Radiation Oncology

Brain Metastases   

Questions discussed in this category



Is there evidence that supports/refutes the safety of concurrent use?

How should they be prioritized? V10, V12, mean brain dose, prior WB radiation? To what extent should tumor coverage, conformality and homogeneity be c...

This has become standard practice at our institution for patients with a good performance status, with whole brain radiotherapy given after the comple...

Can SRS or whole brain radiotherapy be reserved for progression in these young, healthy patients?

Do you modify your dose/fractionation depending on the amount of prior intrathecal therapy?

There are solid data from Emory, Korea and others suggesting that is as effective as single fraction SRS but has less complications. 

The 2014 "Choosing Wisely" list, released this past September, includes the assertion that we should not "routinely add adjuvant whole brain radiation...

Some medical oncologists tend to hold anticoagulation in patients who develop brain metastases for fear of causing intracranial hemorrhage.  Is t...

What are the best options to treat a patient with brain metastasis confined to the posterior fossa if the patient is young, has a favorable cancer, gr...

Based on recent ASTRO data, what is your selection criteria and size cutoffs?

In patients with contraindications to receiving an MRI scan, are other imaging modalities sufficient to treat patients with SRS?

In a patient with multiple brain metastases from NSCLC, is this reasonable?

The most frequent argument against whole brain RT is debilitating toxicity. However, I am having a hard time finding the most evidence based data on h...

While the Duke randomized study found similar rates of control with 1mm v. 3mm margins and higher radionecrosis with 3mm, it did not look at treating ...

It is my impression that for brain metastases >3 cm it may be preferable to deliver fractionated SRT versus the RTOG dose of 15 Gy SRS, if WBRT is ...


Papers discussed in this category


Clinical oncology (Royal College of Radiologists (Great Britain)), 2007-09

Radiation oncology (London, England), 2014-01-03

N Engl J Med, 2007 Aug 16

J Clin Oncol, 1999 Jul

Lancet, 2015 Jan 3

International journal of radiation oncology, biology, physics, 2011-11-01

Int. J. Radiat. Oncol. Biol. Phys., 2006-09-01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-12

Lancet Oncol., 2017-05-01

The New England journal of medicine, 1999-08-12

BMC Cancer, 2015-08-15

Journal of cancer research and therapeutics, 2012

International journal of radiation oncology, biology, physics, 2012-05-01

Neurosurgery, 2013-10

Practical radiation oncology, 2015

J. Neurosurg., 2005-01-01

J Korean Neurosurg Soc, 2011-08-01

Radiat Oncol, 2014-07-08

BMC Cancer, 2015-03-04

Acta Neurochir (Wien), 2013-01-01

The Lancet. Oncology, 2009-11

JAMA, 1998 Nov 4

J Clin Oncol, 2011 Jan 10

Journal of neurosurgery, 2010-12

Lancet Oncol, 2014 Apr

J Neurosurg, 2014 Dec

Stereotactic and functional neurosurgery, 2017

Cancer treatment reviews, 2011-11

Neuro-oncology, 2013-10

International journal of radiation oncology, biology, physics, 2018-03-15

International journal of radiation oncology, biology, physics, 2016-06-01

Int. J. Radiat. Oncol. Biol. Phys.,

Radiat Oncol, 2015 May 27

International journal of radiation oncology, biology, physics, 2016-06-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01

The New England journal of medicine, 2016-11-10

The New England journal of medicine, 2018-01-11

N. Engl. J. Med.,

Blood, 2015-07-23

International journal of radiation oncology, biology, physics, 2016-06-01

Radiat Oncol, 2011-12-21

Medical physics, 2010-08

Neurosurgery, 2010-03

International journal of radiation oncology, biology, physics, 2010-01-01

Int. J. Radiat. Oncol. Biol. Phys., 2016-07-15

J Thorac Oncol, 2016 Oct 07

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-04-01

J. Natl. Cancer Inst.,

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017-10