Radiation Oncology

Stereotactic Body Radiotherapy   

Questions discussed in this category



When is SBRT appropriate? Do you approach dose and fractionation differently in this setting?ƒ

What fractionation scheme would you use?  Would you give SBRT to a hilar tumor that has N1 nodal involvement adjacent to the tumor but can be enc...

Are pre-treatment PFTs actually correlated with treatment-related toxicity? If no absolute cutoff, do you have an ideal lower limit for PFTs...

Would you consider SBRT and if so what dose/fractionation would you use if the lesion was in the head of the mandibula? If not would you give a fract...

For that occasional "single lymph node metastasis" referral in patients with no other sites of disease, is there a therapeutic dose below which you're...

Does tumor location play a role (central vs peripheral) in making the decision?  The question stems from an oral presentation at ASTRO 2014 inves...

Would you alter your SBRT dose? How long would you hold the VEGF inhibitor before and after? Does the primary matter (e.g. NSCLC vs. colorectal)?

Would this location be adequate for SABR, if so what dose scheduling would be recommended?

For example in a patient with a good performance status and a biologically favorable cancer (ER+ breast cancer, EGFR+ NSCLC, or prostate cancer), are ...

Is there a benefit to one fractionation schedule v. the other?

For example, would you modify your SBRT dose next to the azygous vein? While we talk frequently about OAR constraints for the great vessels, it seems ...

I am treating a left lower lobe NSCLC and my PTV is so close to the spleen that a small portion of the spleen is getting significant dose.  I can...

Would you consider treating 3-5mm lesions with SBRT or wait until they are a certain size? I am concerned I will not be able to see them adequately on...

I see the LungTECH trial dose constraints, but, they seem really conservative when you have something large and close the PBT resulting in use of 60 G...

There seem to be a lot of different fractionation schemes in the literature. Is there one that is most standard?

Do you prefer breath-hold techniques (ABC, DIBH) or abdominal compression regardless of tumor motion? Or do you use a general threshold number of cc's...

The Indiana report and RTOG published a "danger zone".  There was a catastrophic "case report" for 50 Gy in 5 fractions.  Are there alternat...

Is there a dose response relationship, as suggested in the phase I MSKCC dose escalation study presented at ASTRO 2017?

In a patient with a cavitated lesion with underlying chronic infection (identified as cocci) and SqCC, are there additional risks to SBRT? Should spec...

In patients with aberrant anatomy due to previous surgery with lung PTV overlapping the stomach, how much would you dose de-escalate? Even conventiona...

Do you discuss this at the first consultation? Is there strong evidence to suggest that risks are significantly increased compared to upfront lobectom...

Is local control worse for SBRT when the tumor is invading into the bone (rib)?

Specifically in O2-dependent patients? Have any dose/fractionation regimens been shown to reduce the risk of pneumonitis in this population?

Aside from steroids and PT, is there anecdotal evidence for warfarin, hyperbaric oxygen, bevacizumab etc. Any experience with these therapies?

For example, a NSCLC of the LLL abutting and potentially involving the adventitia of the descending aorta?

In a patient with pain that does not respond well to narcotics what would be your treatment approach?  Is there any data that suggests patients c...

Is the dose fractionation used in BR-001 (10Gyx3) appropriate for all osseous locations, for example humeral head metastases?

If so, 50 Gy / 5 fx? 7.5 Gy / 8 fx? If so what dose constraints would you use to help determine fractionation?

Does fractionation (or location) influence this decision? What is your preferred steroid dose?

Is there a role for SBRT to the primary site? Is it required to treat the ipsilateral hilum if no adenopathy was seen on EBUS or PET?

Given the multiple retrospective studies showing benefit to higher BED fractionation schedules (most recently, http://www.redjournal.org/article/S0360...

Given the lepidic growth pattern, do you use similar margins as with frankly invasive lung tumors? Are there any challenges localizing the target with...

When treating lung tumors abutting the visceral pleura/chest wall with SBRT, chest wall or rib pain sometimes occurs. In these cases, I try to avoid i...

If given options of liver, lung, spine, brain, axilla, or other lymph nodes which sites do you pick?

Any special dosing considerations or can you approach this like any other small peripheral NSCLC?

Which imaging studies do you perform and what is the timing after treatment?

Does your volume change based on fractionation (high-dose single fraction vs. 3-5 fractions)? Do you treat the entire circumference of long bones? Wha...

Are there specific conformality parameters you prioritize (105% dose volume outside of PTV, conformality index, ratio of 50% isodose volume to PTV, an...

Recently, while planning a patient for lung SBRT it was suggested by the physicist that we change the density of the PTV to higher density to improve ...

