Medical Oncology

Colorectal Cancer   

Questions discussed in this category



How would the sidedness of the tumor, BRAF, RAS,HER2 or MSI status affect your decision?

Would you use a small cell regimen over a more traditional FOLFOX-esque approach?

Would you use dual agent chemotherapy such as FOLFIRI, combination of chemo with biologic- IRI/Cetux or all 3 drugs simultaneously? How would sidednes...

Given that majority of benefit is derived from the capecitabine, would this be an acceptable option to decrease patient contact with the healthcare sy...

Would presence of features considered high risk in stage II sway your interpretation of the IDEA trial? 

Do you use the same high risk factors as adenocarcinoma when deciding on adjuvant treatment for early stage disease?

In practice, does starting with chemoradiation followed by chemotherapy result in a significant delay in initiating chemotherapy or a patient's abilit...

The German trial included patients with tumors up to 16cm from the anal verge, while the Swedish trial update found no local control benefit for tumor...

Would you approach with curative intent with locoregional treatment or systemic treatment alone?

The NCCN seems to make its recommendation based on extrapolation from colon cancer, but those patients are not treated with pre-op chemoRT.

Has the utility of BRAF in CRC expanded beyond guiding prognosis? Is there a role in non-metastatic CRC?

If a patient with stage II or III colon adenocarcinoma who presents to your clinic 12-16 weeks after surgical resection do you give adjuvant chemother...

Is there a change in approach over the past few years? Would there be a role for the 12-gene recurrence score?

Since some prior subset analyses have suggested that oxaliplatin may not improve outcomes of older patients with colon cancer in the adjuvant settin...

Does the recent Hopkins trial of pembrolizumab change your management of these patients?


Papers discussed in this category


J. Clin. Oncol.,

Lancet Gastroenterol Hepatol, 2019 Jul 29

Diseases of the colon and rectum, 2008-08

JAMA oncology, 2018-06-14

J. Clin. Oncol., 2019 Oct 08

The New England journal of medicine, 1985-06-06

Cancer,

Eur J Surg Oncol,

Ann. Surg. Oncol., 2010 Sep 21

Clin Epidemiol, 2012 Nov 07

HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016-03

Lancet Oncol., 2016-06-01

Nature, 2018-02-08

The Lancet. Oncology, 2019-04

Neuroendocrinology, 2019 Aug 21

Ann. Surg., 2019 Aug 30

Expert Opin Biol Ther, 2019 Mar 27

J. Clin. Oncol., 2019 Oct 14

Lancet Oncol., 2015 Aug 31

Lancet Oncol., 2020 Mar 09

J. Clin. Oncol., 2003 Sep 08

N. Engl. J. Med.,

N Engl J Med, 2015 Jun 25

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-03-10

N. Engl. J. Med., 2019 Sep 30

J. Clin. Oncol., 2019 May 31

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-11-01

N. Engl. J. Med.,

Br. J. Cancer,

Int. J. Cancer, 2017 Jun 08

British journal of cancer, 2011-02-01

Anticancer Res.,

Annals of surgical oncology, 2018-08

Biosci. Rep.,

J Natl Compr Canc Netw,

J Natl Compr Canc Netw,

Anticancer Res.,

N. Engl. J. Med., 2019 Jun 02

Journal of the National Cancer Institute, 2018-11-01

J. Clin. Oncol., 2020 Jan 24

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-07-10

Science translational medicine, 2016-07-06

JAMA oncology, 2019-05-09

J. Clin. Oncol., 2012 Aug 20