Radiation Oncology

NCI-CCC Tumor Board Question   

These are questions being discussed by academics at NCI-Cancer Centers

Questions discussed in this category

In clinical practice, consolidation chemotherapy is sometimes used, though this was not implemented in the PACIFIC trial. https://www.ncbi.nlm.nih.go...

The EGFR subgroup appeared not have benefited as much as other patients in the publication. However, recently it was reported that the PACIFIC study m...

No other site of metastatic disease. It is unclear if this situation should be managed as two separate primaries or metastatic disease.

Do your recommendations differ if patients are pre or postmenopausal given the data?

Patients are understandably concerned about the risks and benefits of radiation to an oozing, bleeding, ulcerated breast.  

When would you favor delivering local therapy (e.g. SBRT) prior to systemic therapy?

Would you treat this as a locally advanced breast cancer and offer surgery, radiation, and systemic therapy? Does your management change depending on ...

These patients have been largely excluded from these trials.  What if the infection is well controlled?

This is in regards to the risk of secondary cancers after radiation therapy or cytotoxic chemotherapy (such as anthracyclines) in an immunosuppre...

Papers discussed in this category

Int J Radiat Oncol Biol Phys, 2012 Sep 10

Int J Radiat Oncol Biol Phys, 2011 May 1

Int J Radiat Oncol Biol Phys, 2011 Nov 1

Lancet, 2017-09-09

J Natl Cancer Inst, 2006 Dec 20

Med Sci Sports Exerc, 2010 Jul

J Clin Oncol, 2016 Feb 20

Curr Breast Cancer Rep, 2016-01-01

Crit Rev Food Sci Nutr, 2018 Apr 19


JAMA Oncol,

Breast Cancer, 2012 Apr 25

Ann. Surg. Oncol., 2018 May 17

Lancet Oncol., 2015 Sep 09

N. Engl. J. Med., 2018 Sep 25

N Engl J Med, 2017 Nov 16

J Clin Oncol, 2008 Dec 10