Pediatric Oncology

Hematologic Malignancies   

Questions discussed in this category


There are conflicting reports whether it contributes to renal insufficiency. If you do switch, what is your preferred TKI in this scenario?

How would the risk of VTE associated with crizotinib affect your decision? Should we consider using crizotinib in combination with brentuximab?

What are the differences in approach to B lymphoid/myeloid and T lymphoid/myeloid MPAL?

What is the role of PD-1 inhibitors after CAR-T infusion, either as maintenance therapy or in the setting of relapsed disease? 

iPET2 and iPET4 showed Deauville 5 response. CT biopsy after 4 cycles was negative. Patient is currently scheduled for 2 additional cycles of ABVD.

Do you use a cutoff of 10 cm? Do you measure the size of the largest node or measure the largest conglomerate or measure the total length of the entir...

How does graft function play into your decision making? How do you utilize post allogeneic transplant chimerism in clinical practice? Do you obta...

Given the POLARIX study data presented at ASH 2021, will this replace R-CHOP as the standard of care therapy in your practice? If not, how will y...

How does belumosudil now fit in your approach to steroid refractory chronic graft-versus-host disease?

For patients not on study, would you consider replacing missed doses of peg with a non-asparaginase based chemotherapy?

Is an LP only recommended in the setting of particular subtypes of lymphoma or symptoms of CNS disease?

Do your recommendations differ between those who receive ABVD and escalated BEACOPP? Do you recommend consultation with fertility specialists for all...

Would this change with someone who has a history of thrombosis (e.g. DVT/PE, MI, CVA)? Would this change with someone who is more fit vs more frail?

Results of AHOD1331 are not yet known, but adults have started using Brentuximab upfront for high risk patients  

If given both options, which donor would one prefer: haploidentical related donor or 7/8 mismatched unrelated donor using post transplant cyclophospha...

It used to be a contraindication for G-CSF use for AML patients, but currently, several protocols include it to decrease neutropenic duration.

Would you use ALK inhibitors such as crizotinib based on recent phase II data? Are there any research efforts to combine ALK inhibitors with current ...

Do you always treat with the full 21-day treatment course, or can defibrotide be stopped if certain criteria are met sooner?

Do you prefer a cHL chemotherapy backbone or PMBL chemotherapy backbone?

Specifically, are there strategies you use to 1) empower patients to participate in decision-making and 2) reassure patients who may be skeptical?

With the new COG leukemia studies, it is difficult to interpret these results in the context of their clinical status and conventional MRD 

Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?

At what age would you treat an early stage hodgkins lymphoma patient with ABVD + RT (adult treatment) vs OEPA x 2 or AV-PC x 3 (pediatric paradigm)?&n...

Guidelines indicate RCHOPx3 +RT as category I and RCHOP x 6 below that; long term f/u for SWOG 8736 showed similar PFS and OS. Do you have and approac...

We often see young women with favorable, early stage disease in the mediastinum who have had a complete response to chemotherapy. With current smaller...

After ABVE-PC X4 and Ifos/vinorelbine x 2 per AHOD 0831 (and is unable to have these sites biopsied), what dose would you treat to and what volume wou...

It seems that with the arms up, you get better lung blocking but with arms akimbo, you might have a lower dose to the humeral head. 


Papers discussed in this category


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-11-10

Practical radiation oncology, 2015

Cancer, 2004-08-15

Br. J. Haematol., 2003-11-01

Br. J. Haematol., 1998-08-01

Cancer, 1990-11-15

Radiother Oncol, 1990-01-01

Int. J. Radiat. Oncol. Biol. Phys., 2017-01-01

Cancer, 1994-01-01

Med. Pediatr. Oncol.,

Arch. Dis. Child.,

Pediatric blood & cancer, 2018-05

Br. J. Haematol.,

Fertil. Steril., 2013 Sep 05

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-09-01

Blood,

J. Clin. Oncol., 2019 Sep 10

American journal of hematology, 2018-08

Blood, 2019-04-04

Am. J. Hematol., 2019 Nov 19

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-07-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-03-20

