Endometrial Cancer   

Questions discussed in this category

Given data from metastatic breast cancer trials that show benefit with continuing trastuzumab despite progression.

At our institution we often give 5.5 Gy x 4 fractions. There really does not appear to be a general consensus regarding timing. Interested in what oth...

VC brachy, pelvic RT, +/- chemo?  Does your management change if it is confined to the endometrium without myometrium invasion or if it is only ...

EBRT vs VB? She technically meets PORTEC2, but also meets GOG99 and GOG249 (for pelvic RT) and PORTEC4. NCCN recommends for IB grade 1 vaginal brachyt...

Is there any indication for ENI in early stage disease or in advanced stages, without pathologic confirmation or PET positivity or CT size criteria?

The patient was initially observed after radical hysterectomy due to young age, FIGO IA grade 2 disease. The patient had isolated, biopsy-proven vagi...

In women receiving HDR intracavitary brachytherapy to treat the vaginal cuff, how do you overcome the challenge of excess lateral vaginal tissue ("dog...

PET- CT before surgery visualised a tumor localised to the uterus and a PET positive 3 cm enlarged node at L3 level.  Final path: endometroid FI...

Planning carboplatin/taxol/trastuzumab. Cervical stromal invasion on path. Looking for pelvic vs brachy and timing with chemotherapy.

Tumor felt to be technically unresectable due to extensive cervical/parametrial involvement. ER/PR and HER2 testing are pending.

Tumor traverses the myometrium to focally involve the serosa; 1/6 sentinels with ITC and the rest negative. 

In the unfortunate setting where you cannot get an underinsured patient whose policy does not cover radiotherapy started on treatment without guarante...

Would you consider adjuvant chemotherapy, radiation therapy, hormone therapy, or surveillance?

Do you give cuff and chemo or pelvic CRT or chemo alone?

The patient has a history of pelvic radiation and progressed through first line carboplatin/taxol. She has had a partial response to pembro/lenvatinib...

Would you consider "neoadjuvant" hormonal therapy to shrink tumors and potentially make more amenable to complete cytoreduction at a later date? Woul...

This case involves an impressive ‘high volume’ vaginal recurrence and patient was not originally planned for adjuvant therapy. Concerned t...

Would you offer EBRT alone or EBRT with vaginal cuff brachytherapy after surgery and chemotherapy for stage III (T3N0) carcinosarcoma of the uterus? ...

For a patient with good response to immunotherapy (unable to receive chemotherapy due to kidney function, comorbidities) where previously avid LN have...

Since no data exists or is pending, and the two disease processes are similar, should we consider PARP inhibition in this setting? This is assumi...

http://abstracts.asco.org/199/AbstView_199_180760.html http://abstracts.asco.org/199/AbstView_199_187537.html  

How do you counsel a pre-menopausal female with endometrioid cancer desiring definitive RT with egg harvesting and IVF for fertility preservation inst...

Insurance authorization for protons is pending, but if the patient cannot have protons would you treat with standard fractionation to ~70Gy or conside...

NCCN recommends brachytherapy plus or minus pelvic RT for surgically staged Grade 1, Stage II patients, but these originally staged IIB patients were ...

For the management of stage II endometrial cancer, NCCN says pelvic RT and/or vaginal brachytherapy.   Do you ever add vaginal cuff boost to pelv...

MRI and cervical biopsy are negative for cervical involvement 

are there any positive or negative synergies from combined megestrol/RT treatment?

At what point would you introduce the discussion of weight management, whether for risk reduction or overall health?

The NCCN recommends either systemic therapy + brachytherapy or pelvic RT + brachy or brachy alone or observation. How do you decide among these option...

Given the recent press release regarding the update on the phase 3 soft tissue sarcoma study of LARTRUVO (olaratumab) showing no benefit to the combin...

Female in her 60s who had presented originally with well-differentiated endometrioid adeno clinically and radiographically involving bilateral paramet...

For a woman with complete resection of serous intraepithelial carcinoma of the endometrium, would you recommend adjuvant radiation or chemotherapy? Wh...

Current NCCN guidelines suggest that vaginal brachytherapy is optional, and there may be concern for over-treatment locally given competing risk of di...

In what situations is it appropriate to offer observation (rather than VBT) to patients with stage II endometrial carcinoma who have had a radical hys...

Would you approach this situation as synchronous primaries (eg. FIGO IA in both) or as a locally advanced endometrial cancer (FIGO IIIA)? What adjuva...

For example, in an otherwise intermediate risk localized endometrial cancer (Grade 2, FIGO IB)?

If the post-operative simulation films reveal a significant lymphocele secondary to pelvic lymph node sampling, is it imperative that the entire lymph...

The gyn oncs at my institution sometimes will not perform lymphadenectomy if biopsy indicates low risk disease. Would LVSI as sole adverse risk factor...

What exactly do you contour and what is your dose constraint to that volume?

Does using something like a vienna applicator allow you to avoid dose escalation with more external beam? How do you recommend doing a classic pa...

Some classic references recommend the coverage of the entirety of the sacrum but the volume delineation guidelines for both seem to only cover the mos...

