Radiation Oncology

Pediatric Oncology   

Questions discussed in this category



Some emerging data of improved up front therapy shifting recurrence to CNS as sanctuary site, is focal RT approach (i.e. SRS) reasonable or is CSI a s...

Would you manage this histology any differently relative to other low grade gliomas? Is a STR a definite indication for postoperative XRT?

Assuming it has previously been treated with excision and steroid injections? Is it reasonable to treat a bothersome keloid in a pediatric patient aft...

With the recent publication of multi-institutional trial data, should this now become standard of care?

Would the translocation status influence your decision? Are there specific subsites where elective radiotherapy likely offers a higher therapeutic rat...

Would you consider radical cystectomy equivelant in terms of local control and how do you balance morbidity of radiation with morbidity of non-organ p...

In a patient with high risk rhabdomyosarcoma with significant marrow involvement (Stage IV), who has responded completely on imaging to all known site...

Would you treat this with whole-abdomen RT with a boost? What dose would you recommend? This would be Stage 1, Group 2 (R1 resection), low risk; but l...

Does the St. Jude's Experience (NEJM 2009, PMID: 19553647) provide sufficient justification for routine omission in high risk patients?

Is it recommended in every pediatric patient?  Are there any guidelines for organ-specific surveillance after XRT for children based on age, dose...

For example, if there was a common iliac node, does external iliac nodal region also need to be included? When, if ever, do you include the exter...

Assuming CSF is negative for neoplastic cells would you: Re-irradiate gross disease only? Re-irradiate posterior fossa only? Re-irradiate the entir...

Is there any role for consolidative RT/CRT to the lung and mediastinum after initial chemo? What dose and fractionation would be most appropriate for ...

We often see young women with favorable, early stage disease in the mediastinum who have had a complete response to chemotherapy. With current smaller...

 If so in what circumstances and what margin is acceptable? ACNS 0331 recently showed no difference in outcomes when comparing IFRTboost vs ...

How would you approach a patient with significant extension or metastasis in to the spinal canal?

After ABVE-PC X4 and Ifos/vinorelbine x 2 per AHOD 0831 (and is unable to have these sites biopsied), what dose would you treat to and what volume wou...

AREN0533 schema requires knowledge of 1p16q status, though this test is not available off-protocol. How does this affect management for patients treat...

The more recent NWTS trials do not include these tumors, since rhabdoid are recognized to not be similar to Wilms, and the AREN0321 does not provide s...

It seems that with the arms up, you get better lung blocking but with arms akimbo, you might have a lower dose to the humeral head. 

Scanning beam only machines are being increasingly marketed, it could be problematic if you can't use them to treat the one site which is most appropr...


Papers discussed in this category


Pediatr Blood Cancer, 2010 Jan

Pediatr Blood Cancer, 2008-09-01

Pediatr Blood Cancer, 2010-01-01

J Clin Oncol, 2014 Nov 10

Br J Radiol,

Burns, 2014 Apr 24

Pediatrics, 2012 Dec 17

Pediatrics, 2016 Jan 07

Pract Radiat Oncol, 2015 Mar-Apr

Cancer, 2004 Aug 15

Br. J. Haematol., 2003-11-01

Br. J. Haematol., 1998-08-01

Cancer, 1990-11-15

Radiother Oncol, 1990-01-01

J Clin Oncol, 2004 Aug 1

Nature, 2014 Feb 27

J Clin Oncol, 2016 Jul 20

Cancer Cell, 2015-05-11

Neuro-oncology, 2016-07-01

J. Radiat. Res., 2017-05-01

J. Neurooncol., 2003-01-01

Int J Radiat Oncol Biol Phys, 2008 Mar 1

Lancet Oncol, 2006 Oct

Int J Radiat Oncol Biol Phys, 2010 Aug 1

J. Clin. Oncol., 1999-03-01

Int. J. Radiat. Oncol. Biol. Phys., 2017-01-01

J Neurooncol, 2012 Jan

Am J Clin Oncol, 2012 Feb

Eur. J. Cancer, 2017-03-01

Int J Radiat Oncol Biol Phys, 2012 Oct 1

J Neurooncol, 2014 May

Int J Radiat Oncol Biol Phys, 2000 May 1

J Neurooncol, 2015 May

J Neurosurg Pediatr, 2016 Apr

Pediatr Blood Cancer, 2016-03-01

Int. J. Radiat. Oncol. Biol. Phys., 2018-02-01

J. Pediatr. Hematol. Oncol., 1999 Sep-Oct

Int. J. Radiat. Oncol. Biol. Phys., 2017-12-01

Lancet Oncol., 2017-08-01

Pediatrics, 2010-04-01

J. Clin. Oncol., 2016 Jan 11

Pediatr Blood Cancer, 2011 Apr 07

Cancer,

Med. Pediatr. Oncol.,

Arch. Dis. Child.,

Pediatr Blood Cancer, 2017 Dec 29

Br. J. Haematol.,

Int J Radiat Oncol Biol Phys, 2012 Nov 30

Int J Radiat Oncol Biol Phys, 2008 Jun 1

Pract Radiat Oncol, 2015 Nov 11

Int J Radiat Oncol Biol Phys, 2004 Jul 15

Int J Radiat Oncol Biol Phys, 2013 Nov 1

Ann. Oncol.,

J Clin Oncol, 2003 Apr 15

Cancer, 2011 Jun 15

J. Clin. Oncol.,

Lancet Oncol.,

J Clin Oncol, 2007 Feb 20

Acta Neuropathol., 2011 Jan 29

J. Neurol. Sci., 2006 Dec 26

J. Clin. Oncol., 2017 Jul 20

Int J Radiat Oncol Biol Phys, 2010 Nov 1

Pediatr Hematol Oncol,

Cancer,

Lancet Oncol., 2017 May 23