Pediatric Oncology

Benign Hematology   

Questions discussed in this category


While L-glutamine has minimal side effects and would likely be added after hydrea, how do you decide between the use of voxelotor and crizanlizumab?

In the absence of concerning bleeding or thrombosis, family history of coagulopathy, current anticoagulant use, or malnutrition

What would you recommend within the first year after ATG and thereafter if still maintained on cyclosporine?

Ferritin uptrending >1000, no additional lab abnormalities. HFE wildtype. Too young for age-appropriate cancer screening. Asymptomatic except fatig...

If hydroxyurea modifies the course of sickle cell disease by increasing fetal hemoglobin, is there any benefit to using it in patients with fetal hemo...

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

Patient with high titer acquired FVIII inhibitor with no causative etiology.  Bleeding is well-controlled on emicizumab, but inhibitor has failed...

The patient has no personal history of VTE, but has positive family history of VTE.  Any prophylactic anticoagulation options? How would manage...

For instance, if clonal hematopoiesis of indeterminate potential (CHIP) suspected 

I.e., what constitutes well-controlled cancer, IBD, nephrotic syndrome, etc. What other diseases do you put in this category (obesity, autoimmune dise...

If so, what platelet count threshold would you use? Would age impact your decision? Would you do a bone marrow to rule out primary MPD in adults if th...

Should we stop checking factor VIII levels as part of thrombosis workup?

How would the approach differ if the patient had a significant bleeding phenotype vs only minor bruising and mucosal bleeding?

FVL heterozygotes are often treated similarly to the general population. Aside from avoiding other VTE risk factors, are there situations where prophy...

Such as the case in which a patient is unresponsive to steroids, IVIG, TPO-agonist, rituximab, splenectomy, and even fostamitinib.

Also is there value in using voxelotor for the purpose of reducing hemolysis, and if so what parameters do you use to determine when to initiate voxel...

Is there a particular sequence you would adjust contributing antirejection or antimicrobial medications? Is the use of G-CSF appropriate and at what c...

Hydroxyurea is demonstrated to reduce complications and improve long-term outcomes in severe genotypes HbSS and sickle beta0 thalassemia. What clinica...

What if the patient is triple-positive or has continued seropositivity on repeat lab testing? What is the appropriate interval of monitoring and does ...

Provoked or unprovoked VTE: Do you use D-Dimer (or even repeat imaging to reassess residual clot) in any capacity to guide anticoagulation duration? E...

Have you used anticoagulants other than coumadin? Or is that the only appropriate agent given monitoring is based on PT/INR?

While building a trusting patient-physician relationship, what therapies could be discussed that may be aligned with naturopathic medicine? (i.e. L-gl...

Does manipulation of blood products (leukoreduction, irradiated) affect your approach? There is growing evidence that routine premedication (at least ...

While this is a known risk factor for venous [Meijers et al NEJM 2000] and potentially arterial [Yang et al, Am J Clin Pathol 2006] thrombosis, it is ...

Are there major differences in standard conditioning and/or GVHD prophylaxis regimens utilized? Does the non-relapse mortality different significantl...

How often do you monitor ADAMTS-13 levels off therapy?

For example, do we prefer one regimen over the other in patients with a bleeding history or who have relapsed after a lengthy remission?

While benefits outweigh known harms and limited data, do you worry about vaccination in patients with a history of or active autoimmune cytopenias (e....

While thrombophilia testing is not routinely recommended prior to starting OCPs, how about after the development of a VTE?

Especially in a triple-positive patient with an acute ischemic stroke who may have urgency for anticoagulation with high bleeding risk and severe thro...

The patient who has not responded to steroids, rituximab/bendamustine, and splenectomy?

Would you give a trial of IST first or immediately refer for SCT if the patient has matched siblings?

Has your medical practice taken any steps either in community outreach or within the clinic to show support for this medically vulnerable population, ...

During the Stimate recall, how are we performing DDAVP challenges for newly diagnosed hemophilia A or von Willebrand disease?

Given the high cost of eculizumab, are there patient characteristics that inform which patients, if any, should be on indefinite therapy versus a time...

For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?

If autoimmune neutropenia already suspected, is this test informative or unnecessary?

What is the lowest level you have seen with uncomplicated or complicated crises?

There are various formulations of intravenous iron; each with varying costs, test dose requirement, elemental dose, and number or time of infusions ne...

Is there a preferred strategy of transfusional support versus reduced-dose anticoagulation during the duration of thrombocytopenia?


Papers discussed in this category


Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2016-04

Blood, 2018 Jul 12

Ann. Intern. Med., 2019 Oct 15

Blood Transfus, 2018 Oct 24

J Thromb Haemost, 2018 May 08

The New England journal of medicine, 2017-02-02

Blood, 2009 Nov 10

American journal of hematology, 2011-10

The American journal of medicine, 2017-12

American journal of hematology, 2018-05

Am J Hematol, 2020 Jun 29

Am J Hematol, 2019 Sep

Am J Hematol, 2018 Jun

JAMA,

N Engl J Med,

BMJ, 2008 May 20

Circulation,

Journal of thrombosis and haemostasis : JTH, 2018-06-07

Blood, 2010-07-22

Am J Gastroenterol,

American journal of hematology, 2008-08

Blood, 2017-07-20

Clin J Am Soc Nephrol, 2016 Oct 31

Blood, 2020 Dec 03

Rheumatol Int, 2019 Apr 30

Clin Exp Rheumatol, 2012 Sep 25

Wien Klin Wochenschr,

J Rheumatol, 2006 Jul 01

Semin Arthritis Rheum,

Am J Prev Med,

J Natl Med Assoc,

J Adv Nurs, 2015 Sep 09

Issues Ment Health Nurs, 2018 Apr 13

JAMA Netw Open, 2020 May 01

Emerg Infect Dis, 2020 Jul 08

Blood, 2013-12-05

Blood Adv,

Blood,

Blood, 2013 Sep 19

The Lancet. Haematology, 2015-09

Haematologica, 2017-07

Blood, 2018 Jun 13

Blood, 2010 Jul 15

Transfus Med Rev,

Seminars in hematology, 2013-07

Ann Oncol, 2021 Mar 18

Semin Hematol,

Blood, 2016-07-14

Blood, 2016 Sep 26

Transfusion, 2020 Sep 24

Lancet Haematol,

Transfusion, 2017 May 03

Autoimmun Rev, 2017 Sep 09

Br J Haematol, 2013 Aug 02

Blood Adv, 2020 Jan 28

Blood, 2019 Apr 25

J Clin Med, 2020 Nov 23

Am J Hematol, 2012 May 28

Lupus, 2021 May 27

Journal of the National Medical Association, 2009-10

Blood,

Lancet,

Am J Hematol, 2019 Aug 07

Clin Microbiol Infect, 2018 Feb 07

Blood, 2013-08-01

Circulation, 2003 Jun 17

Haematologica, 2007 Feb

PLoS One, 2015 Dec 30

Int J Lab Hematol, 2021 Oct 05