do you counsel a cervical cancer patient s/p definitive chemoRT who is not sexually active and refuses to use vaginal dilators to improve compliance?

2 Answers available

How would you treat an isolated port recurrence of an early stage cervical patient s/p WLE?

A literature search indicates that most port site recurrences are managed fairly aggressively with chemoRT or RT doses 45-66 Gy. This is understandabl...

1 Answer available

How do you sequence vaginal cuff brachytherapy with EBRT for post-op endometrial or cervical cases that require both modalities?

Sequentially or do you integrate the cuff brachy with the EBRT and if so what schedule, BIW, weekly, etc?

3 Answers available

How do you best manage bulky, clinical stage IIA squamous cell cancer of the cervical stump in a patient with a previous partial supra-cervical hysterectomy?

2 Answers available

Would you consider BID treatment for a patient with a pelvic SCC (e.g. cervix or anal) if a significant amount of treatment days have been missed?

For example, a patient with cervical or anal SCC who has missed many treatments due to side effects, low blood counts, hospitalizations, or non-compli...

1 Answer available

Do you take patients off anticoagulation for tandem and ovoid or tandem and ring procedures?

1 Answer available

What is your approach to a cervical SCC patient in which you're unable to properly place a T&O, due to obliterated cervical os, after completion of EBRT?

Do you add an IMRT boost with possibly vaginal brachytherapy?

2 Answers available

What is your protocol for conscious sedation during T&O insertion?

What are your specific protocols for monitoring and for dosing narcotics and sedatives?

2 Answers available

How would you approach the management of a patient with locally advanced cervical cancer as well as synchronous endometrial adenocarcinoma?

1 Answer available

What strategies have you found to be most helpful in improving patient compliance with vaginal dilator use after pelvic radiotherapy?

1 Answer available

What pelvic fields do you treat for patients with FIGO IA2-IB cervical cancer patients who inadvertently get a simple hysterectomy but with lymph node sampling (for presumed endometrial carcinoma)?

In the setting of a negative lymph node sampling, would you treat a full pelvis or mini-pelvis to compensate for lack of the appropriate surgery? Is a...

1 Answer available

Do you recommend adjuvant pelvic RT for Stage 1 cervical adenocarcinoma?

In patients who don't meet traditional criteria for adjuvant chemoradiation from Peters (GOG 109) and < 2 high risk factors from Rotman (GOG 92) fo...

1 Answer available

What is your technique to calculate the vaginal surface dose in gyn intracavitary brachytherapy?

What exactly do you contour and what is your dose constraint to that volume?

4 Answers available

What is the role of parametrial and pelvic side wall boosts in the setting of volumetric brachytherapy for locally advanced cervical cancer treated with either 3DCRT or IMRT?

Does using something like a vienna applicator allow you to avoid dose escalation with more external beam? How do you recommend doing a classic pa...

2 Answers available

What are you posterior field borders for endometrial and cervical cancer 3DCRT plans?

Some classic references recommend the coverage of the entirety of the sacrum but the volume delineation guidelines for both seem to only cover the mos...

1 Answer available

What is your strategy to deliver EBRT, brachytherapy, and a parametria/lymph node boost in less than 7-8 weeks for cervical cancer?

1 Answer available

What small bowel dose constraints do you use in gyn brachytherapy?

The most recent ABS guidelines don't discuss a dose constraint for the small bowel.

3 Answers available

If a patient with locally advanced cervical cancer cannot receive brachytherapy following 45Gy to the whole pelvis, how do you optimally deliver your boost?

Does your strategy change if bladder invasion is present?

1 Answer available

What indications do you use to prophylactically treat para-aortic lymph nodes in cervical cancer?

Do you treat PAs if pelvic nodes are positive? If common iliacs are involved? Only if there are positive PA nodes?

2 Answers available

What is the biggest mistake people make when using IMRT to treat cervical cancer?

1 Answer available

Papers discussed in this category

International journal of radiation oncology, biology, physics, 2011-02-01

Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer.

Int J Radiat Oncol Biol Phys, 2013 Jul 9

Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States.

JAMA Netw Open, 2021 Apr 01

Red Blood Cell Transfusion Practices for Patients With Cervical Cancer Undergoing Radiotherapy.