Have you ever seen toxicity related to diaphragm dose with conventional fractionation?  

And at what intervals? The published trials/RTOG call for q3 month MRI follow-up. Is this appropriate outside a clinical trial setting? 

If surgical stabilization has been performed, do you go with SBRT dosing? If so, do you treat only the involved site and not the extent of hardware? D...

What is the average healing time? What medications and/or procedures do you recommend for pain control? Does management differ for those with chest wa...

Do you specify an isodose line to prescribe to? Do you ask for a percent hot, and if so do you specify what percent or volume of the GTV/ITV should re...

Under what clinical circumstances would you consider prescribing them?

If a biopsy carries a high risk of morbidity what interventions would you recommend for the local failure?

In my training, we used an abdominal compression paddle, but in my current practice, my physicist says that we cannot treat through multiple parts of ...

As it is suggested for larger tumors treated with surgery, based on post hoc CALGB analysis?

In starting prostate SBRT at an instutution, what are issues with the treatment that one should pay special attention to?

If so what dose-fractionation do you use and what constraints for brachial plexus?

In treating an oligometastatic lesion in the sacrum, is it reasonable to extrapolate from RTOG brachial plexus contraints (eg, 8 Gy/fx for a 3-fractio...

In other words, if offered wedge or segmentectomy, should SBRT be preferred? Does size matter ie if the lesion is < 3 vs < 2 vs < 1 cm? Does ...

The BED10 for 50 Gy in 5 fractions is 100, which is significantly lower then the BED of the 54 Gy in 3 fractions regimen (151). Since the Kestin/Grill...

Our dosimetrists rarely meet the RTOG constraint using a non-coplanar technique, especially for very small lesions. I haven't been able to find a corr...

What factors should be considered with offering SBRT to oligometastatic bone disease in prostate cancer patients? Should this been done off of a proto...

Any advice on how to safely incorporate it into our practice?

Would you consider placing a stent in this patent graft to minimize closure of the graft after SBRT?

Is there any concern about hemorrhage from treatment effect on tumor? Would SABR worsen the chance of fatal hemorrhage/hemoptysis and if so, would you...

For small overall volumes (e.g. 0.5cm solid component, 1cm total lesion size when including GGO), I imagine treating the entirety of the abnormality i...

ASTRO 2014's lung session presented data from RTOG 0236, showing a 20% intralobar failure/recurrence despite only 7% local failure. How does one recon...

RTOG 0915 allows either technique, but I've heard people say that IMRT is not "technically" SBRT. Is there is a benefit to the non-coplanar 3D techniq...

In SBRT, it has been said that Pencil Beam dose calculation algorithm can overestimate the target dose and understimate the normal tiss...

What dose/fractionation is appropriate and does it differ between histology?

What are the primary data that drove organ at risk and conformality dose constraints?  


Papers discussed in this category


J Thorac Oncol, 2007 Jul

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014-03

Int J Radiat Oncol Biol Phys, 2002 Mar 15

Radiat Oncol, 2007 Jun 7

International journal of radiation oncology, biology, physics, 2012-02-01

JAMA, 2010-03-17

The Lancet. Oncology, 2015-02

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2009-07

International journal of radiation oncology, biology, physics, 2008-10-01

Cancers (Basel), 2018 Aug 02

The New England journal of medicine, 2012-06-14

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-10-20

International journal of radiation oncology, biology, physics, 2012-08-01

International journal of radiation oncology, biology, physics, 2014-07-01

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2009-06

J Thorac Oncol, 2011 Dec

International journal of radiation oncology, biology, physics, 2013-08-01

Radiother Oncol, 2011 Nov

International journal of radiation oncology, biology, physics, 2010-03-01

The Journal of thoracic and cardiovascular surgery, 2013-03

Medical physics, 2013-09

International journal of radiation oncology, biology, physics, 2010-06-01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2009-08

International journal of radiation oncology, biology, physics, 2007-10-01

Int J Radiat Oncol Biol Phys, 2000 Nov 1

Sarcoma, 2013

Cancer, 1998 Mar 15

International journal of radiation oncology, biology, physics, 2012-11-01

International journal of radiation oncology, biology, physics, 2017-03-15

International journal of radiation oncology, biology, physics, 2015-11-15

Radiother Oncol, 2013 Aug

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016-10

International journal of radiation oncology, biology, physics, 2016-12-01

Practical radiation oncology, 2018

Radiation oncology (London, England), 2013-01-03

Cancer, 2007-11-15

Cancer, 2015-04-01

JAMA, 2012 Jul 11

JAMA, 2008-03-05

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-07-20

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-08-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-07-20

