Medical Oncology

Neuro-Oncology   

Questions discussed in this category


Discussion of treatment options for midline low-grade glioma causing life-altering symptoms in a pregnant patient to avoid teratogenicity.

Guidelines do not provide strong guidance on who will benefit from temozolomide vs PCV or when to consider re-challenging with temozolomide.

Would you suspect progressive disease v. radiation necrosis vs optic neuritis due to immunotherapy. Eyes were within radiation field 8 months ago.&nbs...

Specifically, how do you explain potential cognitive decline in a way that explains what changes they can expect in their daily lives?

NCCN lists PCV as category 1 (and now with analysis in Abstract 2002 from ASCO 2019 showing benefit in IDH mutated), and temozolomide as 2B, yet temoz...

Do you prefer WBRT, IT chemo or targeted systemic therapy and what is your preference on the sequence of therapies?

This has become standard practice at our institution for patients with a good performance status, with whole brain radiotherapy given after the comple...

Can SRS or whole brain radiotherapy be reserved for progression in these young, healthy patients?

For a lesion that appears radiographically consistent with a high grade glioma, would you treat empirically if there is hesitancy to perform a high ri...

If choosing systemic therapy, do you prefer bevacizumab with or without irinotecan? Have you used anti-PD1 agents (e.g. nivolumab) off label? 

Is there data related to types of metastases (tumor histology, anatomic distribution, hemorrhagic, diffuse, size, edema etc.) and risk for seizure?&nb...

Some medical oncologists tend to hold anticoagulation in patients who develop brain metastases for fear of causing intracranial hemorrhage.  Is t...

In particular, would you offer memantine to those with WHO II or III gliomas and a good performance status but larger treatment volume?

The Phase III J-ALEX study and two phase II studies seem to suggest favorable intracranial response rates for alectinib. 

Do you have a preference for specific steroids? Some practices may switch to prednisone during this time.   Patients with gliomas are often on d...

Do you really feel the failure was because people crossed over to bev at progression, or is it simply that bev does not affect overall survival?


Papers discussed in this category


Proceedings of the National Academy of Sciences of the United States of America, 2011-03-15

N Engl J Med, 2007 Aug 16

J Clin Oncol, 1999 Jul

Lancet, 2015 Jan 3

International journal of radiation oncology, biology, physics, 2011-11-01

Int. J. Radiat. Oncol. Biol. Phys., 2006-09-01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-12

Lancet Oncol., 2017-05-01

The New England journal of medicine, 1999-08-12

BMC Cancer, 2015-08-15

Journal of cancer research and therapeutics, 2012

International journal of radiation oncology, biology, physics, 2012-05-01

Neurosurgery, 2013-10

Practical radiation oncology, 2015

J. Neurosurg., 2005-01-01

J Korean Neurosurg Soc, 2011-08-01

Radiat Oncol, 2014-07-08

BMC Cancer, 2015-03-04

Acta Neurochir (Wien), 2013-01-01

International journal of radiation oncology, biology, physics, 2018-03-15

International journal of radiation oncology, biology, physics, 2016-06-01

Int. J. Radiat. Oncol. Biol. Phys.,

Radiat Oncol, 2015 May 27

International journal of radiation oncology, biology, physics, 2016-06-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01

The New England journal of medicine, 2016-11-10

The New England journal of medicine, 2018-01-11

N. Engl. J. Med.,

Blood, 2015-07-23

Neuro-oncology, 2013-10

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-09-01

Eur J Cancer, 2012 Sep

Anticancer Res.,

Int. J. Cancer, 2016 Jun 30

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-01-20

The New England journal of medicine, 2005-03-10

The New England journal of medicine, 2016-04-07

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999-09

Future Oncol, 2018 May 09

J Thorac Oncol, 2019 Feb 16

J Clin Oncol, 2011 Jan 10

JAMA, 2016-07-26

The Lancet. Oncology, 2017-08

The Lancet. Oncology, 2016-07

Int. J. Radiat. Oncol. Biol. Phys., 2019 Aug 31

Lung Cancer, 2019 Jan 15

The New England journal of medicine, 2018-08-23

JAMA oncology, 2017-06-01

Neuro-oncology, 2019-02-23

N. Engl. J. Med., 2019 Dec 11

J. Neurosurg., 2017 Mar 03

Acta Neurochir (Wien), 2019 Jan 29

J. Neurooncol., 2018 Apr 06