Int. J. Radiat. Oncol. Biol. Phys., 2014-05-01

Manifestation pattern of early-late vaginal morbidity after definitive radiation (chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: an analysis from the EMBRACE study.

Cancer Nurs, 2017-04-21

Dilator Use After Vaginal Brachytherapy for Endometrial Cancer: A Randomized Feasibility and Adherence Study.

Cochrane Database Syst Rev, 2010 Sep 08

Vaginal dilator therapy for women receiving pelvic radiotherapy.

International journal of radiation oncology, biology, physics, 2019-05-01

Single-Institution Experience in 3D MRI-Based Brachytherapy for Cervical Cancer for 239 Women: Can Dose Overcome Poor Response?

Cochrane Database Syst Rev, 2012 May 16

Radiotherapy and chemoradiation after surgery for early cervical cancer.

Int. J. Gynecol. Cancer,

Impact of the addition of concurrent chemotherapy to pelvic radiotherapy in surgically treated stage IB1-IIB cervical cancer patients with intermediate-risk or high-risk factors: a 13-year experience.

Seminars in radiation oncology, 2019-04

Management of Nodal Disease in Advanced Cervical Cancer.

International journal of radiation oncology, biology, physics, 2006-08-01

Influence of margin status and radiation on recurrence after radical hysterectomy in Stage IB cervical cancer.

Gynecologic oncology, 2005-11

Cervical sarcomas: an analysis of incidence and outcome.

J. Clin. Oncol., 2011 Mar 28

Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix.

BMC Cancer, 2017 Apr 28

Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk, early stage uterine cervical cancer patients after radical hysterectomy.

Clin Transl Radiat Oncol, 2018 Jan 11

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2019-01

Incidence of mesorectal node metastasis in locally advanced cervical cancer: its therapeutic implications.

International journal of radiation oncology, biology, physics, 1991-07

Radiotherapy alone for medically inoperable carcinoma of the cervix: stage IA and carcinoma in situ.

Cancer,

Results of treatment of early stage I carcinoma of the uterine cervix with intracavitary radium alone.

N. Engl. J. Med.,

Improved survival with bevacizumab in advanced cervical cancer.

J Gynecol Oncol,

Advances in diagnosis and treatment of metastatic cervical cancer.

International journal of radiation oncology, biology, physics, 2008-11-15

Prospective clinical trial of positron emission tomography/computed tomography image-guided intensity-modulated radiation therapy for cervical carcinoma with positive para-aortic lymph nodes.

Int. J. Radiat. Oncol. Biol. Phys., 2012 Aug 14

Curative chemoradiotherapy in patients with stage IVB cervical cancer presenting with paraortic and left supraclavicular lymph node metastases.

Practical radiation oncology, 2017

Impact of treatment year on survival and adverse effects in patients with cervical cancer and paraortic lymph node metastases treated with definitive extended-field radiation therapy.

Practical radiation oncology, 2018

Definitive local therapy is associated with improved overall survival in metastatic cervical cancer.

Radiother Oncol, 2020 Oct 14

Ureteral stenosis after 3D MRI-based brachytherapy for cervical cancer - Have we identified all the risk factors?

The New England journal of medicine, 1999-04-15

Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000-04

Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix.

Ann Oncol, 2012 Feb 21

A randomized phase III adjuvant study in high-risk cervical cancer: simultaneous radiochemotherapy with cisplatin (S-RC) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R): a NOGGO-AGO Intergroup Study.

JAMA Oncol,

Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.

Int J Gynecol Cancer, 2019 Jan 04

Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL Trial.

Gynecologic oncology, 1998-08

Radiation therapy of pelvic recurrence after radical hysterectomy for cervical carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-08-01

Phase III study of cisplatin with or without paclitaxel in stage IVB, recurrent, or persistent squamous cell carcinoma of the cervix: a gynecologic oncology group study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-10-01

Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985-08

Randomized trial of three cisplatin dose schedules in squamous-cell carcinoma of the cervix: a Gynecologic Oncology Group study.

Cancer, 1981-08-15

Cis-platinum in treatment of advanced or recurrent squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group.