International journal of radiation oncology, biology, physics, 2011-09-01

American journal of clinical oncology, 2011-02

International journal of radiation oncology, biology, physics, 2013-12-01

JAMA, 2007 Jan 17

Cancer, 1987 Jun 15

Ann Surg, 2007 Nov

International journal of radiation oncology, biology, physics, 2014-12-01

International journal of radiation oncology, biology, physics, 2014-04-01

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2009-12

International journal of radiation oncology, biology, physics, 2012-10-01

Medical physics, 2010-08

International journal of radiation oncology, biology, physics, 2015-06-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-01-10

J Natl Cancer Inst, 2014 Aug

Frontiers in oncology, 2011

Eur Urol, 2015 Jul 16

BJU Int, 2009 Feb

European urology, 2014-06

Int J Radiat Oncol Biol Phys, 2008 Oct 1

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-01-20

Technology in cancer research & treatment, 2014-06

The Lancet. Oncology, 2015-06

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-11-01

Semin Radiat Oncol, 2015 Oct

Journal of applied clinical medical physics, 2010-08-19

Technology in cancer research & treatment, 2016-02

International journal of radiation oncology, biology, physics, 2012-01-01

The Lancet. Oncology, 2015-12

International journal of radiation oncology, biology, physics, 2010-12-01

Frontiers in oncology, 2014

Radiother Oncol, 2013 Oct

International journal of radiation oncology, biology, physics, 2016-09-01

Radiother Oncol, 2012 Mar

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-12-01

The Lancet. Oncology, 2016-12

International journal of radiation oncology, biology, physics, 2015-09-01

J Thorac Oncol, 2016-07-01

The British journal of radiology, 2016

Int. J. Radiat. Oncol. Biol. Phys., 2006-02-01

International journal of radiation oncology, biology, physics, 2009-02-01

N Engl J Med, 2007 Aug 16

Lancet, 2015 Jan 3

Clin Lung Cancer, 2011-11-01

International journal of radiation oncology, biology, physics, 2016-08-01

Hematology/oncology clinics of North America, 2006-02

Practical radiation oncology, 2014

Ann Palliat Med, 2016 Jan

Clin Oncol (R Coll Radiol), 2015-05-01

Cancer, 2010-05-01

Journal of pain and symptom management, 2008-03

Lancet (London, England), 2005

Frontiers in oncology, 2017

International journal of radiation oncology, biology, physics, 2008-09-01

International journal of radiation oncology, biology, physics, 2014-11-15

Int J Radiat Oncol Biol Phys, 2009 Sep 1

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-04-01

Acta Oncol, 2006-01-01

J. Cancer Res. Clin. Oncol., 2015-07-01

Semin Radiat Oncol, 2017-07-01

N Engl J Med, 2017 Nov 16

International journal of radiation oncology, biology, physics, 2008-04-01

International journal of radiation oncology, biology, physics, 2016-07-01

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2013-11

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-05-20

Frontiers of radiation therapy and oncology, 2011

Int. J. Radiat. Oncol. Biol. Phys.,

International journal of radiation oncology, biology, physics, 2009-04-01

Journal of neurosurgery. Spine, 2012-07

International journal of radiation oncology, biology, physics, 2010-06-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-09-20

Future oncology (London, England), 2015

Future Oncol, 2015 Oct 15

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-10-20

International journal of radiation oncology, biology, physics, 2014-09-01

Clinical lung cancer, 2016-11

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014-08

International journal of radiation oncology, biology, physics, 2013-01-01

Annals of surgical oncology, 2002-07

International journal of radiation oncology, biology, physics, 1992

Clin Oncol (R Coll Radiol),

Clin Lung Cancer, 2017 Jul 10

J Thorac Oncol,

Clinical lung cancer, 2018-07

Int. J. Radiat. Oncol. Biol. Phys., 2017 Mar 15

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016-06

Practical radiation oncology, 2018

Practical radiation oncology, 2018

Medical physics, 2011-11

Clin Lung Cancer, 2017 Mar

International journal of radiation oncology, biology, physics, 2013-04-01

N. Engl. J. Med.,

PLoS ONE, 2015 Nov 24

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-20

Lancet, 2019 Apr 11

Cancer, 2011-09-01

International journal of radiation oncology, biology, physics, 2015-07-01

Cancer treatment reviews, 2017-02

Strahlenther Onkol, 2019 Feb 08

Radiother Oncol, 2018 Jul 09

Clin Oncol (R Coll Radiol), 2017 Oct 13

European urology focus, 2019-11

Adv Radiat Oncol, 2017 Nov 22

BMC Cancer, 2019 Aug 19