Radiation Oncology

NCI-CCC Tumor Board Question   

These are questions being discussed by academics at NCI-Cancer Centers

Questions discussed in this category


What clinicopathological features would need to be present for you to recommend adjuvant chemotherapy? Would you treat pT3 disease? Any specific histo...

Specifically, would you offer salvage radiation to a patient who underwent a prostatectomy with PLND and had a post-op PSA of 12 with pathology reveal...

Do you routinely offer post-operative adjuvant radiation in addition to chemotherapy?  Has data from the Lung ART trial presented at ESMO 2020 a...

The patient went straight to gastrectomy for clinical T1 gastric adenocarcinoma, but post-op was up-graded to T4 disease.   Both ARTIST and Inte...

Should staging and treatment decisions be made based on imaging alone?

Most trials establishing CRT as standard of care for IIIB NSCLC excluded patients with separate ipsilateral lung nodules given that they were categori...

In clinical practice, consolidation chemotherapy is sometimes used, though this was not implemented in the PACIFIC trial. https://www.ncbi.nlm.nih.go...

The EGFR subgroup appeared not have benefited as much as other patients in the publication. However, recently it was reported that the PACIFIC study m...

No other site of metastatic disease. It is unclear if this situation should be managed as two separate primaries or metastatic disease.

Do your recommendations differ if patients are pre or postmenopausal given the data?

Patients are understandably concerned about the risks and benefits of radiation to an oozing, bleeding, ulcerated breast.  

When would you favor delivering local therapy (e.g. SBRT) prior to systemic therapy?

Would you treat this as a locally advanced breast cancer and offer surgery, radiation, and systemic therapy? Does your management change depending on ...

These patients have been largely excluded from these trials.  What if the infection is well controlled?

This is in regards to the risk of secondary cancers after radiation therapy or cytotoxic chemotherapy (such as anthracyclines) in an immunosuppre...

How would the new data presented at ASCO GI 2021 from from Alliance A021501 influence your answer?


Papers discussed in this category


International journal of radiation oncology, biology, physics, 2013-03-15

International journal of radiation oncology, biology, physics, 2011-05-01

International journal of radiation oncology, biology, physics, 2011-11-01

Lancet, 2017-09-09

Journal of the National Cancer Institute, 2006-12-20

Medicine and science in sports and exercise, 2010-07

J Clin Oncol, 2016 Feb 20

Curr Breast Cancer Rep, 2016-01-01

Crit Rev Food Sci Nutr, 2018 Apr 19

JAMA, 2018-02-20

JAMA Oncol,

Breast Cancer, 2012 Apr 25

Annals of surgical oncology, 2018-10

Lancet Oncol., 2015 Sep 09

The New England journal of medicine, 2018-12-13

N Engl J Med, 2017 Nov 16

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-12-10

Lancet Oncol., 2020 Feb 14

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-07-01

The New England journal of medicine, 2001-09-06

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-12-10

N. Engl. J. Med., 2017-07-27

Ann. Oncol.,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005-02-01

JAMA Oncol,

Urology, 2001-08

The New England journal of medicine, 2017-07-27

JAMA Oncol, 2021 Feb 18

International journal of radiation oncology, biology, physics, 2018-10-01