J. Clin. Oncol.,

The New England journal of medicine, 2007-01-25

Haematologica, 2020

Nature, 2019-03

Blood, 2018 May 02

Leuk Lymphoma, 2019 Dec 26

, 2016 Apr 26

American journal of clinical oncology, 1992-10

Clin Lymphoma Myeloma Leuk, 2017 Mar 07

The journal of allergy and clinical immunology. In practice, 2017

Blood, 2020 Sep 23

Blood, 2009-09-03

J Clin Oncol, 2020 Apr 28

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-08-20

J Clin Oncol, 2019 Oct 14

American journal of hematology, 2019-04

N. Engl. J. Med., 2018-01-25

Bone Marrow Transplant, 2019 Oct 01

Front Immunol, 2020 Apr 03

Biol. Blood Marrow Transplant., 2019 Aug 22

Bone Marrow Transplant, 2018 Nov 01

Biol Blood Marrow Transplant, 2019 Aug 21

J Clin Oncol,

Blood, 2021 Mar 08

J Clin Oncol, 2021 Apr 07

Biol Blood Marrow Transplant, 2019 Jul 01

Ann Hematol, 2015 Mar 27

Leukemia, 2008-12

Blood, 2013-05-02

Cochrane Database Syst Rev, 2012 Jun 13

N Engl J Med,

Blood, 2006 Sep 28

J Clin Oncol, 2010 Apr 20

J Clin Oncol,

Cancer chemotherapy and pharmacology, 2017-01

Ann Oncol, 2021 Mar 18

Clin Transl Oncol, 2020 Sep 17

J Assist Reprod Genet, 2020 Jun 02

Lancet Oncol, 2018 Sep 13

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-02-20

Lancet (London, England), 2010-12-11

Blood, 2012 Apr 04

Clin Lymphoma Myeloma Leuk, 2019 Sep 30

Bone Marrow Transplant, 2018 Jun 08

J Clin Oncol, 2020 Apr 10

The Lancet. Oncology, 2017-09

Transplant Cell Ther, 2021 Sep 02

Blood Adv,

Front Oncol, 2021 Mar 25

Regen Ther, 2020 May 15

British journal of haematology, 2014-06

International journal of radiation oncology, biology, physics, 2019-06-01

Annals of oncology : official journal of the European Society for Medical Oncology, 2007-04

Blood, 2018-07-05

Blood,

Blood,

J Clin Oncol, 2021 Jun 25

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009-10

Journal of pediatric hematology/oncology, 2019-08

Lancet, 2012 Apr 04

Blood, 2018 Aug 30

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-09-20

Blood, 2016-11-24

British journal of haematology, 2008-06

Leukemia, 2021 May 03

N Engl J Med,

Blood, 2008-02-15

Blood, 2016-07-28

Blood advances, 2016-12-27

The Lancet. Haematology, 2018-12

N Engl J Med,

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2015-04

Pediatr Blood Cancer, 2019 Jul 31

J Clin Oncol, 2021 Dec 9

Blood Cancer Discov, 2021 Dec 01

Pharmacogenomics,

Pediatr Blood Cancer, 2011 Feb 22

Pediatr Blood Cancer, 2011 Jul 27

Int J Hematol, 2021 Oct 28

Pharmacogenet Genomics,

Ann Oncol,

Journal of hospital medicine, 2018-08-01

Front Oncol, 2022 Mar 09

BMJ Support Palliat Care, 2022 Jul 08

Nutr Cancer, 2019 Oct 12

Annals of oncology : official journal of the European Society for Medical Oncology, 1993-11

Exp Hematol Oncol, 2021 Feb 19

Oncotarget,

The Lancet. Haematology, 2019-03

J Clin Oncol, 2021 Dec 02

Urology, 1982-09

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009-03

Clin Infect Dis, 2005 Jan 21

Pediatr Transplant, 2014 Sep 08

J Clin Oncol, 2021 Apr 30

Pediatr Infect Dis J, 2014 Nov

Bone Marrow Transplant, 2006 Mar

Blood, 2006-05-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-02-01

Blood, 2017-03-09

The Lancet. Oncology, 2015-10

N Engl J Med, 2013 Jul 11

Blood, 2012 Jun 19

Blood, 2019-04-11

N Engl J Med, 2022 Dec 11

Pediatr Blood Cancer, 2021 Oct

J Clin Pharmacol, 2021 Jul 16

J Clin Oncol, 2022 Dec 19