Clin Transl Radiat Oncol, 2020 Apr 16

Long-term patient-reported distress in locally advanced cervical cancer patients treated with definitive chemoradiation.

Pract Radiat Oncol, 2019 Nov

Salvage Curative-Intent Reirradiation Stereotactic Body Radiation Therapy for Isolated Pelvic and/or Paraortic Recurrences of Gynecologic Malignancies.

Cancers (Basel), 2021 Mar 11

Image-Guided Brachytherapy for Salvage Reirradiation: A Systematic Review.

International journal of radiation oncology, biology, physics, 2017-12-01

Reirradiation Using Permanent Interstitial Brachytherapy: A Potentially Durable Technique for Salvaging Recurrent Pelvic Malignancies.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2017-03

Incidence of Venous Thromboembolism by Type of Gynecologic Malignancy and Surgical Modality in the National Surgical Quality Improvement Program.

N Engl J Med, 2021 Sep 18

Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer.

N Engl J Med, 2022 Jan 19

Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer.

Radiother Oncol, 2016 Sep

Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer.

JCO Glob Oncol,

Emergency Embolization of Pelvic Vessels in Patients With Locally Advanced Cervical Cancer and Massive Vaginal Bleeding: A Case Series in a Latin American Oncological Center.

Gynecologic oncology, 2003-06

Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: a randomized trial of the Gynecologic Oncology Group.

American journal of obstetrics and gynecology, 2007-11

Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: follow-up of a Gynecologic Oncology Group trial.

Gynecol Oncol, 2022 Oct 15

Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.

Am J Surg Pathol, 2015 Nov

Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis.

BMC Cancer, 2021 Oct 11

Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas.

Gynecol Oncol, 2019 Jan 29

Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.

Int J Gynecol Cancer, 2018 Jan

Chemoresistance of Gastric-Type Mucinous Carcinoma of the Uterine Cervix: A Study of the Sankai Gynecology Study Group.

BMB Rep, 2022 Sep

Untold story of human cervical cancers: HPV-negative cervical cancer.

J Gynecol Oncol, 2019 Sep 17

Completion hysterectomy after chemoradiotherapy for locally advanced adeno-type cervical carcinoma: updated survival outcomes and experience in post radiation surgery.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-03-01

Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer.

Clinical Medicine Insights. Oncology, 2022 Jun 24

Combination of Palliative Thoracic Radiotherapy With Bevacizumab for Stage IV Nonsquamous NSCLC: Is There Any Impact of Time Interval on Survival?

N Engl J Med, 2023 Mar 27

Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer.

N Engl J Med, 2023 Mar 27

Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer.

Int J Gynecol Cancer, 2021 Sep 07

ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer.

Gynecologic oncology, 2004-03

A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study.

The New England journal of medicine, 2018-11-15

Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer.

J Clin Oncol, 2023 Jan 30

Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study.

Gynecol Oncol, 2021 Sep

Beyond Sedlis-A novel histology-specific nomogram for predicting cervical cancer recurrence risk: An NRG/GOG ancillary analysis.

Rheumatology (Sunnyvale, Calif.), 2015 May 07

Polymyalgia Rheumatica and its Association with Cancer.

Annals of the rheumatic diseases, 2013 Jul 10

Is cancer associated with polymyalgia rheumatica? A cohort study in the General Practice Research Database.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2022 Mar

Neoadjuvant chemotherapy followed by surgery in cervical cancer: past, present and future.

International journal of radiation oncology, biology, physics, 2023 Jan 12

Overall Severe Morbidity After Chemo-Radiation Therapy and Magnetic Resonance Imaging-Guided Adaptive Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.

The Lancet. Oncology, 2023 Dec

Durvalumab versus placebo with chemoradiotherapy for locally advanced cervical cancer (CALLA): a randomised, double-blind, phase 3 trial.

The Lancet. Oncology, 2021 Apr

MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.

International journal of radiation oncology, biology, physics, 2024 Oct 23

Hormone Replacement Therapy in Patients with Gynecologic Cancer and Radiation-Induced Premature Ovarian Insufficiency.

Int J Radiat Oncol Biol Phys, 2020 Mar 1

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