Papers discussed in this category

Gynecologic oncology, 2004-03

Int. J. Radiat. Oncol. Biol. Phys., 2005-08-01

Int. J. Radiat. Oncol. Biol. Phys., 1990-02-01

Gynecologic oncology, 2003-12

Int. J. Radiat. Oncol. Biol. Phys., 2014-05-01

Brachytherapy, 2015

Gynecologic oncology, 2007-11

Eur. J. Cancer, 2008 Apr 02

J Clin Oncol,

Gynecologic oncology, 2018-10

Gynecologic oncology, 2014-11

Lancet, 2010-03-06

International journal of radiation oncology, biology, physics, 2018-08-01

Brachytherapy, 2019 Sep - Oct

Gynecologic oncology, 2009-10

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-01-01

Gynecologic oncology, 2013-10

Gynecologic oncology, 2013-01

Eur. J. Cancer, 2010 Jul 07

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-07-20

The New England journal of medicine, 2019-06-13

Lancet Oncol., 2019 Jul 22

Gynecol Oncol, 2019 Sep

Cancer Nurs, 2017-04-21

American journal of clinical oncology, 2018-08

Cancer, 1987-10-15

Gynecologic oncology, 2015-09

Brachytherapy, 2016 Nov - Dec

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014-10

Practical radiation oncology, 2017

Gynecologic oncology, 2018-08

International journal of radiation oncology, biology, physics, 2017-04-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-07-10

Gynecol Oncol, 2017 Aug

J Gynecol Oncol, 2015 Nov 23

Int J Gynaecol Obstet,

Int J Womens Health, 2017 May 02

Radiat Oncol, 2015 Feb 22

Obstet Gynecol,

Annals of surgical oncology, 2016-05

Gynecologic oncology, 2003-07

Obstetrics and gynecology, 2013-09

Lancet Oncol.,

Gynecol. Oncol., 2005 Dec 20

Int J Gynecol Cancer,

International journal of radiation oncology, biology, physics, 2014-03-15

Brachytherapy, 2015

Nature, 2013-05-02

Gynecologic oncology, 2019-09

F1000Res, 2019 Jun 12

Lancet Oncol., 2018 Feb 12

Lancet, 2019 Apr 11

Gynecologic oncology, 2001-10

Int. J. Gynecol. Pathol.,

Gynecol. Oncol., 2019 Sep 26

Gynecologic oncology, 2017-08

Am J Obstet Gynecol, 2016 Nov 18

Eur J Cancer, 2019 Jun 07

J Clin Med, 2020 Nov 28

Int J Gynecol Cancer, 2019 Dec 18

Gynecol Oncol, 2019 Jul 22

JAMA oncology, 2016-11-01

Gynecologic oncology, 2013-04

Lancet, 2008 Dec 16

J. Natl. Cancer Inst., 2008 Nov 25

Gynecologic oncology, 2019-04

J Gynecol Oncol,

Gynecol Oncol, 2020 Aug 15

Gynecologic oncology, 2009-10

Am J Obstet Gynecol, 2017 Dec 06


Journal of minimally invasive gynecology, 2016-02-01

Am J Obstet Gynecol, 2020 Jul 18

The Lancet. Oncology, 2017-03

International journal of radiation oncology, biology, physics, 2004-03-01

Gynecologic oncology, 2015-11

Gynecol Oncol, 2020 May 29

Cancer, 2017-03-01

Lancet Oncol, 2019 Mar 25

Gynecologic oncology, 2007-06

Int J Gynecol Cancer,

Gynecol Oncol Rep, 2020 Jan 30

World J Surg Oncol, 2017 Jan 10

Gynecologic oncology, 2012-10

Practical radiation oncology, 2019

Brachytherapy, 2019 Apr 17

Brachytherapy, 2019

Radiother Oncol, 2020 Nov 05

Brachytherapy, 2021 Mar 26

The American journal of surgical pathology, 2017-01

Histopathology, 2011 Mar 25

J Minim Invasive Gynecol, 2021 Feb 08

Gynecologic oncology, 2019-06

Gynecol Oncol, 2021 Mar 05

Brachytherapy, 2020 Dec 29

Brachytherapy, 2002

Gynecologic oncology, 2019-04

Gynecol Oncol, 2017 Jul 06

Cochrane Database Syst Rev, 2011 Jun 15

Gynecologic oncology, 2014-05

International journal of radiation oncology, biology, physics, 2017-12-01

Gynecologic oncology, 2019-03

Int J Gynecol Cancer,

The Lancet. Oncology, 2014-02

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-06-01

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2004

Arch Gynecol Obstet, 2009 Mar 21

Strahlenther Onkol, 2011 Nov 17

Gynecol Oncol Res Pract, 2016 Jun 17

Brachytherapy, 2012

The New England journal of medicine, 2018-11-15

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2001

Int J Gynecol Cancer, 2020 Aug 04

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-03-10

J Clin Oncol, 2019 Nov 04

J Clin Oncol, 2020 Mar 13

Int J Gynecol Cancer, 2020 Dec 18

N Engl J Med, 2022 Jan 19

Gynecol Oncol, 2020 Nov 05

N Engl J Med, 2021 Sep 18

International journal of radiation oncology, biology, physics, 2013-01-01

Cancer, 2009-05-15

Gynecologic oncology, 2018-05

Virchows Arch,