Gynecologic Cancers

Medical Oncology   

Questions discussed in this category


Given recent approval of niraparib (Zejula) for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or prima...

There are mixed recommendations about re-testing vs simply waiting for a quarantine period prior to resuming therapy. 

The patient has a history of pelvic radiation and progressed through first line carboplatin/taxol. She has had a partial response to pembro/lenvatinib...

After optimizing symptoms and reversible factors, and attempting cognitive-behavioral interventions and exercise, do you recommend pharmacologic agent...

This case involves an impressive ‘high volume’ vaginal recurrence and patient was not originally planned for adjuvant therapy. Concerned t...

Since no data exists or is pending, and the two disease processes are similar, should we consider PARP inhibition in this setting? This is assumi...

I am considering every 6 week pembrolizumab dosing in patients >70 years old in whom I want to reduce clinic visits for, especially in the context ...

This has been a common practice in the community. Is there a benefit for certain patients?

How would you approach a patient who is receiving chemoRT but has confirmed COVID-19 with minor symptoms, as breaking treatment for 2 weeks quarantine...

When a physical exam is important and telehealth is not a good option, should we be proactive and reschedule or should we continue to see them as sche...

Would you be more or less likely to use a cisplatin-containing regimen if a patient had previously responded to chemoradiation with concurrent cisplat...

Should this be done at the time of recurrence or after failure of 1st line therapy for recurrence?

The NCCN recommends either systemic therapy + brachytherapy or pelvic RT + brachy or brachy alone or observation. How do you decide among these option...

Given the recent press release regarding the update on the phase 3 soft tissue sarcoma study of LARTRUVO (olaratumab) showing no benefit to the combin...

Two new phase 2 studies this year with apatinib/oral etoposide (AEROC) and sorafenib/topotecan (TRIAS) were released, and NCCN also lists many single ...

Certainly ovarian cancer will respond to carboplatin and paclitaxel and it sounds like a reasonable chemotherapy to give to a stage IV NSCLC, however ...

In a patient who underwent laparoscopy for endometriosis and was found to have a 1mm focus of neuroendocrine tumor, would you recommend further surger...

Would you approach this situation as synchronous primaries (eg. FIGO IA in both) or as a locally advanced endometrial cancer (FIGO IIIA)? What adjuva...

Would you add chemotherapy if there was gross residual disease, pN+ and/or ECE?

Can the classic indications for post-hysterectomy radiation (eg. "Sedlis" and "Peter's" criteria) be applied? Does the histology change radiation dose...

How many cycles do you prefer before and after? How long do you tend to wait before starting radiation after initial chemo and after radiation to resu...

Do you try to keep Hb> 10 or 12? Or somewhere in between? 


Papers discussed in this category


Gynecologic oncology, 2010-03

The New England journal of medicine, 2019-06-13

Lancet Oncol., 2019 Jul 22

Gynecol Oncol, 2019 Sep

Gynecologic oncology, 2004-04

American journal of obstetrics and gynecology, 2010-10

Obstetrics and gynecology, 1988-01

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2014-11

Gynecologic oncology, 2015-06

The Lancet. Oncology, 2017-09

Cancer, 1987-10-15

Gynecologic oncology, 2015-09

Curr Oncol Rep,

Adv Anat Pathol,

Gynecologic oncology, 2014-11

N Engl J Med, 2016 Feb 25

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-01

The New England journal of medicine, 2011-12-29

N Engl J Med, 2011 Dec 29

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-09-10

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-06-10

Lancet Oncol, 2017 Jun

Lancet (London, England), 2017-10-28

The New England journal of medicine, 2016-12-01

The New England journal of medicine, 2012-04-12

J. Clin. Oncol.,

J Clin Oncol, 2014 May 1

Int J Gynecol Cancer, 2018 Mar

Br. J. Cancer,

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2015-02

The New England journal of medicine, 2018-12-27

Gynecologic oncology, 2018-10

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-07-10

International journal of radiation oncology, biology, physics, 1994-06-15

International journal of radiation oncology, biology, physics, 2010-12-01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010-06

Clinical cancer research : an official journal of the American Association for Cancer Research, 2015-12-15

N. Engl. J. Med., 2019 Sep 28

Science (New York, N.Y.), 2017-07-28

The New England journal of medicine, 2018-05-31

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-12-20

Lancet Oncol, 2013 Sep

J. Clin. Oncol., 2019 Apr 19

Br. J. Cancer, 2009 Feb 17

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2011-05

Lancet Oncol., 2020 Feb 14

Ann. Oncol., 2020 Mar 26

Current treatment options in oncology, 2018-11-15

Gynecol. Oncol., 2019 Oct 17

J Oncol Pharm Pract, 2020 Jan 06

Lancet, 2019 Nov 29

Lancet Oncol., 2014 Feb 28

Lancet,

N Engl J Med, 2019 Dec 19

Gynecologic oncology, 2009-08

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01

Lancet Oncol.,

Br. J. Cancer, 2018 Oct 24

J. Clin. Oncol., 2011 Mar 28

BMC Cancer, 2017 Apr 28

Nature, 2013-05-02

Gynecologic oncology, 2019-09

F1000Res, 2019 Jun 12

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-09-01

Journal of the National Cancer Institute, 2013-08-21

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010-02

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-07-20

Lancet Oncol., 2018 Feb 12

Blood, 2008-05-15

The New England journal of medicine, 2019-02-21

J Thromb Haemost, 2019 Jul 28

N Engl J Med, 2018 Dec 04

Obstet Gynecol,

JAMA,

Cancer Prev Res (Phila), 2019 Aug 16